DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and Man2a1

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_037111.2	Gene:	Man2a1 / 25478	RGDID:	3038	Length:	1148	Species:	Rattus norvegicus

Alignment Length:	1085	Identity:	268/1085 - (24%)
Similarity:	457/1085 - (42%)	Gaps:	223/1085 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRF 90
            ||: .|.....:.:.:|||||:|.|||||.:.|:   |:.     .|||.:.::.:|.::..|:|
  Rat   155 YEA-DEWDREPLQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKF 210

  Fly    91 IQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDD 155
            |..|.|:.:|||:......:..||.|:..|:|:.:.|.|.|.|||..:|.::|||...|.::|:.
  Rat   211 IWSEISYLAKWWDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEK 275

  Fly   156 TFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESL- 219
            ..||  :||.||.|||||||.....:..:.||......|:.::.|........||..|..:..|
  Rat   276 NLGV--KPRSGWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLG 338

  Fly   220 SQVKLFTGLLYTFYWDTPGFCFDVH-CSDDPIIDSDSYD----------------------NNVK 261
            |...:...::..:.:|.|      | |..||.| ...:|                      .||:
  Rat   339 STTDILCHMMPFYSYDIP------HTCGPDPKI-CCQFDFKRLPGGRYGCPWGVPPEAISPGNVQ 396

  Fly   262 SRVDDFIAYAAQVAEKFRTNHIMIPMGGDF---QYEDAEVNYKNMDKLIKYVNERQSSGSKYNII 323
            ||....:....:.::.|||..::.|:|.||   :|.:.::.|:|.::|..|:|.:..  .|..|.
  Rat   397 SRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPH--LKVKIQ 459

  Fly   324 YSTPTCYLNSVHKSVQS--------YPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHIL 380
            :.|.:.|.:::.|||.:        :|..:.|||.|....:.:|:||:||||..||.:|.....|
  Rat   460 FGTLSDYFDALEKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRL 524

  Fly   381 QVAKQLSAFAELSSTQQKEDLEYL-----------REIMGVMQHHDAITGTEKQHVSDDYDRILY 434
            :.|:.|...| |...|:.:..::|           |..:|:.|||||||||.|..|..||...|:
  Rat   525 RTAEILYHLA-LKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLF 588

  Fly   435 DAIVGGVKTAGDAL-------RKL-------------------TNLPNGEFESCLQLNISECAFT 473
            .::....|..||:.       :||                   .:||.   ::.:||:..|..:
  Rat   589 QSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPK---KNIIQLSAQEPRY- 649

  Fly   474 KDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPAEVLALEFRD----S 534
                    :.:||.........|.|.|.:...:|..:.|:.|..::..|        ::|    |
  Rat   650 --------LVVYNPFEQERHSVVSVRVNSATVKVLSDLGKAVEVQVSAV--------WKDMRTTS 698

  Fly   535 DTQHELVFKASVDKIANYYIKKVDSKESSNGVR--VISQPKANAET--------YDDEETI-VQT 588
            ...:|:.|.|.:..:.....|.::|:.||:.:.  .:......||:        .|..:.| ::.
  Rat   699 QAAYEVAFLAHLPPLGLKVYKILESQSSSSHLADYFLYNNDGQAESGIFHMKNMVDSGDAITIEN 763

  Fly   589 SLIKLVLDNKTGLLKRVEMNGVSENIEQS-------YGLYRTYD-SGAYVFRQYNQGDFVIQEDG 645
            |.:.|..| ::||:::|...  .:|.:|.       ||.....| ||||:|....||...:....
  Rat   764 SFLTLGFD-RSGLMEKVRRK--EDNKQQELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSLRT 825

  Fly   646 VEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGP-------IPVEEEFGTEVVTIF 703
            ....|..|.:..:| ..|.|:::..:|:      ...:.:.|.       :.:......|:|...
  Rat   826 PFVRVTRGRIYSDV-TCFLEHVTHKVRL------YHIQGIEGQSMEVSNIVDIRSVHNREIVMRI 883

  Fly   704 SSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILNDR 768
            ||:|.:...:|||.||.::..|.         .:|..|...|.||:::...:||:..||.:|:.:
  Rat   884 SSKINNQNRYYTDLNGYQIQPRR---------TMAKLPLQANVYPMSTMAYIQDAAHRLTLLSAQ 939

  Fly   769 AQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKYGQPLIARGKVFLILNAADESTSAEREAE 833
            :.|.:||..||||:.:.|||::||..|:|:.:::.|      ....:|.||.......:.|.:.:
  Rat   940 SLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNK------ITANLFRILLEKRNGMNMEEDKK 998

  Fly   834 KEFHLP-----LWKFFSKNTGSTTAAAKSVPS-----FDDF-------PKSVHLLTL-------- 873
            .....|     :...|..:.......:..:||     ..:|       |..:||:.|
  Rat   999 SPVSYPSLLSHMTSAFLNHPFLPMVLSGQLPSPAIELLSEFRLLQSSLPCDIHLVNLRTIQSKVG 1063

  Fly   874 EPFNDDEILLRVENFKDHIEGKVVSFNIRPIFD---YLNGVEIRETTLDGNLPLSDMKQFKFHAE 935
            :.::|:..|:.      |          |.:||   ....:.:..:|..|.:.:.  |.|...|.
  Rat  1064 KGYSDEAALIL------H----------RKVFDCQLSSRAMGLPCSTTQGKMSIP--KLFNNFAV 1110

  Fly   936 GSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIK 980
            .|.|    |...:..|.|..|..|.:     |:|.||:|.|..|:
  Rat  1111 ESFI----PSSLSLMHSPPDAQNTSE-----VSLSPMEISTSRIR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	88/300 (29%)
		Alpha-mann_mid	358..433	CDD:286360	32/85 (38%)
		Glyco_hydro_38C	481..977	CDD:285047	119/553 (22%)
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	268/1085 (25%)
		GH38N_Man2A1	164..507	CDD:212131	103/361 (29%)
		Alpha-mann_mid	502..587	CDD:214875	32/85 (38%)
		Glyco_hydro_38C	733..1142	CDD:285047	101/460 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1148		11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810