DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and MAN2B2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_056089.1	Gene:	MAN2B2 / 23324	HGNCID:	29623	Length:	1009	Species:	Homo sapiens

Alignment Length:	1071	Identity:	276/1071 - (25%)
Similarity:	447/1071 - (41%)	Gaps:	221/1071 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 INIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKW 101
            |...:|||||.||||:.||.:....:..|        :..:|:.||.:...||||.||..||..|
Human    27 IRAFVVPHSHMDVGWVYTVQESMRAYAAN--------VYTSVVEELARGQQRRFIAVEQEFFRLW 83

  Fly   102 WN-EQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRV 165
            |: ..|:..:..|:.|:.||||:|:.|...|:|||..:....|.|.|.|..||.:|||:  ||:.
Human    84 WDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQF 146

  Fly   166 GWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLSQ-VKLFTGLL 229
            .|.:||||.|....:::|..||:....||:|::.|........|:.:|..|.|||: .::||.::
Human   147 SWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEIFTHIM 211

  Fly   230 YTFYWDTP---------GFCFD-VHCSDDPIIDSDSYDN--------NVKSRVDDFIAYAAQVAE 276
            ..:.:.||         ||.:: |.....|..|. .|.|        |:....:..:|...|.|.
Human   212 DQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPQDG-VYPNMSEPVTPANINLYAEALVANVKQRAA 275

  Fly   277 KFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLNSVHK-SVQS 340
            .|||.|::.|.|.|.|:.:|.|.:.|||.|:.::|. .::....::.|:|...|..::|. :|..
Human   276 WFRTPHVLWPWGCDKQFFNASVQFANMDPLLDHINS-HAAELGVSVQYATLGDYFRALHALNVTW 339

  Fly   341 YPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQL-------SAFAELSSTQQK 398
            ......||.||.::....|||:||||.:.|...|..:.:|...:.:       :....|..|...
Human   340 RVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALLYAGESMFTRYLWPAPRGHLDPTWAL 404

  Fly   399 EDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDALRKL-TNLPNGEFESC 462
            :.|:.||..:..:||||||||||...|.|.|...|...::|        :||| .::...|
Human   405 QQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHLASGMLG--------MRKLMASIVLDE---- 457

  Fly   463 LQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPAEVL 527
            ||......|.:..|......::||.||.|....|.:.|.....:||||.|.       |||:::
Human   458 LQPQAPMAASSDAGPAGHFASVYNPLAWTVTTIVTLTVGFPGVRVTDEAGH-------PVPSQI- 514

  Fly   528 ALEFRDSDTQHELVFKASVDKIA--NYYIKKVDSKESSNGVRVISQPKANAETYDDEETIVQTSL 590
             ....::.:.::|:...::..::  :|.|:                |.|.|:....|......|.
Human   515 -QNSTETPSAYDLLILTTIPGLSYRHYNIR----------------PTAGAQEGTQEPAATVAST 562

  Fly   591 IK-------------------------LVLDNKTGLLKRV--EMNGVSENIEQSYGLYRTYD--- 625
            ::                         ::||..|.|:..:  ..:..:..:.|.:..|....
Human   563 LQFGRRLRRRTSHAGRYLVPVANDCYIVLLDQDTNLMHSIWERQSNRTVRVTQEFLEYHVNGDVK 627

  Fly   626 ----SGAYVFRQYNQGDFVIQE-DGVEFTVYDGALVKEVHQRFSEYI----------SQVIRISE 675
                |..|:|   ..|...:.. :.||..:..|.||.|:.|.|...:          |::..:.:
Human   628 QGPISDNYLF---TPGKAAVPAWEAVEMEIVAGQLVTEIRQYFYRNMTAQNYTYAIRSRLTHVPQ 689

  Fly   676 DKP------YVEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFT 734
            ...      .:|.|:..||:    |...|.|...|:.:.|..|.|:|:||.::.||
Human   690 GHDGELLCHRIEQEYQAGPL----ELNREAVLRTSTNLNSQQVIYSDNNGYQMQRR--------- 741

  Fly   735 PELAVQPTS--GNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVR----DDG 793
            |.::....|  .||||:.....::|...||.:|::||.|.:|..:||:|:||||||..    |.|
Human   742 PYVSYVNNSIARNYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLG 806

  Fly   794 YGVGEALNEEKYGQPLIARGKVFLILNAADESTS-AEREAEKEFHLPLWKFFSKNTGSTTAAAKS 857
            |.:  .||:.....|::     :|:|.:...:|: .:|.|....|.|:..|     |.....|..
Human   807 YNL--TLNDTSVVHPVL-----WLLLGSWSLTTALRQRSALALQHRPVVLF-----GDLAGTAPK 859

  Fly   858 VPSFDDFPKSVHLLTLEP---------------FNDDE-------------------ILLRV--- 885
            :|.    |:....:||.|               .|..|                   :|||:
Human   860 LPG----PQQQEAVTLPPNLHLQILSIPGWRYSSNHTEHSQNLRKGHRGEAQADLRRVLLRLYHL 920

  Fly   886 -ENFKDHIEGKVVSFNIRPIFDYLNG-VEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEYYT 948
             |..:|.:..:.|:.|:..:...|.. |.:.|.:|.|...||.:.::.:.......||..    |
Human   921 YEVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWDLSMLHRWSWRTGPGRHRGDT----T 981

  Fly   949 SSHKPLSANQTQDAAEFAVTLYPMQIRTFII 979
            |..:|....        .:|::|.:||||.|
Human   982 SPSRPPGGP--------IITVHPKEIRTFFI 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	98/293 (33%)
		Alpha-mann_mid	358..433	CDD:286360	28/81 (35%)
		Glyco_hydro_38C	481..977	CDD:285047	127/594 (21%)
MAN2B2	NP_056089.1	GH38N_AMII_Epman_like	27..352	CDD:212122	108/336 (32%)
		Alpha-mann_mid	358..439	CDD:214875	28/80 (35%)
		Glyco_hydro_38C	581..1002	CDD:285047	104/464 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	972..991		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920