DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIV and man2b2

DIOPT Version :9

Sequence 1:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster
Sequence 2:	XP_001337519.3	Gene:	man2b2 / 100003570	ZFINID:	ZDB-GENE-140106-166	Length:	1006	Species:	Danio rerio

Alignment Length:	1083	Identity:	277/1083 - (25%)
Similarity:	479/1083 - (44%)	Gaps:	207/1083 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLVLFAKQSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILD 77
            ||::...:::|           |..:...::||||.||||:.||.:|.:.|.:.::        .
Zfish     9 LLLMTVSENDA-----------AEKIQAFVIPHSHMDVGWVYTVQESMHAYASNVY--------S 54

  Fly    78 SVVSQLLQDPKRRFIQVETAFFAKWW-NVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQ 141
            :||.:|.:...|:||.||..||..|| ||.|:..||.|.:|:.|||.||..|...|:|||..:..
Zfish    55 TVVEELTRVKNRKFIAVEQEFFRLWWTNVASDWHKKQVRQLLLEGRLEFIIGGQVMHDEAVTDVD 119

  Fly   142 GVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMN 206
            ..|.|.|.|..||.||||.  |||..|.:|.||.|.....:||..|:|....||:|::.||....
Zfish   120 DAILQLTEGHGFLYETFGV--RPRFAWHVDPFGASATTPVLFALAGFDAHLISRIDYDLKDDMQK 182

  Fly   207 DLTMEMIWDASESM-SGVSLFSGMLYNF---------YSDTPGFCFD-ILCTDQPIIDGDSEENN 260
            :..::.:|..|.:: ....:|:..:..|         :|:..||.:: :.....|..||.....:
Zfish   183 NKKLQFVWRGSPTLKEKQEIFTHTMDQFSYCTPSYIPFSNRSGFYWNGVALFPDPPKDGKYPNMS 247

  Fly   261 VKQRVDDFISYAKNV-------SEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQASG 318
            :....:....||:.:       ::.:.::|::.|.|.|.|:.:|.|.:.|||.|:.|||   ...
Zfish   248 LPVTKETVELYAQTMVDNIRLRAQWFRSSHVLWPWGCDKQFYNASVQFSNMDVLMNYIN---THS 309

  Fly   319 SKYNIF--YSTPSCYLNSLHQSLESWPNK-TQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHM 380
            .:|.:.  |:|...|..:|||:..||..: .|||.||:.|....||||:.||...|...|..:.:
Zfish   310 DQYGVTVQYATLKDYFQTLHQTNLSWDVRGNQDFLPYSTEPFQAWTGFYGSRNVLKGVARRASSL 374

  Fly   381 LQVAKQLSVLANLTSEEHKIDLDY-------LRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAI 438
            |..::.|....:::..:..:..::       ||..:..:||||.|||||...|:|.|...:.:.:
Zfish   375 LYASESLFTRYHISYPDGPVQREWALSKLKALRWAVSEVQHHDGITGTESPKVADMYMEHLLQGM 439

  Fly   439 VGA--------------SNNARDALRLLTNMPYGEFESCLRLNISECAFTKDGADNV---LVTLY 486
            :||              ||:..|.::   |.|               ...:..::||   .:.:|
Zfish   440 MGAEELLAAIFLLPQTLSNDIYDQIK---NTP---------------TTARTDSENVPEQHIFVY 486

  Fly   487 NPLAHSSTQYVRIPVKEENYQVTDEKGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVN--K 549
            ||||.:.:.||.:.|:.....|.|:.|:.||:::.|      ::|   :.|.::|.|...:.  :
Zfish   487 NPLAWNISTYVNVSVQYAMAVVLDDDGKAVPAQIQP------SME---SSTVYDLFFVVELGGLQ 542

  Fly   550 VSSYSIKKVES-----------SEVKHSSIKKINPRE---DNNSETVVENSVVKLVMDNHTGRLK 600
            ...|:::..:|           ...|.....|.|.|:   .......|.|...||:.|..|..|.
Zfish   543 YRKYTVQFPQSPCDTGSACGATHVAKVVKFNKTNVRQWKKTGRKLLPVLNECYKLMFDQETNLLH 607

  Fly   601 SV--EMNGVSEKIVQNFGVYKSH-------TSCAYTFRQDGDIELFENDFEFTVYEGSLVKEVHQ 656
            |:  ....:..::.|:|..||::       .|..|.|..:|............:..|.::.|:.|
Zfish   608 SITDRSKKIRVRVQQDFWEYKANGDVQSGPISDNYIFTANGSAVPAYKSVVMEIVPGKVISEIRQ 672

  Fly   657 H-------VNDWISQVIRIYEGVS------RVELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVF 708
            :       .|...|.|.|:..|..      |:|..:.|||:.::    .|.|...::.:.:|...
Zfish   673 YFYREEEDANHTYSVVTRVPVGFKGRLSCFRLEQSYKVGPLEVN----RETVFRTRTSLQNNRTL 733

  Fly   709 YTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLLNDRSQGGASLEDG 773
            :||:||.::|||.       ....:...|:.|:||:.....::|::.|:|.|::|:.|.|||..|
Zfish   734 FTDNNGYQMMKRT-------YKGYANNTVARNYYPMVRVAYMEDESSRVVFLSERAHGVASLSQG 791

  Fly   774 ALEMLIHRRHLFND---GGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTERKTEKELFLP 835
            .||:::||| |:|:   ..|....||::.     :.|..|:::|.|.....::.:::..:....|
Zfish   792 QLEVMLHRR-LWNNQEWNQGYNLTLNDSS-----VVRPVLWMMLGSPDSLSSIYQQEAVELQHRP 850

  Fly   836 FWKFFSKTGGVEITPSKSL--------PDFND--LPQSVHLLTLEF----FSEQ----------- 875
            ......:       |.|.|        |..:.  |||::|:.:|..    :|.:
Zfish   851 VVMAIDQ-------PQKLLNQRETFSGPSVHPVVLPQNLHMQSLSIPGWNYSPEHSSGGDEKSEV 908

  Fly   876 ---EILIRFEHFLDKSEGRVIS----FNIRDIFDSLGGLA-IRETTLDGNMPLSDMKRFKFHAQE 932
               .||:|..|..::.|..|:|    .|::::...:|.:: ::|.:|.|...:||::|:.:...|
Zfish   909 NFDRILLRITHLYEEGESPVLSQPTTINLKEVMQGIGKVSKVQECSLTGTWNISDLQRWNWKTDE 973

  Fly   933 SGTKPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFII 975
            :..|.....:|        .|..|    |.||:.|.:||||.|
Zfish   974 TMQKTDKSGFS--------GVTQD----FNVTISPKEIRTFFI 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	92/291 (32%)
		Alpha-mann_mid	359..434	CDD:214875	24/81 (30%)
		Glyco_hydro_38C	483..973	CDD:285047	128/563 (23%)
man2b2	XP_001337519.3	PLN02701	20..1002	CDD:178304	271/1057 (26%)
man2b2	XP_001337519.3	GH38-57_N_LamB_YdjC_SF	23..348	CDD:330225	108/337 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920