DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and man2b1

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_001072469.1	Gene:	man2b1 / 779924	XenbaseID:	XB-GENE-958698	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	1007	Identity:	427/1007 - (42%)
Similarity:	595/1007 - (59%)	Gaps:	68/1007 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILFLSILLVLFA---KQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIH 68
            :|.|.:||:..|   ||:|. ||.:|||:.....:|:||:||:||||||||||||.|||..|.|.
Frog     6 LLLLPLLLLGAAGRLKQAEG-CGEQSCPQAPDGFLNVHLIPHTHNDVGWLKTVDQYYYGAHNDIQ 69

  Fly    69 HAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMN 133
            ||||||||||||||||.||.:|||.||:|||.:||..|.|.:::.||:||.|||.||..|.||||
Frog    70 HAGVQYILDSVVSQLLHDPSKRFIYVESAFFWRWWKQQDELVRRDVTRLVEEGRLEFINGGWSMN 134

  Fly   134 DEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDH 198
            |||..:|..:|||.|:||:||..|||.||||||.|.||.||||||||.:||.|||||.||.|:|:
Frog   135 DEAATHYSSIIDQMTLGLQFLKSTFGDCGRPRVAWHIDPFGHSREQALLFAQMGYDGFFFGRLDY 199

  Fly   199 NDKDTRMNDLTMEMIWDASESMSG--VSLFSGMLYNFYSDTPGFCFDILCTDQPIIDGDS-EENN 260
            .||..|.....|||:|.||:.:|.  ..||:|:|.|.|:...|||:|.||.|.||||..| |:.|
Frog   200 QDKANREKTKQMEMLWRASDDISPPYADLFTGVLPNGYNPPDGFCWDQLCDDTPIIDDPSVEDYN 264

  Fly   261 VKQRVDDFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQASGSKYNIFY 325
            ....|..|:..|...::.|:::||::.||.|||||:|.:.:||||:|||.:|.:|.:|||.|:||
Frog   265 ADVIVQKFLKAATQQAQKYLSSHIVMTMGSDFQYENAIMWFKNMDRLIKNVNMQQINGSKVNVFY 329

  Fly   326 STPSCYLNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVL 390
            |||||||.|||::..:||.|..||||||...:.||||:|||||..|.:||..|:.|||..|:..|
Frog   330 STPSCYLQSLHRANLTWPMKMDDFFPYADGPHMFWTGYFTSRPAFKGYERLSNNFLQVCNQMEAL 394

  Fly   391 ANLTSEE---HKIDLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDALRLL 452
            :.|.:..   .:.....:|:.|||.|||||:|||.||.|::||...:.|..........::|..|
Frog   395 SGLEARNGPYGQSSSTVMRRAMGVAQHHDAVTGTAKQHVNNDYSLRLSEGWDSCQVVISNSLSSL 459

  Fly   453 TNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQVTDEKGRTVP 517
            |... ..|..|..||||.|..| :.|:|..|.|||||..|.|..||:||....|:|......|||
Frog   460 TGTK-ENFAFCNLLNISVCHVT-ETANNFKVYLYNPLGRSVTWTVRLPVNGHAYKVIGPNDETVP 522

  Fly   518 SEVVPVPWQVLALEYRSNDTQHELVFKATVNKV--SSYSIKKVESSE---VKHSSIKKINPREDN 577
            ||||.|.....||.::....:.||:|:..:..|  ||:::.|:...:   :|....||   :.|.
Frog   523 SEVVDVSDFTKALRFQQGGAERELIFQGQIPAVGFSSFTVGKLSLPDRFVIKGKRGKK---QPDK 584

  Fly   578 NSETVVENSVVKLVMDNHTGRLKSVE--MNGVSEKIVQNFGVY--------KSHTSCAYTFRQDG 632
                 ::|...::..|..||.:..:.  ...:|..:.|:|..|        .|..|.||.||.:.
Frog   585 -----IQNQYYRVDFDPETGLISGIHNLEKKISLPLKQSFYWYNASVGNEESSQPSGAYIFRPNN 644

  Fly   633 --DIELFENDFEFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPIPIDDKLGSEFV 695
              .:.:.::...:.| :.|||:||||:.:.|.|||:|:|.....:||||.|||:||.|:.|.|.:
Frog   645 SDSVPVSQHVRSYLV-QNSLVQEVHQNFSSWCSQVVRLYRDQRYIELEWTVGPVPIGDEWGKEVI 708

  Fly   696 TNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLL 760
            :..::.:.::||||||||||:::||.:|.||.:..: ..:|::||:|||.|||.::....::.:|
Frog   709 SLIETNLKTDGVFYTDSNGRQILKRRRDSRETWKLN-QTEPIAGNYYPVNSRIYIKGKNTQVTVL 772

  Fly   761 NDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNET-QYGKGLIARGKLYLILDSATDGDTVT 824
            .||||||:|:.||:||:::|||.|.:|..||||.|.|. ..|:|::.||:..|:||.| |....|
Frog   773 TDRSQGGSSIRDGSLELMVHRRLLRDDYRGVGEPLLENGLLGEGIVVRGRHLLLLDHA-DEAADT 836

  Fly   825 ERKTEKELFLPFWKFFSKTGGVEI----TPSKSLPDFN-DLPQSVHLLTLEFFSEQEILIRFEHF 884
            .|....:.::......|...|:..    ||.:.....| :|||:.||||....:..:||:|.||.
Frog   837 HRTLALQQYMSPQVVLSSGDGIPYSQSGTPKRKFSALNGELPQNGHLLTFAMHAADKILLRLEHP 901

  Fly   885 L----DKSEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTKPSSVEYSTA 945
            .    .|:..:.|:.|:..:|.|:......||||..||..|.:||              :::.|.
Frog   902 FQSQESKNNSQPITINLNTLFSSVSLSNFEETTLGANMEKSRLKR--------------LQWRTR 952

  Fly   946 QHKPLEAVKSDEASLF---AVTLYPMQIRTFI 974
            ...||: :.|..|.:.   .:||.||:||||:
Frog   953 TGSPLQ-MDSPRAPVVDPSNITLSPMEIRTFL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	160/275 (58%)
		Alpha-mann_mid	359..434	CDD:214875	36/77 (47%)
		Glyco_hydro_38C	483..973	CDD:285047	175/519 (34%)
man2b1	NP_001072469.1	PLN02701	39..987	CDD:178304	414/973 (43%)
man2b1	NP_001072469.1	GH38N_AMII_LAM_like	39..317	CDD:212121	160/277 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I465
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm47730
Panther	1	1.100	-	-	O	PTHR11607
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160