DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and Man2a2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_766491.2	Gene:	Man2a2 / 140481	MGIID:	2150656	Length:	1152	Species:	Mus musculus

Alignment Length:	1097	Identity:	282/1097 - (25%)
Similarity:	461/1097 - (42%)	Gaps:	265/1097 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 INIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKW 101
            :.:.:|||||:|.||:||.|:||...        .|:|:::::|:|.::|.|||:..|.|||:||
Mouse   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   102 WNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVG 166
            |:..|...||.|:.||..|:|:...|.|.|.|||..:|.:::||...|.::|:...|  ..||.|
Mouse   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   167 WQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIW-DASESLSQVKLFTGLLY 230
            |.:||||||.....:..:.........|:.:..|.......:||.:| ...:|.|...:|..::.
Mouse   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSSTDIFCHMMP 350

  Fly   231 TFYWDTPGFC---------FD--------VHC--------------SDDPIIDSDSYDNNVKSRV 264
            .:.:|.|..|         ||        ::|              :|...:..|.|  ..|||:
Mouse   351 FYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQY--RKKSRL 413

  Fly   265 DDFIAYAAQVAEKFRTNHIMIPMGGDFQY---EDAEVNYKNMDKLIKYVNERQSSGSKYNI--IY 324
                         ||:|.:::|:|.||:|   ::.:..:.|..:|..::|    |..::::  .:
Mouse   414 -------------FRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLN----SKPEFHVQAQF 461

  Fly   325 STPTCYLNSVHKSV--------QSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFER------D 375
            .|.:.|.::::|..        ..:|..:.|||.|....:.:|||||||||..|..:|      .
Mouse   462 GTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLR 526

  Fly   376 GNHILQ-----------VAKQ--LSAFAELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSD 427
            |..||.           :|.|  ||.||.|:..         |..:|:.|||||||||.|:.|..
Mouse   527 GAEILYSLALAHARRSGLAGQYPLSDFALLTEA---------RRTLGLFQHHDAITGTAKEAVVV 582

  Fly   428 DYDRILYDAIVGGVKTAGDALRKLTNLPN-----------GEFES--------CLQLN---ISEC 470
            ||          ||:    .||.|.:|..           |:.|:        .||::   :|..
Mouse   583 DY----------GVR----LLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHD 633

  Fly   471 AFTK------DGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVV----------ASEI 519
            |..:      |.:...|| ::|.|.......|.:.|.:...:|..|:|:.:          |:::
Mouse   634 ALPERTVIRLDSSPRFVV-VFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDM 697

  Fly   520 VP------VPAEVLALEFRDSDTQHELVFKASVDKIANYYIKKVD---SKESSNGVRVISQPKAN 575
            ||      ||..:..|.......|.:|....::......|:..|.   |::|:..|||:....:
Mouse   698 VPDVYQVSVPVRLPGLGLGVLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAFPVRVVDSGAS- 761

  Fly   576 AETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQS-------YGLYRTYD-SGAYVFR 632
                   :..:....:::.....|||||.:..  |.|..||.       ||...:.| ||||:|.
Mouse   762 -------DFAISNRYMQVWFSGLTGLLKSIRR--VDEEQEQQMELEFLVYGTRTSKDKSGAYLFL 817

  Fly   633 QYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVE-------FEWLVGPIP 690
            ..::....:.:......|.:|....|| ..:.|:..||||: .:.|.||       |:     :.
Mouse   818 PDSEAKPYVPKKPPVLRVTEGPFFSEV-AVYYEHFHQVIRL-YNLPGVEGLSLDMSFQ-----VD 875

  Fly   691 VEEEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIAL 755
            :.:....|:.....::|.|.|.|:||.||.::..|:..|:         .|...|:||:.....:
Mouse   876 IRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKK---------LPLQANFYPMPVMAYI 931

  Fly   756 QDSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKYGQPLIARGKVFLILN 820
            |||.:||.:...:|.|.:|:.:||:|::|.|||::||..|:|:.|.:.|     |...:..|:|
Mouse   932 QDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKDNK-----ITCNRFRLLL- 990

  Fly   821 AADESTSAEREAEKE-----------FHL--------PLWKFFSKNTGSTTAAAKSVPSFDDFPK 866
              :..|:...|..:|           .||        ||....:|..|::.|.....|.....|.
Mouse   991 --ERRTTMSPEVHQEQERSTSYPSLLSHLTSMYLSTPPLVLPVAKRQGTSPALRSFHPLASPLPC 1053

  Fly   867 SVHLLTLE--------PFNDDEILLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLP 923
            ..|||.|.        |..|..::|..:.|...:|.|.:.||.              ||..|.|.
Mouse  1054 DFHLLNLRMLPAEDTLPATDSALILHRKGFDCGLEAKNLGFNC--------------TTSQGKLA 1104

  Fly   924 LSDMKQFKFHAEGSGIRGSEPEYYTSSHKPLSANQTQDAAEFAVTLYPMQIRTFIIK 980
            |..:    ||  |..:...:|...|..:...|.:.:.|     ::|.||:|.||.::
Mouse  1105 LGSL----FH--GLDVTFLQPTSLTLLYPLASPSNSTD-----ISLEPMEISTFRLR 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	88/308 (29%)
		Alpha-mann_mid	358..433	CDD:286360	36/93 (39%)
		Glyco_hydro_38C	481..977	CDD:285047	133/556 (24%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	282/1097 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810