Protein Alignment LManV and Man2a1

DIOPT Version :10

• Sequence 1: NP_609252.1
• Gene: LManV / 34205
• FlyBaseID: FBgn0032068
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_032575.2
• Gene: Man2a1 / 17158
• MGIID: 104669
• Length: 1150
• Species: Mus musculus
• Alignment Length: 1087
• Identity: 270/1087 - (24%)
• Similarity: 459/1087 - (42%)
• Gaps: 227/1087 - (20%)

  Fly    26 YESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRF 90
            ||: .|.....:.:.:|||||:|.|||||.:.|:   |:.     .|||.:.::.:|.::..|:|
Mouse   155 YEA-DEWDHEPLQVFVVPHSHNDPGWLKTFNDYF---RDK-----TQYIFNNMVLKLKEDSSRKF 210

  Fly    91 IQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDD 155
            :..|.|:.:|||:......:..||.|:..|:|:.:.|.|.|.|||..:|.::|||...|.::|:.
Mouse   211 MWSEISYLAKWWDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEK 275

  Fly   156 TFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESL- 219
            ..||  :||.||.|||||||...|.:..:.||......|:.:..|........||..|..:..|
Mouse   276 NLGV--KPRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLG 338

  Fly   220 SQVKLFTGLLYTFYWDTPGFCFDVH-CSDDPIIDSDSYD----------------------NNVK 261
            |...:...::..:.:|.|      | |..||.| ...:|                      .||:
Mouse   339 SATDILCHMMPFYSYDIP------HTCGPDPKI-CCQFDFKRLPGGRYGCPWGVPPEAISPGNVQ 396

  Fly   262 SRVDDFIAYAAQVAEKFRTNHIMIPMGGDF---QYEDAEVNYKNMDKLIKYVNERQSSGSKYNII 323
            ||....:....:.::.|||..::.|:|.||   :|.:.::..:|.::|..|:|.:..  .|..|.
Mouse   397 SRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQPH--LKVKIQ 459

  Fly   324 YSTPTCYLNSVHKSVQS--------YPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHIL 380
            :.|.:.|.:::.|:|.:        :|..:.|||.|....:.:|:||:||||..||.:|.....:
Mouse   460 FGTLSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRI 524

  Fly   381 QVAKQLSAFAELSSTQQKEDLEYL-----------REIMGVMQHHDAITGTEKQHVSDDYDRILY 434
            :.|:.|...| |...|:.:..::|           |..:|:.|||||||||.|..|..||...|:
Mouse   525 RAAEILYQLA-LKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLF 588

  Fly   435 DAIVGGVKTAGDAL-------RKL-------------------TNLPNGEFESCLQLNISECAFT 473
            .::....|..||:.       :||                   .:||.   :..:||:..|..:
Mouse   589 QSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPQ---KIIIQLSAQEPRY- 649

  Fly   474 KDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPAEVLAL--EFRD-SD 535
                    :.:||.........|.:.|.:...:|..:.|:       ||..:|.|:  :.|. |.
Mouse   650 --------LVVYNPFEQERHSVVSIRVNSATVKVLSDSGK-------PVEVQVSAVWNDMRTISQ 699

  Fly   536 TQHELVFKASVDKIANYYIKKVDSKESS----------------NGVRVISQPKANAETYDDEET 584
            ..:|:.|.|.:..:.....|.::|:.||                ||:..:.    |.....|..|
Mouse   700 AAYEVSFLAHIPPLGLKVFKILESQSSSSHLADYVLYNNDGLAENGIFHVK----NMVDAGDAIT 760

  Fly   585 IVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQS-----YGLYRTYD-SGAYVFRQYNQGDFVIQE 643
            | :...:.:..| ::||:::|.....|...|..     ||.....| ||||:|....||...:..
Mouse   761 I-ENPFLAIWFD-RSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSL 823

  Fly   644 DGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGP-------IPVEEEFGTEVVT 701
            ......|..|.:..:| ..|.|:::..:|:      ...:.:.|.       :.:......|:|.
Mouse   824 RPPFVRVTRGRIYSDV-TCFLEHVTHKVRL------YNIQGIEGQSMEVSNIVNIRNVHNREIVM 881

  Fly   702 IFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILN 766
            ..||:|.:...:|||.||.::..|.         .::..|...|.||:.:...:||:..||.:|:
Mouse   882 RISSKINNQNRYYTDLNGYQIQPRR---------TMSKLPLQANVYPMCTMAYIQDAEHRLTLLS 937

  Fly   767 DRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKYGQPLIARGKVFLILNAADESTSAERE 831
            .::.|.:||..||||:.:.|||::||..|:|:.:::.|      ....:|.||  .::.::...|
Mouse   938 AQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNK------ITANLFRIL--LEKRSAVNME 994

  Fly   832 AEKEFHLPLWKFFSKNTGS---------TTAAAKSVPSFD----------DFPKSVHLLTL---- 873
            .||:..:......|..|.|         ..:.....|:|:          ..|..:||:.|
Mouse   995 EEKKSPVSYPSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQSSLPCDIHLVNLRTIQ 1059

  Fly   874 ----EPFNDDEILLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQF-KFH 933
                :.::|:..|:.      |.:|....|:.|       |:.:..:|..|.  :|.:|.| ||
Mouse  1060 SKMGKGYSDEAALIL------HRKGFDCQFSSR-------GIGLPCSTTQGK--MSVLKLFNKF- 1108

  Fly   934 AEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIK 980
                .:....|...:..|.|..|   |:.:|  |:|.||:|.||.|:
Mouse  1109 ----AVESLVPSSLSLMHSPPDA---QNMSE--VSLSPMEISTFRIR 1146

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_609252.1	GH38N_AMII_LAM_like	37..311	CDD:212121	87/300 (29%)
		PLN02701	39..873	CDD:178304	238/956 (25%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	270/1087 (25%)