DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and aman-1

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_508811.1	Gene:	aman-1 / 180749	WormBaseID:	WBGene00018877	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	967	Identity:	345/967 - (35%)
Similarity:	510/967 - (52%)	Gaps:	73/967 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLALQAKSAQAVCGYESCHETKS--NMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYI 74
            ||.|....:...|.:.:||:...  |:|..||:||:|||:||:||||||::|.:..:...|||||
Worm     9 FLGLLVIYSSQDCAWNTCHKVDQDPNVITAHLIPHTHDDLGWIKTVDQYFWGAKPELVPVGVQYI 73

  Fly    75 IDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNY 139
            .:|||.||:|||||||...||.|..:|:...|:..|..::.||..|:::.|.|.|..||||..:|
Worm    74 YNTVIDELLKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHY 138

  Fly   140 QSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRM 204
            ..:|||.|:||:.|:..||.||:|..||||||||||||.|:||.:||:...:|:|:.:.:|..|:
Worm   139 VDIIDQMTLGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRL 203

  Fly   205 NDLALEMIWDASESLSQVKLFTGLLYTFYWDTP-GFCFDVHCSDDPIIDSDSYDN-NVKSRVDDF 267
            .:..||.:|:.|:.::..|||||..:...:..| |||:|..|.||||:|:.:.:. |||.:||.|
Worm   204 KNKTLEFMWNTSDDITDNKLFTGAFFNDNYGPPEGFCWDSLCGDDPIMDNLNIEGYNVKEKVDAF 268

  Fly   268 IAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLN 332
            :.:....|....||.:|:.||.||||.:|...|.|:||||||||  ..:..|..:|||||.||..
Worm   269 VDHVKNQAAHQSTNQVMLLMGSDFQYTNANSWYVNLDKLIKYVN--ADTSKKVRVIYSTPACYTK 331

  Fly   333 SVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFAELSSTQQ 397
            :|.....:...|..|||||.|..:|:||||:||||..|...|..:.:||:||||...|.| ..:.
Worm   332 AVQAKTPTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGMIRQASCMLQLAKQLDVIANL-GPED 395

  Fly   398 KEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDALRKLTNLPNG---EF 459
            ..|:|.|||...::|||||:|||.|::|:.||::.|...:........|.::|:.  |:|   :.
Worm   396 DSDIEILREASALVQHHDAVTGTAKENVTRDYEKQLAKGVSEVEVVINDFMKKMN--PDGLDPKL 458

  Fly   460 ESCLQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPA 524
            ..|..:|.:.|. ..:|:....|.::|:........:|:|...:...:.|....|:.|:||
Worm   459 VLCPLINETICK-PINGSSEFSVVIFNSNGRYFNGTIRIPYSQKTAVLRDAHKNVLESQIV---- 518

  Fly   525 EVLAL-EFRDSD-TQHELVFKASVDKIANYYIKKVDSKESSNGVRVISQPKANAETYDDEETIVQ 587
            |...: :.:|:| ..:|:.....|..: .|....|:.......|...::.|.|....      :|
Worm   519 ETFQIDQLKDTDRLPYEIHVFVRVPPL-GYTTVFVEKGSKPERVHFNNRKKFNTNVE------IQ 576

  Fly   588 TSLIKLVLDNKTGLLKRVEMNGVSE--NIEQSYGLYRTYD------SGAYVFRQYNQGDFVIQED 644
            ...:....|:: |.|..:......:  :|.|.:..|...|      ||||:||...|....:...
Worm   577 NEYLIAGFDSQ-GYLSYITEKATKKKRSIRQEFFYYEGIDSKDDQPSGAYIFRPKTQQPIALTSK 640

  Fly   645 GVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPVEEE--FGTEVVTIFSSEI 707
             :...|..||::.||.|:.|.::||.||:...|.|:||||:|||||.|.:  ...|.||.:::|:
Worm   641 -LALEVVPGAIINEVRQKVSPFVSQQIRLPRGKNYIEFEWIVGPIPKETKNPITKEFVTRYTTEV 704

  Fly   708 ASNGVFYTDSNGRELIRREKDKREDFTPELA-VQPTSGNYYPITSRIALQDSNKRLAILNDRAQG 771
            .|....:||||||:.:.|..|....|  |.: .:|.:||||||||...::|.|.:.:::.|||||
Worm   705 HSKNQSFTDSNGRQAMERFFDGATSF--EYSDTEPIAGNYYPITSFGYIKDENAQFSVITDRAQG 767

  Fly   772 GTSMKDGQIELMLHRRLVRDDGYGVGEALNEE-KYGQPLIARGKVFLILNAADESTSAERE-AEK 834
            ..: .||.:|:|||||...||.:||.|||:|. |.|..|:|.||..::......|||..|. |..
Worm   768 MVA-SDGVVEIMLHRRCFYDDHFGVEEALDEPGKDGAGLVAMGKHIVLFTDVKASTSQLRPLAID 831

  Fly   835 EFHLPLWKFFSKNTGSTTAAAKSVPSFD------------DFPKSVHLLTLEPFNDDEILLRVEN 887
            .||.|:..|           .|:...|:            :.|..:||||||.::....|:|.||
Worm   832 NFHQPVLAF-----------NKNPEKFEFNRLLEYSGLKFELPIGIHLLTLEKWHKKSSLIRFEN 885

  Fly   888 FKDHIEG-KVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSE 943
            .....|| .:..|:...||...:.|..:|..|..|..:...|:     .||..|..|
Worm   886 IYHGEEGNSIKEFDPTHIFTNFDIVSFKELLLGANRVVGKNKE-----SGSSFRSFE 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	129/275 (47%)
		Alpha-mann_mid	358..433	CDD:286360	35/74 (47%)
		Glyco_hydro_38C	481..977	CDD:285047	146/491 (30%)
aman-1	NP_508811.1	GH38N_AMII_LAM_like	36..313	CDD:212121	131/278 (47%)
		Alpha-mann_mid	357..431	CDD:286360	35/74 (47%)
		Glyco_hydro_38C	537..944	CDD:285047	133/429 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159881
Domainoid	1	1.000	326	1.000	Domainoid score	I640
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	644	1.000	Inparanoid score	I436
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm14669
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.760