DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and man2b1

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	XP_005169420.1	Gene:	man2b1 / 541519	ZFINID:	ZDB-GENE-050327-52	Length:	984	Species:	Danio rerio

Alignment Length:	1018	Identity:	429/1018 - (42%)
Similarity:	603/1018 - (59%)	Gaps:	98/1018 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILFLSILLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAG 71
            :||...|:........::|||:|||.||.:|:|:|||||:|:||||||||||.:||.:|.|.|||
Zfish    13 LLFCFSLVFSLPTGRNSICGYKSCPATKPSMLNVHLVPHTHDDVGWLKTVDQYFYGDRNNIQHAG 77

  Fly    72 VQYILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEA 136
            ||||||||:.||.:||.||||.||||||.:||..|:::.:::||:||||||.||..|.|.|:|||
Zfish    78 VQYILDSVIDQLQKDPARRFIYVETAFFYRWWRQQNQNTRRIVTQLVNEGRLEFINGGWCMSDEA 142

  Fly   137 NVNYQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDK 201
            ..:|..||||.|:||:|||:|||.||||||.|.||.|||:||.|:|||.|||||.||.|:|:.||
Zfish   143 TTHYSAVIDQMTLGLRFLNDTFGECGRPRVAWHIDPFGHAREHASIFAQMGYDGFFFGRLDYQDK 207

  Fly   202 DTRMNDLTMEMIWDASESMSG--VSLFSGMLYNFYSDTPGFCFDILCTDQPIIDG-DSEENNVKQ 263
            |.||....|||:|.||||::.  ..||:|:|.|.|:...|||:|..|.|.||.|. |.|:.||.:
Zfish   208 DRRMKTKEMEMLWRASESLTPPIADLFTGVLPNGYNPPEGFCWDQSCDDAPIRDDPDLEDYNVDE 272

  Fly   264 RVDDFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQASGSKYNIFYSTP 328
            .|..|::.:...::.|.||||::.||.|||||:|.:.||||||||||:|..||.|||.|:.||||
Zfish   273 IVQKFLNASHKQADYYKTNHIIMTMGSDFQYENANLWYKNMDKLIKYVNALQAKGSKLNVLYSTP 337

  Fly   329 SCYLNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANL 393
            ||||..|:.:..:||.||.||||||.:.:.||||:|||||..|.:||..|..||...||.||...
Zfish   338 SCYLQELNLANFTWPMKTDDFFPYADDAHDFWTGYFTSRPALKLYERLSNSRLQTCNQLEVLGGP 402

  Fly   394 TSEEHKI---DLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMM------YEAIVG---ASNNAR 446
            ||.....   |.|.:|:.|||.|||||::|||||.|::||.|.:      .|.:|.   |..:..
Zfish   403 TSTSGPFGEGDSDTMRRAMGVAQHHDAVSGTEKQHVANDYARRLATGWAHCEVLVSNSLAVLSGS 467

  Fly   447 DALRLLTNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQVTDE 511
            :|.|:.          |..||||.|..| :.:....:.:||||..:....||:||....|.|||.
Zfish   468 EAPRVF----------CENLNISVCPLT-ESSHKFSMNVYNPLGRTVRWPVRLPVNGSVYNVTDA 521

  Fly   512 KGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKV--SSYSIKKVESSEVKHSSIKKINP- 573
            .|:.|.|||:|:......:.......:.||||:.....:  |:|.|..|:...          |
Zfish   522 NGKAVDSEVIPLSKSRKEVRQNRGFAKSELVFQVEAPPLGYSTYIISMVQDQP----------PV 576

  Fly   574 -REDNNSETVVENSVVKLVMDNHTGRLKSVEMNGVSE--KIVQNFGVY--------KSH-TSCAY 626
             |..|...:.::|..:|:..|:.||.|.|:......:  ::.|||..|        :|| .|.||
Zfish   577 SRSKNAVPSSIQNKFLKVTFDSTTGLLSSLTNLETQQTIRLTQNFFWYNASAGNNKESHQPSGAY 641

  Fly   627 TFR-QDGDIELFENDFEF---TVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPIPID 687
            .|| ...|..:.....|.   ::|..  |:||.|..:.|:|||:|:||....:||||.|||:|::
Zfish   642 IFRPNSSDPFIISKTAEIQAVSLYNS--VQEVTQRFSPWVSQVVRLYEDRRELELEWTVGPVPVE 704

  Fly   688 DKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSR-QPVSGNFYPVTSRIALQ 751
            |.||.|.:|...::|.|:|.|||||||||:::|.||.|..:  ||.: :|::||:||:.||..::
Zfish   705 DGLGKEVITRLDTDIQSSGYFYTDSNGREVLERRKDYRPTW--DLKQTEPIAGNYYPINSRAYIK 767

  Fly   752 DDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNET-QYGKGLIARGKLYLIL- 814
            ||.::|.::.|||||.:|:.:|:||:::|||.|::|..||||.|:|. ::..||:|||:|.|.|
Zfish   768 DDKRQLTVVTDRSQGASSIYNGSLEIMLHRRLLYDDFRGVGEPLSEPGEFAHGLVARGRLLLTLS 832

  Fly   815 --DSATDGDTVTERKTEKELFL-PFWKFFSKTGGVEITPSKSLPDFND----LPQSVHLLTLEFF 872
              ::|.|    ..|...:.:.| |...|  :.|..  :|...| :|:.    ||.:|||||:..:
Zfish   833 PPEAAAD----LHRPLAQSMVLQPLLSF--QDGAP--SPGTKL-EFSGLQAALPPAVHLLTVSQW 888

  Fly   873 SEQEILIRFEHFLDKSEGRV----ISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQES 933
            .:..:|:|.||.....|.:.    ::.|::.:|.:|..|...|.:|..|....||.|..::.::.
Zfish   889 DQDSVLVRLEHQYQAKESKTHSQPVTVNLQKLFSTLQVLGASEMSLGANQWKEDMIRLHWNTEKD 953

  Fly   934 GTKPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976
            ...|      ||:          :.|.:.|||.||:||||:::
Zfish   954 ALPP------TAR----------DPSSWEVTLKPMEIRTFLLR 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	163/275 (59%)
		Alpha-mann_mid	359..434	CDD:214875	41/77 (53%)
		Glyco_hydro_38C	483..973	CDD:285047	173/522 (33%)
man2b1	XP_005169420.1	PLN02701	44..982	CDD:178304	417/987 (42%)
		GH38N_AMII_LAM_like	44..322	CDD:212121	163/277 (59%)
		Alpha-mann_mid	368..446	CDD:214875	41/77 (53%)
		Glyco_hydro_38C	558..977	CDD:285047	151/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581805
Domainoid	1	1.000	82	1.000	Domainoid score	I8330
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.720