DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and ams1

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_593979.1	Gene:	ams1 / 2543485	PomBaseID:	SPAC513.05	Length:	1077	Species:	Schizosaccharomyces pombe

Alignment Length:	943	Identity:	181/943 - (19%)
Similarity:	324/943 - (34%)	Gaps:	296/943 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SEAVCGYESCPETKANMVNIHLVPHSHNDVGWL-------KTVDQSYYGYKNKIHHAGVQYILDS 78
            ||||.      |...:..|:..:.|.|.|..||       :.:.:|:....|         |:|
pombe   270 SEAVF------EKNNDKANVFAIGHCHIDTAWLWPFAETRRKIVRSWATQMN---------IMD- 318

  Fly    79 VVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGV 143
                  :.|:.:|: ...|....|.......:.:.:.:.||:.:|...||:|..:|....|.:.:
pombe   319 ------RYPEYQFV-CSQALQYLWLKEDHPDVFEKLKEYVNQNKFIPIGGSWVEHDTNIPNGESL 376

  Fly   144 IDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDL 208
            |.||.:|..|..:.||.  |.|..|..||||:|.:...|....|.| :|               |
pombe   377 IRQFLLGQHFFEKEFGV--RCRTFWLPDTFGYSSQIPQICRLCGMD-RF---------------L 423

  Fly   209 TMEMIWDASESMSGVSLFSGMLYNFYSDTPGFCFD---ILCTDQP--IIDGDSEENNVKQRVDDF 268
            |.::.|      :.::.|....:|:.:      .|   ::|...|  ....|:..|:|...:|..
pombe   424 TQKLSW------NNINSFPTSTFNWVA------LDGSQVICHMPPANTYTADTNVNDVLHSIDQH 476

  Fly   269 ISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQASGSKYNIFYSTPSCYL- 332
            .:...:.:.:.:..   :..||.....:.      ::||      |:..|....:.| .|:..|
pombe   477 KNLVNDQAGLLVFG---IGDGGGGPTPEM------LEKL------RRCKGIANTVGY-LPNVKLG 525

  Fly   333 -------------NSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVA 384
                         .:..|:|.||..:.  :|       .|..|.:|::...|:..|.....|..|
pombe   526 NTVDEFFDGILKRTNAGQTLPSWNGEL--YF-------EFHRGTYTTQAELKKLMRKVEIALHDA 581

  Fly   385 KQLSVLANLTSEEHKIDLDYLRQVMG---VMQHHDAITGTEKQAVSDD-----------YDRMMY 435
            :.:|.||::.|:::....:.|:.:..   :.|.||.:.|:..:.|..|           .:.:::
pombe   582 EYVSTLASIFSKDYSYPKESLQDLWRDTLLCQFHDVLPGSCIEMVYKDAIPIMSKVLKNTEALLW 646

  Fly   436 EAI------VGASNNARDALRLLTNMPYG--------------EFESCLRLNISECAFTKDGADN 480
            :||      ..:|::.::.|.||..:|:.              .||||            || ..
pombe   647 QAIEQLGFKKASSSDNKEQLCLLNTLPWNVRGVITETEENKLVYFESC------------DG-KG 698

  Fly   481 VLVTLYNPLAHSSTQYVRIPVKEENY---------------------------QVTDEK------ 512
            :|...:..|.|.:..|    .|::|:                           ::.|.|
pombe   699 ILTAAHTSLKHPAAAY----QKDDNFILVNDHLRVTIAPNGLILSLFDLHKEREILDLKSGKNHA 759

  Fly   513 --GRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKVSSYSIKKVESSEVKHSSIKKINPRE 575
              .:.|..|..|:.||..       ||:             .:|::|.|..:....|||:..|.
pombe   760 GANQYVLFEDTPLSWQAW-------DTE-------------VFSLEKYEVLDKGKVSIKESGPL- 803

  Fly   576 DNNSETVVENSVVKLVMDNHTGRLKSVE-MNGVSEKIVQNFGVYKS-HTSCAYTFRQDGDIELFE 638
              .:..||:..:.:|   :|.....|:| .|..||....||..... |.||.: .:.:..:::..
pombe   804 --RASVVVDIPISEL---SHMKATISLEGYNDCSEFTGVNFTCEVDWHESCKF-LKVEFPVDIHS 862

  Fly   639 NDFEFTVYE---GSLVKEVHQHVNDWISQVIRIYEGVSRVEL---------EWMVGPIPIDD-KL 690
               ||..||   |...:..|.:.: |         .|::.|:         ::..|...::| |.
pombe   863 ---EFASYETQFGITKRPTHYNTS-W---------DVAKFEVCHQKFADYSDFTYGVSVLNDCKY 914

  Fly   691 GSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTK 755
            |                |.|..|...|......|:.|..:|:.:..:....||.:.  .|...|.
pombe   915 G----------------FSTHGNLMRLSLLRSPKQPDAHADMGKHTIRYAVYPHSK--PLDSSTV 961

  Fly   756 RLV-------LLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEA------LNETQYGKGLIAR 807
            |..       .|..|:...|:|:            :|:....|||.      :...:.||.:|.|
pombe   962 RAAHKFNSNFRLLTRASDTANLD------------IFDAFQLVGEPNVILSHIKMAEKGKSIILR 1014

  Fly   808 --------GKLYLILDSATDGDTVTERKTEKEL 832
                    .:..|::.|.|..........|::|
pombe  1015 VYESLGGKSRARLVIKSLTVASVTKCNGLEEDL 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	57/284 (20%)
		Alpha-mann_mid	359..434	CDD:214875	18/88 (20%)
		Glyco_hydro_38C	483..973	CDD:285047	77/421 (18%)
ams1	NP_593979.1	AMS1	44..1077	CDD:223460	181/943 (19%)
		GH38N_AMII_ScAms1_like	282..538	CDD:212123	62/318 (19%)
		Alpha-mann_mid	555..634	CDD:286360	18/78 (23%)
		Glyco_hydro_38C	664..1073	CDD:285047	88/471 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910