DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManV and man2b2

DIOPT Version :9

Sequence 1:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_001337519.3	Gene:	man2b2 / 100003570	ZFINID:	ZDB-GENE-140106-166	Length:	1006	Species:	Danio rerio

Alignment Length:	1065	Identity:	277/1065 - (26%)
Similarity:	464/1065 - (43%)	Gaps:	205/1065 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 INIHLVPHSHDDVGWLKTVDQYYYGHRNNIQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKW 101
            |...::||||.||||:.||.:..:.:.:|        :..||:.||.:..:|:||.||..||..|
Zfish    23 IQAFVIPHSHMDVGWVYTVQESMHAYASN--------VYSTVVEELTRVKNRKFIAVEQEFFRLW 79

  Fly   102 W-NEQSETMRAVVKMLVNEGRLQFINGAWSMNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRV 165
            | |..|:..:..|:.|:.||||:||.|...|:|||..:....|.|.|.|..||.:||||  |||.
Zfish    80 WTNVASDWHKKQVRQLLLEGRLEFIIGGQVMHDEAVTDVDDAILQLTEGHGFLYETFGV--RPRF 142

  Fly   166 GWQIDPFGHSREQASIYAQMGFDGEFFSRMDHNDKGRRMNDLALEMIWDASESLSQ-VKLFTGLL 229
            .|.:||||.|.....::|..|||....||:|::.|.....:..|:.:|..|.:|.: .::||..:
Zfish   143 AWHVDPFGASATTPVLFALAGFDAHLISRIDYDLKDDMQKNKKLQFVWRGSPTLKEKQEIFTHTM 207

  Fly   230 YTFYWDTP---------GFCFD-VHCSDDPIIDSDSYDNNVKSRVDDFIAYAAQV--------AE 276
            ..|.:.||         ||.:: |....||..|. .|.|.......:.:...||.        |:
Zfish   208 DQFSYCTPSYIPFSNRSGFYWNGVALFPDPPKDG-KYPNMSLPVTKETVELYAQTMVDNIRLRAQ 271

  Fly   277 KFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNII--YSTPTCYLNSVHKSVQ 339
            .||::|::.|.|.|.|:.:|.|.:.|||.|:.|:|   :...:|.:.  |:|...|..::|::..
Zfish   272 WFRSSHVLWPWGCDKQFYNASVQFSNMDVLMNYIN---THSDQYGVTVQYATLKDYFQTLHQTNL 333

  Fly   340 SYPNK-TLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFAELS---STQQKE- 399
            |:..: ..||.||.::....|||:|.||...|...|..:.:|..::.|.....:|   ...|:|
Zfish   334 SWDVRGNQDFLPYSTEPFQAWTGFYGSRNVLKGVARRASSLLYASESLFTRYHISYPDGPVQREW 398

  Fly   400 ---DLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVK-----------TAGDALRK 450
               .|:.||..:..:||||.|||||...|:|.|...|...::|..:           .:.|...:
Zfish   399 ALSKLKALRWAVSEVQHHDGITGTESPKVADMYMEHLLQGMMGAEELLAAIFLLPQTLSNDIYDQ 463

  Fly   451 LTNLPNGEFESCLQLNISECAFTKDGADNVV---VTLYNALAHTTKQYVRVPVKNENYQVTDEKG 512
            :.|.|               ...:..::||.   :.:||.||.....||.|.|:.....|.|:.|
Zfish   464 IKNTP---------------TTARTDSENVPEQHIFVYNPLAWNISTYVNVSVQYAMAVVLDDDG 513

  Fly   513 RVVASEIVPVPAEVLALEFRDSDTQHELVFKASVD--KIANYYIKKVDSK-------ESSNGVRV 568
            :.|.::|.|         ..:|.|.::|.|...:.  :...|.::...|.       .:::..:|
Zfish   514 KAVPAQIQP---------SMESSTVYDLFFVVELGGLQYRKYTVQFPQSPCDTGSACGATHVAKV 569

  Fly   569 ISQPKANAETYDDEET-----IVQTSLIKLVLDNKTGLLKRV--EMNGVSENIEQSYGLYRT--- 623
            :...|.|...:  ::|     .|.....||:.|.:|.||..:  ....:...::|.:..|:.
Zfish   570 VKFNKTNVRQW--KKTGRKLLPVLNECYKLMFDQETNLLHSITDRSKKIRVRVQQDFWEYKANGD 632

  Fly   624 YDSGA----YVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPY----- 679
            ..||.    |:|..  .|..|.....|...:..|.::.|:.|.|       .|..||..:
Zfish   633 VQSGPISDNYIFTA--NGSAVPAYKSVVMEIVPGKVISEIRQYF-------YREEEDANHTYSVV 688

  Fly   680 ---------------VEFEWLVGPIPVEEEFGTEVVTIF--SSEIASNGVFYTDSNGRELIRREK 727
                           :|..:.|||:.|..|      |:|  .:.:.:|...:||:||.::::|..
Zfish   689 TRVPVGFKGRLSCFRLEQSYKVGPLEVNRE------TVFRTRTSLQNNRTLFTDNNGYQMMKRTY 747

  Fly   728 DKREDFTPELAVQPTSGNYYPITSRIALQDSNKRLAILNDRAQGGTSMKDGQIELMLHRRLVR-- 790
            ....:.|       .:.||||:.....::|.:.|:..|::||.|..|:..||:|:||||||..
Zfish   748 KGYANNT-------VARNYYPMVRVAYMEDESSRVVFLSERAHGVASLSQGQLEVMLHRRLWNNQ 805

  Fly   791 --DDGYGVGEALNEEKYGQPLIARGKVFLILNAADESTSA-EREAEKEFHLPLWKFFSK-----N 847
              :.||.:  .||:....:|::     :::|.:.|..:|. ::||.:..|.|:.....:     |
Zfish   806 EWNQGYNL--TLNDSSVVRPVL-----WMMLGSPDSLSSIYQQEAVELQHRPVVMAIDQPQKLLN 863

  Fly   848 TGSTTAAAKSVPSFDDFPKSVHLLTL------------------EPFNDDEILLRVENFKDHIEG 894
            ...|.:.....|..  .|:::|:.:|                  ...|.|.||||:.:..:..|.
Zfish   864 QRETFSGPSVHPVV--LPQNLHMQSLSIPGWNYSPEHSSGGDEKSEVNFDRILLRITHLYEEGES 926

  Fly   895 KVVS----FNIRPIFDYLNGV-EIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSHKPL 954
            .|:|    .|::.:...:..| :::|.:|.|...:||::::.:..:         |....:.|..
Zfish   927 PVLSQPTTINLKEVMQGIGKVSKVQECSLTGTWNISDLQRWNWKTD---------ETMQKTDKSG 982

  Fly   955 SANQTQDAAEFAVTLYPMQIRTFII 979
            .:..|||   |.||:.|.:||||.|
Zfish   983 FSGVTQD---FNVTISPKEIRTFFI 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	101/293 (34%)
		Alpha-mann_mid	358..433	CDD:286360	28/81 (35%)
		Glyco_hydro_38C	481..977	CDD:285047	127/576 (22%)
man2b2	XP_001337519.3	PLN02701	20..1002	CDD:178304	274/1061 (26%)
man2b2	XP_001337519.3	GH38-57_N_LamB_YdjC_SF	23..348	CDD:330225	112/338 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920