DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and man2a2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_009296075.1	Gene:	man2a2 / 100333987	ZFINID:	ZDB-GENE-110331-1	Length:	1174	Species:	Danio rerio

Alignment Length:	1102	Identity:	269/1102 - (24%)
Similarity:	454/1102 - (41%)	Gaps:	226/1102 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GYESCHETK---SNMINIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNP 86
            |:|..:|..   ...:.:.:|||||:|.||:||.|:||     |.|   .|:|::.:::::.::|
Zfish   151 GFEITYEPNEWDDEPLQVFVVPHSHNDPGWIKTFDKYY-----NDQ---TQHILNNMVTKMAEDP 207

  Fly    87 DRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLK 151
            .|:||..|.|:|:|||.......:.|::.|:..|:|:.:.|.|.|.|||..:|.::|||...|.:
Zfish   208 RRKFIWSEISYFAKWWESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQ 272

  Fly   152 FLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIW-DA 215
            :|:...||  .||.||.:||||||.....:..:.........|:.::.|.......:||.:| .|
Zfish   273 WLERNLGV--TPRSGWAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQA 335

  Fly   216 SESLSQVKLFTGLLYTFYWDTPGFC---------FD--------VHC--SDDPIIDSDSYDNNVK 261
            .:..|...:|..::..:.:|.|..|         ||        |:|  ...|...:|:   ||.
Zfish   336 WDIESSTDMFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDA---NVA 397

  Fly   262 SRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDA---EVNYKNMDKLIKYVNERQSSGSKYNII 323
            .|....:....:.::.||:..:::|:|.||:|:.|   :..|.|..||..|:|.......|..
Zfish   398 ERAGVLLDQYRKKSKLFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPEMHVKAQ-- 460

  Fly   324 YSTPTCYLNSVHKS--VQS------YPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHIL 380
            ::|.:.|.::|:|:  |.|      ||..:.|||.|....:.:|:|||||||..|..:|.....|
Zfish   461 FATLSDYFDAVYKANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHL 525

  Fly   381 QVAKQLSAFAELSSTQQKEDLEY----------LREIMGVMQHHDAITGTEKQHVSDDYDRILYD 435
            :.|:.|.:.|...:.....:..|          .|..:|:.|||||||||.|:.|..||...|..
Zfish   526 RGAEILYSLAVAHARHAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLR 590

  Fly   436 AIVGGVKTAGDALRKLTNLPNGEFESCLQ----LNISECAFTKDG----------ADNVVVTLYN 486
            ::||..:...:|...|. :.|.:.....|    |...:...|:|.          :....:.|:|
Zfish   591 SLVGLKRVIINAAHFLI-IKNKDIYRFYQTEPFLETDDRRATQDSLPQRTLIELESSPRYLVLFN 654

  Fly   487 ALAHTTKQYVRVPVKNENYQVTDEKGRVVASEIVPVPAEVLALEFRDSDTQHELV---FKASVDK 548
            .:.......|.|.|.:...:|..|.|:.       :|.::.|.....::...|:.   |.|.:..
Zfish   655 PVEQERLCLVTVLVNSARVRVLTEDGQT-------LPVQLSAQWMSATEMSGEVYQASFMARLPA 712

  Fly   549 IANYYIKKVDSKES---------------SNGVRVISQPKANAETYDDEETIVQTSLIKLVLDNK 598
            :........||.:|               ...:|.:......::|.|.:...:|:..:.|.....
Zfish   713 LGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQSQSLTLGFSGA 777

  Fly   599 TGLLKRVEMNGVSENIE-----QSYGLYRTYD-SGAYVF------RQYNQGDFVIQEDGVEFTVY 651
            ||||:.:......:.:.     .:||...:.| ||||:|      :.|:|.:..|      ..|.
Zfish   778 TGLLESIRRKDDPQEVRVQIQFLTYGTRPSKDKSGAYLFLPDGNAKPYSQREAPI------VRVV 836

  Fly   652 DGALVKEVHQRFSEYISQVIRISEDKPYVEFEWL--VGPIPVEEEFGTEVVTIFSSEIASNGVFY 714
            :|.|..||...: ::..|.:|| .:.|.|:...|  ...:.:.::...|:...|.::|.|...||
Zfish   837 EGPLFAEVVAHY-QHFQQTVRI-HNVPGVDGLSLDITTMVDIRDQNNKELAMRFVTDIQSGDTFY 899

  Fly   715 TDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQ 779
            ||.||.::..|...::         .|...|:||:.|...:|||..||.:...:|.|.||:..||
Zfish   900 TDLNGFQIQPRRYFQK---------LPLQANFYPMPSTAYIQDSQYRLTLHTAQALGVTSLASGQ 955

  Fly   780 IELMLHRRLVRDDGYGVGEALNEEK----------------------YG---------------- 806
            :|::|.|||::||..|:|:.|.:.|                      |.
Zfish   956 LEVILDRRLMQDDNRGLGQGLKDNKRTANRFRLLLERRSNSAKPAGSYANMLNKIIAGILGDGQE 1020

  Fly   807 QPLIARGKVFLILNAADESTSAEREA------EKEFHLPLWKFFSKNTGSTTAAAKSVPSFDDFP 865
            :|:.:|...|..|.:...||....|.      .::..:|..:.|:...|:             .|
Zfish  1021 EPVDSRPVSFPSLLSHMTSTILNHEVLALPVLPRKHGVPPMRTFAPLAGT-------------LP 1072

  Fly   866 KSVHLLTLEPFNDDE----------ILLRVENFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDG 920
            ...|||.|......:          :||........:|.:...||.              ||..|
Zfish  1073 CDFHLLNLRSIQSPQDAHSPSPYMALLLHRLGLDCGLEPQNPGFNC--------------TTTQG 1123

  Fly   921 NLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHK--PLSANQTQDAAEFAVTLYPMQIRTFIIK 980
            .|.:|.:  |:    |..::..:|...:..|.  |||.:.       :|:|.||:|..:.:|
Zfish  1124 QLSVSGL--FR----GLDLQLLQPMSLSLMHSQPPLSNDS-------SVSLEPMEISAYKLK 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	88/296 (30%)
		Alpha-mann_mid	358..433	CDD:286360	30/84 (36%)
		Glyco_hydro_38C	481..977	CDD:285047	123/583 (21%)
man2a2	XP_009296075.1	PLN02701	128..1173	CDD:178304	269/1102 (24%)
		CE4_SF	165..508	CDD:301698	104/357 (29%)
		Alpha-mann_mid	503..588	CDD:214875	30/84 (36%)
		Glyco_hydro_38C	741..1169	CDD:285047	107/484 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910