DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and Man2a1

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	NP_032575.2	Gene:	Man2a1 / 17158	MGIID:	104669	Length:	1150	Species:	Mus musculus

Alignment Length:	1064	Identity:	267/1064 - (25%)
Similarity:	455/1064 - (42%)	Gaps:	207/1064 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAKW 102
            :.:.:|||||||.|||||.: .|:..|       .|||.:::|.:|.:|..|:|:..|.::.|||
Mouse   165 LQVFVVPHSHNDPGWLKTFN-DYFRDK-------TQYIFNNMVLKLKEDSSRKFMWSEISYLAKW 221

  Fly   103 WNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRVG 167
            |::.....|:.|..|:..|:.|...|.|.|.|||..:|..:|||...|.::|.:..|.  :||.|
Mouse   222 WDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEKNLGV--KPRSG 284

  Fly   168 WQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDASESMSGVSLFSGMLYN 232
            |.||.||||...|.:....|:......|:.:..|.......|:|..|..:..:...:.....:..
Mouse   285 WAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLGSATDILCHMMP 349

  Fly   233 FYS-DTPGFC---------FDIL--------C----TDQPIIDGDSEENNVKQRVDDFISYAKNV 275
            ||| |.|..|         ||..        |    ..:.|..|     ||:.|....:...:..
Mouse   350 FYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPG-----NVQSRAQMLLDQYRKK 409

  Fly   276 SEVYITNHIMVPMGGDF---QYEDAKVNYKNMDKLIKYINERQASGSKYNIFYSTPSCYLNSLHQ 337
            |:::.|..::.|:|.||   :|.:..:..:|.::|..|:|.:  ...|..|.:.|.|.|.::|.:
Mouse   410 SKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQ--PHLKVKIQFGTLSDYFDALEK 472

  Fly   338 SLES--------WPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANLT 394
            ::.:        :|..:.|||.||...:.:|:|:|||||..||.:|.....::.|:.|..||...
Mouse   473 AVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAAEILYQLALKQ 537

  Fly   395 SEEHKID----------LDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDAL 449
            ::::||:          |...|:.:|:.|||||||||.|..|..||...:::::........|:.
Mouse   538 AQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSA 602

  Fly   450 RLLTNMPYGEFES-----CLRLNISECAFTKDGADNVL---------------VTLYNPLAHSST 494
            .||.......::|     .|.::      ||..:.:.|               :.:|||......
Mouse   603 FLLILKDKKLYQSDPSKAFLEMD------TKQSSQDSLPQKIIIQLSAQEPRYLVVYNPFEQERH 661

  Fly   495 QYVRIPVKEENYQVTDEKGRTVPSEVVPVPWQVLALEYRS-NDTQHELVFKATVNKVSSYSIKKV 558
            ..|.|.|.....:|..:.|:.|..:|..| |.    :.|: :...:|:.|.|.:..:.....|.:
Mouse   662 SVVSIRVNSATVKVLSDSGKPVEVQVSAV-WN----DMRTISQAAYEVSFLAHIPPLGLKVFKIL 721

  Fly   559 ESSEVKHSSIKKINPREDNNSETVVENSV--VKLVMDNHTGRLKSVE---------MNGVSEKIV 612
            ||    .||...:......|::.:.||.:  ||.::|  .|...::|         .:|:.||:.
Mouse   722 ES----QSSSSHLADYVLYNNDGLAENGIFHVKNMVD--AGDAITIENPFLAIWFDRSGLMEKVR 780

  Fly   613 QN--------------FG-VYKSHTSCAYTFRQDGDIELFEN---DFEFTVYEGSLVKEVH---Q 656
            :.              :| ..|...|.||.|..||..:.:.:   .| ..|..|.:..:|.   :
Mouse   781 RKEDSRQHELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSLRPPF-VRVTRGRIYSDVTCFLE 844

  Fly   657 HVNDWISQVIRIY--EGVSRVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMK 719
            ||    :..:|:|  :|:....:| :...:.|.:....|.|....|:|::...:|||.||.::..
Mouse   845 HV----THKVRLYNIQGIEGQSME-VSNIVNIRNVHNREIVMRISSKINNQNRYYTDLNGYQIQP 904

  Fly   720 RVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHL 784
            |         ..:|:.|:..|.||:.:...:||...||.||:.:|.|.:|:..|.:|:.:.||.:
Mouse   905 R---------RTMSKLPLQANVYPMCTMAYIQDAEHRLTLLSAQSLGASSMASGQIEVFMDRRLM 960

  Fly   785 FNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTERKTE---------------KELFL 834
            .:|..|:|:.:::.:     |......::|:..:..:...|:|:.               ...||
Mouse   961 QDDNRGLGQGVHDNK-----ITANLFRILLEKRSAVNMEEEKKSPVSYPSLLSHMTSSFLNHPFL 1020

  Fly   835 PFWKFFSKTGGVEITPSKSLPDF----NDLPQSVHLLTL--------EFFSEQEILIRFEHFLDK 887
            |    ...:|.:.....:.|.:|    :.||..:||:.|        :.:|::..||......|
Mouse  1021 P----MVLSGQLPSPAFELLSEFPLLQSSLPCDIHLVNLRTIQSKMGKGYSDEAALILHRKGFD- 1080

  Fly   888 SEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTKPSSVEYSTAQHKPLEA 952
                 ..|:.|       |:.:..:|..|.|  |.:|.|...|.|| ..|||:   :..|.|.:|
Mouse  1081 -----CQFSSR-------GIGLPCSTTQGKM--SVLKLFNKFAVES-LVPSSL---SLMHSPPDA 1127

  Fly   953 VKSDEASLFAVTLYPMQIRTFIIK 976
            ....|     |:|.||:|.||.|:
Mouse  1128 QNMSE-----VSLSPMEISTFRIR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	86/297 (29%)
		Alpha-mann_mid	359..434	CDD:214875	32/84 (38%)
		Glyco_hydro_38C	483..973	CDD:285047	125/551 (23%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	267/1064 (25%)
		GH38N_Man2A1	164..507	CDD:212131	101/358 (28%)
		Alpha-mann_mid	502..587	CDD:214875	32/84 (38%)
		Glyco_hydro_38C	757..1143	CDD:285047	97/433 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810