Protein Alignment LManIII and MAN2A2

DIOPT Version :9

• Sequence 1: NP_001285762.1
• Gene: LManIII / 34203
• FlyBaseID: FBgn0032066
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_001307906.1
• Gene: MAN2A2 / 4122
• HGNCID: 6825
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 1135
• Identity: 279/1135 - (24%)
• Similarity: 442/1135 - (38%)
• Gaps: 297/1135 - (26%)

  Fly    37 INIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRFIQVETGFFAKW 101
            :.:.:|||||:|.||:||.|:||...        .|:|.:::|::|.:|.||||:..|..|||||
Human   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   102 WEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLNDNFGVCGRPRVG 166
            |::.:..|:..|:.||..|:||...|.|.|.|||..:|.::|||...|.::|..|.|  ..||.|
Human   223 WDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLG--ATPRSG 285

  Fly   167 WQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVWDAS-ETLEEMDFFTGML- 229
            |.:|.||:|.....:..:.........|:....|........||.:|..: ::....|.|..|:
Human   286 WAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP 350

  Fly   230 YNHYSAP------PGFCFDSLCQDD-------------PIIDGKSYDNNVKSRVDDFLNYASNLA 275
            :..|..|      |..|    ||.|             .:......:.||..|....|:.....:
Human   351 FYSYDVPHTCGPDPKIC----CQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKS 411

  Fly   276 GYYRSNHIMVPMGDDFQYEN------AYMNYKNMDKLIKYVNER-----QASGSKYNIFYSTAGC 329
            ..:|||.::||:||||:|:.      .:.||:   :|..:.|.|     ||.       :.|...
Human   412 QLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQ---RLFDFFNSRPNLHVQAQ-------FGTLSD 466

  Fly   330 YLNSLHKSL--------QSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQL 386
            |.::|:|..        ..||..:.||..::.....:|||::||||..|..:|.....|:.|:.|
Human   467 YFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVL 531

  Fly   387 SVLA-------DLSGEEQHKDLDYL---RQIMAVMQHHDAITGTEKQEVSNDYD-RLL------- 433
            ..||       .|:|.....|...|   |:.:.:.|||||||||.|:.|..||. |||
Human   532 YSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLK 596

  Fly   434 -------YDAILGGANTARDALRVLTNQPNGEFQSCLKLNISECAFTKE-----NADDFMVTLYN 486
                   :..:||...|..       ..|...|.......:|..|..:.     ::....|.|:|
Human   597 QVIIHAAHYLVLGDKETYH-------FDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFN 654

  Fly   487 PLAHTSTQYVRVPVKEDSYQVTDEKGGLV----------ASELVPVPWEV--------------- 526
            ||.......|.:.|.....:|..|:|..:          |:|.||..::|
Human   655 PLEQERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQ 719

  Fly   527 LSLEFRNNDTQHELV------FKASVNKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVP 585
            |.|....:.|....|      .:.||::...:.::.||..|
Human   720 LQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGT------------------------ 760

  Fly   586 KRFKKVHSLKTDLETLDDQETIVQNSLIKLVIDNNTGRLKTVEMNGVSEDIDQTFGM----YKTA 646
                              .:..:.|..:::.....||.||::..  |.|:.:|...|    |.|.
Human   761 ------------------SDFALSNRYMQVWFSGLTGLLKSIRR--VDEEHEQQVDMQVLVYGTR 805

  Fly   647 ----RSCHYIFRQDADLE--LVEDAFDFTVYDGESVKEV---HQHVNEWISQVIRIYE--GVNRV 700
                :|..|:|..|.:.:  :.::.....|.:|....||   ::|::    |.:|:|.  ||..:
Human   806 TSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIH----QAVRLYNLPGVEGL 866

  Fly   701 EFEWLVGPVPIDDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGN 765
            ..: :...|.|.|.:.||:.....:.|.|.|:|:||.||.::..|..         |.:.|:..|
Human   867 SLD-ISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPRRY---------LKKLPLQAN 921

  Fly   766 YYPVTSRMALQDSSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAI---------- 820
            :||:.....:||:.||:.|...::.|.:||:||:||::|.||.:..|..|..:.:
Human   922 FYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRF 986

  Fly   821 ----------NEQQFGKGLIA--RGKLF---------------------------LYLNAIEDGA 846
                      :|..|...|.|  ||.:|                           :||||    .
Human   987 RLLLERRTVGSEPDFFSKLAAMFRGLIFHSSRSGNREVQDSHSTSYPSLLSHLTSMYLNA----P 1047

  Fly   847 TASERVAEKEIHLPFWKFFSKSNNIQSDVTKTLSDFNDLPQSVHLLTLEPYSKDEILLRLENFLD 911
            ..:..||..::..|..:.|...             .:.||...|||.|.....:      |:.|.
Human  1048 ALALPVARMQLPGPGLRSFHPL-------------ASSLPCDFHLLNLRTLQAE------EDTLP 1093

  Fly   912 QTEGNVVSFSIRQIFDDLGGLEIRE-----TTLDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSL 971
            ..|..::..  |:.||  .|||.:.     ||..|.:.|..:    ||  |.......|...|.|
Human  1094 SAETALILH--RKGFD--CGLEAKNLGFNCTTSQGKVALGSL----FH--GLDVVFLQPTSLTLL 1148

  Fly   972 HKPLAADKTQDASEFSVTLKPMQIRTFIIK 1001
            : |||:    .::...|.|:||:|.||.::
Human  1149 Y-PLAS----PSNSTDVYLEPMEIATFRLR 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	90/300 (30%)
		Alpha-mann_mid	358..433	CDD:286360	33/85 (39%)
		Glyco_hydro_38C	603..998	CDD:285047	109/463 (24%)
MAN2A2	NP_001307906.1	PLN02701	136..1174	CDD:178304	279/1135 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810