Protein Alignment LManV and Man2b2

DIOPT Version :10

• Sequence 1: NP_609252.1
• Gene: LManV / 34205
• FlyBaseID: FBgn0032068
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_032576.2
• Gene: Man2b2 / 17160
• MGIID: 1195262
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1076
• Identity: 279/1076 - (25%)
• Similarity: 459/1076 - (42%)
• Gaps: 215/1076 - (19%)

  Fly    37 INIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKW 101
            |...:|||||.||||:.||.:....:..|        :..||::||::...||||.||..||..|
Mouse    27 IRAFVVPHSHMDVGWVFTVQESMRAYAAN--------VYTTVVAELVRGGQRRFIAVEQEFFRLW 83

  Fly   102 WN-EQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRV 165
            |: ..||..:..|:.|::||||:|:.|...|:|||..:....|.|.|.|..||.:|||:  ||:.
Mouse    84 WDGVASEQQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--RPQF 146

  Fly   166 GWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLS-QVKLFTGLL 229
            .|.:||||.|....:::|..||:....||:|::.|........|:.:|..|.||| |.::||.::
Mouse   147 SWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFTHVM 211

  Fly   230 YTFYWDTP---------GFCFD-VHCSDDPIIDSDSYDN--------NVKSRVDDFIAYAAQVAE 276
            ..:.:.||         ||.:: |....:|..|. .|.|        |:....:..:|...|.|.
Mouse   212 DHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDG-VYPNMSEPVTGANIHLYAEALVANVKQRAA 275

  Fly   277 KFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYSTPTCYLNSVHKSVQSY 341
            .|||.|::.|.|.|.|:.:|.|.:.|||.|:.|:|:|.:... .::.|:|...|..::|.:..::
Mouse   276 WFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFG-ISVQYATLNDYFQALHATNMTW 339

  Fly   342 PNKT-LDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQL-------SAFAELSSTQQK 398
            ..:. .||.||.|:....|||:||||.|.|...|..:.:|...:.:       .....|..|...
Mouse   340 GIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGESMFTRYMWPDPSGTLDPTWAL 404

  Fly   399 EDLEYLREIMGVMQHHDAITGTEKQHVSDDYD-----------RILYDAIVGGVKTAGDALRKLT 452
            :.|:.||..:..:||||||||||...|.:.|.           :::....:||...:|....|
Mouse   405 QQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKLMVSIALGGPPGSGTGAPK-- 467

  Fly   453 NLPNGEFESCLQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVAS 517
            ::...:....|.::.....::        .::||.||......:.:.|...|..||||.|..|::
Mouse   468 DIMGPQVTPVLSVDTRPVGYS--------ASVYNPLAWKITTIITLTVAFPNVSVTDELGHPVST 524

  Fly   518 EIVPVPAEVLALEFRDSDTQHELVFKASVDKIANYYIKKVDSKESSNGVRVISQPKANAETYD-- 580
            :|.....:..|         ::|:...::..:...:.:.:.::....|.|.:..|:||...:.
Mouse   525 QIQNSTKDPSA---------YDLLILTTIPGLNYRHYQVMHARGDQAGTRELVAPRANTLKFSLK 580

  Fly   581 -----DEE----TIVQTSLIKLVLDNKTGLLKRVE--MNGVSENIEQSYGLYR-TYD------SG 627
                 .:|    ..|......|:.|..|.:|..::  .:..:..:.|.:..|: .:|      |.
Mouse   581 LRNQPSQEGKRLVPVMNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLEYQANWDVKQGPISD 645

  Fly   628 AYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPY------------- 679
            .|:|...|..:...:..|:|...  |.||.::.|.|..||:       |:.|
Mouse   646 NYLFAPNNTAEPSWEAVGMEMVA--GTLVTDIRQYFYRYIT-------DQEYIYSIHTRLAHPSL 701

  Fly   680 --------VEFEWLVGPIPVEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPE 736
                    :|.::.|||:    :...|.:...||::.|..|.|:|:||.::.||         |.
Mouse   702 AGELLCQRIEQQYRVGPL----DLNREAILRTSSDLNSQQVLYSDNNGYQMQRR---------PY 753

  Fly   737 LAVQ--PTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRR----LVRDDGYG 795
            .|.:  |...||||:.....::|...||.:|.:|..|.:|..:||:|:|||||    |..|..|.
Mouse   754 KAFKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYN 818

  Fly   796 VGEALNEEKYGQPL---------------------IARGKVFLILNAADESTSAEREAEKEFHLP 839
            :  .||:.....|:                     :..|.|.|:...|||.|..        |.|
Mouse   819 L--TLNDTSIVHPVLWLMLGPKSTMTALHPRSGVALQHGPVVLLKELADEETPV--------HGP 873

  Fly   840 LWKFFSKNTGSTTAAAK------SVPSFDDFPKS--VHLLTLE-------PFNDDEILLRVENFK 889
                  .|....|....      |||.: .:.:|  .||..|:       ..|...:|||:.:..
Mouse   874 ------HNPWPVTLPPNLHLQILSVPGW-TYSRSHAQHLRNLQRGHPEKPQANLQRVLLRLRHLY 931

  Fly   890 DHIEGKVVSFNIRP----IFDYLNG----VEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEY 946
            :..|..|:|   ||    :...|.|    |.:.|.:|.|...:..::::.:..:...::|    :
Mouse   932 EAGEDPVLS---RPATVDLKVVLRGLGSVVAVEERSLTGTWDVQMLQRWHWSTKTDHLKG----H 989

  Fly   947 YTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIKHE 982
            .||..:|...:        .:|:||.:||||.||.:
Mouse   990 PTSPPRPPGGS--------IITVYPKEIRTFFIKFQ 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_609252.1	GH38N_AMII_LAM_like	37..311	CDD:212121	102/293 (35%)
		PLN02701	39..873	CDD:178304	249/948 (26%)
Man2b2	NP_032576.2	PLN02701	27..807	CDD:178304	226/832 (27%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	112/336 (33%)