Protein Alignment LManIV and MAN2A2

DIOPT Version :10

• Sequence 1: NP_609251.2
• Gene: LManIV / 34204
• FlyBaseID: FBgn0032067
• Length: 978
• Species: Drosophila melanogaster
• Sequence 2: NP_001307906.1
• Gene: MAN2A2 / 4122
• HGNCID: 6825
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 1101
• Identity: 280/1101 - (25%)
• Similarity: 459/1101 - (41%)
• Gaps: 249/1101 - (22%)

  Fly    35 ANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFF 99
            |..:.:.:|||||||.||:||.|: ||..:       .|:||:|:||:|.:||:|||:..|.:||
Human   163 AEDLQVFVVPHSHNDPGWIKTFDK-YYTEQ-------TQHILNSMVSKLQEDPRRRFLWAEVSFF 219

  Fly   100 AKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRP 164
            ||||:..:...:..|.:||..|:.|...|.|.|.||||.:|..:|||...|.::|....|:  .|
Human   220 AKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGA--TP 282

  Fly   165 RVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDAS-ESMSGVSLFSG 228
            |.||.:|.||:|.....:............|:.:..|.......::|.:|..: :|.|...:|..
Human   283 RSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCH 347

  Fly   229 MLYNFYS-DTPGFCF---DILCT-DQPIIDGDS------------EENNVKQRVDDFISYAKNVS 276
            |: .||| |.|..|.   .|.|. |...:.|..            .|.||.:|....:...:..|
Human   348 MM-PFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKS 411

  Fly   277 EVYITNHIMVPMGGDFQYE-----DAKVNYKNMDKLIKYINER-----QASGSKYNIFYSTPSCY 331
            :::.:|.::||:|.||:|:     ||:  :.|..:|..:.|.|     ||.       :.|.|.|
Human   412 QLFRSNVLLVPLGDDFRYDKPQEWDAQ--FFNYQRLFDFFNSRPNLHVQAQ-------FGTLSDY 467

  Fly   332 LNSLHQSL--------ESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLS 388
            .::|::..        ..:|..:.|||.||..::.:|||::||||..|..:|.....|:.|:.|.
Human   468 FDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLY 532

  Fly   389 VLA-------NLTSEEHKIDLDYL---RQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASN 443
            .||       .|.......|...|   |:.:|:.|||||||||.|:||..||...:..::|....
Human   533 SLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQ 597

  Fly   444 ---NARDALRLLTNMPYGEFESCLRLNISECAFTKDG----------ADNVLVTLYNPLAHSSTQ 495
               :|...|.|.....|........|.:.:...:.|.          :....|.|:|||......
Human   598 VIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFS 662

  Fly   496 YVRIPVKEENYQVTDEKGRTV----------PSEVVPVPWQV-----------------LALE-Y 532
            .|.:.|.....:|..|:|:.:          .:|.||..:||                 |.|: :
Human   663 MVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQLQLGLDGH 727

  Fly   533 RSNDTQHELVF---KATVNKVSSYSIKKVESSEVKHSSIKKINPREDNNSETVVENSVVKLVMDN 594
            |:..:...:..   :.:|::..::.::.::|                ..|:..:.|..:::....
Human   728 RTLPSSVRIYLHGRQLSVSRHEAFPLRVIDS----------------GTSDFALSNRYMQVWFSG 776

  Fly   595 HTGRLKSVEMNGVSEKIVQNFG----VYKSHT----SCAYTFRQDGDIELF--ENDFEFTVYEGS 649
            .||.|||:..  |.|:..|...    ||.:.|    |.||.|..||:.:.:  :......|.||.
Human   777 LTGLLKSIRR--VDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGP 839

  Fly   650 LVKEV---HQHVNDWISQVIRIYE--GVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFY 709
            ...||   ::|::    |.:|:|.  ||..:.|: :...:.|.|.:..|...:..::|.|.|:|:
Human   840 FFSEVVAYYEHIH----QAVRLYNLPGVEGLSLD-ISSLVDIRDYVNKELALHIHTDIDSQGIFF 899

  Fly   710 TDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGA 774
            ||.||.::..|         ..|.:.|:..||||:.....:||..|||.|...::.|.:||:||.
Human   900 TDLNGFQVQPR---------RYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQ 955

  Fly   775 LEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTERKTEKELFLPFWKF 839
            ||:::.||.:.:|..|:|:.|.:.:.     ...:..|:|:..|.|       :|.:.|......
Human   956 LEVILDRRLMQDDNRGLGQGLKDNKR-----TCNRFRLLLERRTVG-------SEPDFFSKLAAM 1008

  Fly   840 F-------SKTGGVEITPSKSL-------------------------------------PDFNDL 860
            |       |::|..|:..|.|.                                     |..:.|
Human  1009 FRGLIFHSSRSGNREVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGPGLRSFHPLASSL 1073

  Fly   861 PQSVHLLTLEFFSEQE---------ILIRFEHFLDKSEGRVISFNIRDIFDSLGGLAIRETTLDG 916
            |...|||.|.....:|         :::..:.|....|.:.:.||.              ||..|
Human  1074 PCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAKNLGFNC--------------TTSQG 1124

  Fly   917 NMPLSDMKRFKFHAQE-SGTKPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976
            .:.|..:    ||..: ...:|:|:   |..: || |..|:...::   |.||:|.||.::
Human  1125 KVALGSL----FHGLDVVFLQPTSL---TLLY-PL-ASPSNSTDVY---LEPMEIATFRLR 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	PLN02701	31..793	CDD:178304	235/862 (27%)
		GH38N_AMII_LAM_like	39..312	CDD:212121	94/295 (32%)
MAN2A2	NP_001307906.1	PLN02701	136..1174	CDD:178304	280/1101 (25%)