DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and Man2a2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_008757749.1	Gene:	Man2a2 / 308757	RGDID:	1310238	Length:	1175	Species:	Rattus norvegicus

Alignment Length:	1103	Identity:	274/1103 - (24%)
Similarity:	450/1103 - (40%)	Gaps:	254/1103 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 INIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKW 101
            :.:.:|||||:|.||:||.|:||...        .|:|:::::|:|.::|.|||:..|.|||:||
  Rat   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   102 WNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVG 166
            |:..|...||.|:.||..|:|:...|.|.|.|||..:|.:::||...|.::|:...|  ..||.|
  Rat   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   167 WQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDAS-ESLSQVKLFTGLLY 230
            |.:||||||.....:..:.........|:.:..|.......:||.:|..: :|.|...:|..::.
  Rat   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP 350

  Fly   231 TFYWDTPGFC---------FD--------VHC--------------SDDPIIDSDSYDNNVKSRV 264
            .:.:|.|..|         ||        ::|              :|...:..|.|  ..|||:
  Rat   351 FYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQY--RKKSRL 413

  Fly   265 DDFIAYAAQVAEKFRTNHIMIPMGGDFQY---EDAEVNYKNMDKLIKYVNERQSSGSKYNI--IY 324
                         ||::.:::|:|.||:|   ::.:..:.|..:|..::|    |..::::  .:
  Rat   414 -------------FRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN----SKPEFHVQAQF 461

  Fly   325 STPTCYLNSVHKSV--------QSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQ 381
            .|.:.|.::::|..        ..:|..:.|||.|....:.:|||||||||..|..:|.....|:
  Rat   462 GTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLETHLR 526

  Fly   382 VAKQLSAFA-------ELSSTQQKEDLEYL---REIMGVMQHHDAITGTEKQHVSDDYDRILYDA 436
            .|:.|.:.|       .|:......|...|   |..:|:.|||||||||.|:.|..||
  Rat   527 GAEVLYSLALAHARRSGLTGQYPLSDYAVLTEARRTLGLFQHHDAITGTAKEAVVVDY------- 584

  Fly   437 IVGGVKTAGDALRKLTNL----------------------PNGEFESCLQLNISECAFTK----- 474
               ||:    .||.|.:|                      |...|.......:|..|..:
  Rat   585 ---GVR----LLRSLVSLKQVIINAAHYLVLGDKETYSFDPRAPFLQMDDSRVSHDALPERTVIR 642

  Fly   475 -DGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEI----------------VPV 522
             |.:...|| ::|.|.......|.:.|.:...:|..|:|:.::.:|                |.|
  Rat   643 LDSSPRFVV-VFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVQWSSATNMVPDVYQVSV 706

  Fly   523 PAEVLALEFRDSDTQHELVFKASVDKIANYYIKKVD---SKESSNGVRVISQPKANAETYDDEET 584
            |..:.||.......|.:|....::....:.|:..|.   |::::..:||:..        ...:.
  Rat   707 PVRLPALGLGVLQLQPDLDGPYTLQSSVHVYLNGVKLSVSRQTTFPLRVVDS--------GTSDF 763

  Fly   585 IVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQS-------YGLYRTYD-SGAYVFRQYNQGDFVI 641
            .:....:::.....|||||.|..  |.|..||.       ||...:.| ||||:|...|:....:
  Rat   764 AISNRYMQVWFSGLTGLLKSVRR--VDEEQEQQVDMKLFVYGTRTSKDKSGAYLFLPDNEAKPYV 826

  Fly   642 QEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVE-------FEWLVGPIPVEEEFGTEV 699
            .:......|.:|....|| ..:.|:..||||: .:.|.||       |:     :.:.:....|:
  Rat   827 PKKPPVLRVTEGPFFSEV-AAYYEHFHQVIRL-YNLPGVEGLSLDVSFQ-----VDIRDYVNKEL 884

  Fly   700 VTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAI 764
            .....::|.|.|.|:||.||.::..|:..|:         .|...|:||:.....:|||.:||.:
  Rat   885 ALRIHTDIDSQGTFFTDLNGFQVQPRKYLKK---------LPLQANFYPMPVMAYIQDSQRRLTL 940

  Fly   765 LNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEK---------------------YGQP 808
            ...:|.|.:|:.:||:|::|.|||::||..|:|:.|.:.|                     :...
  Rat   941 HTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKDNKITCNHFRLLLERRTLMSPEPGFFSK 1005

  Fly   809 LIA--RGKVFLILNAADESTSAEREAEKEFHL-----------PLWKFFSKNTGSTTAAAKSVPS 860
            |.|  ||.:|......:.....||.......|           ||....:|...::.......|.
  Rat  1006 LAAMFRGLIFSSNTIRNSKVQQERSTSYPSLLSHMTSMYLNTPPLVLPVAKRESTSPTLHSFHPL 1070

  Fly   861 FDDFPKSVHLLTLE--------PFNDDEILLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETT 917
            ....|...|||.|.        |..|..::|..:.|...:|.|.:.||.              ||
  Rat  1071 ASPLPCDFHLLNLRMLPAEDTLPAADAALILHRKGFDCGLEAKNLGFNC--------------TT 1121

  Fly   918 LDGNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIK 980
            ..|.|.|..:    ||  |..:...:|...|..:...|.:.:.|     ::|.||:|.||.::
  Rat  1122 SQGKLALGSL----FH--GLDVLFLQPTSLTLLYPLASPSNSTD-----ISLEPMEISTFRLR 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	87/308 (28%)
		Alpha-mann_mid	358..433	CDD:286360	33/84 (39%)
		Glyco_hydro_38C	481..977	CDD:285047	131/571 (23%)
Man2a2	XP_008757749.1	PLN02701	140..1174	CDD:178304	274/1103 (25%)
		CE4_SF	165..508	CDD:301698	100/370 (27%)
		Alpha-mann_mid	503..588	CDD:214875	35/98 (36%)
		Glyco_hydro_38C	761..1170	CDD:285047	109/451 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810