DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and alpha-Man-IIa

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	232/923 - (25%)
Similarity:	406/923 - (43%)	Gaps:	173/923 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRF 90
            |:.......:.:.:.:|||||:|.||::|.::||   :|:.:|     |....:..|..:...:|
  Fly   134 YDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYY---QHDTKH-----ILSNALRHLHDNPEMKF 190

  Fly    91 IQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLND 155
            |..|..:||:::.|..|.||..:|::|..|:|||..|.|.|.|||..::::|:.|...|..:|..
  Fly   191 IWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQ 255

  Fly   156 NFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVW-DASETL 219
            ...|  .|...|.||.||||.....:..:..|......|...:.|.:......||.:| ...:..
  Fly   256 FMNV--TPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNK 318

  Fly   220 EEMDFFTGMLYNHYSAPPGFCFD--SLCQDDPII----DGKSY-----------------DNNVK 261
            .:...||.|:       |.:.:|  ..|..||.:    |.|..                 |.||.
  Fly   319 GDTALFTHMM-------PFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVA 376

  Fly   262 SRVDDFLNYASNLAGYYRSNHIMVPMGDDFQY-ENAYMNYK--NMDKLIKYVNERQASGSKYNI- 322
            :|.|..::.....|..||:|.:::|:||||:: :|...:.:  |.::|.:::|    |.:.:|:
  Fly   377 ARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHIN----SQAHFNVQ 437

  Fly   323 -FYSTAGCYLNSLHKSLQS----FPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQV 382
             .:.|...|.:::|::.::    ||..:.||..::..:.::|:|::||||..||.:|...|.::.
  Fly   438 AQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRA 502

  Fly   383 AKQLSVLADLSG----EEQHKDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILGGANT 443
            |:.||......|    ||:   |:..|:.:::.||||.||||.|..|..||::.:.:|:......
  Fly   503 AEMLSAWHSWDGMARIEER---LEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMV 564

  Fly   444 ARDALRVLTNQPNGEFQSCLKLNISECAFTKENA-----------------DDFM----VTLYNP 487
            .:.::..|..:|     |....:.|...||.:::                 :|.:    |.::|.
  Fly   565 MQQSVYRLLTKP-----SIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNT 624

  Fly   488 LAHTSTQYVRVPVKEDSYQVTDEKGGLVASELVPV-PWE----VLSLEFRNNDTQHELVFKASVN 547
            |.|...|.|...|......|||.....|.:::.|| .|.    ..::..:.:.|::.::|||.|.
  Fly   625 LPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVP 689

  Fly   548 K--IATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKKVHSLKTDLETLDDQETIVQN 610
            .  :|||.:...|...|     :|....::...::...:|     :.....|::..|.:|
  Fly   690 PMGLATYVLTISDSKPE-----HTSYASNLLLRKNPTSLP-----LGQYPEDVKFGDPRE----- 739

  Fly   611 SLIKLVIDN-------NTGRLKTVEMNGVSEDIDQTFGMYKTA------RSCHYIFRQDADLELV 662
              |.|.:.|       ..|.||::::...|..:...|...|..      ||..|:|..:.....|
  Fly   740 --ISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPV 802

  Fly   663 E----------DAFDFTVYDG-ESVKEVHQHVNEWISQVIRIYEGVNRVEFEWLVGPVPIDDELG 716
            |          ...:.:|..| .||  |||.:....:..||     |.|:    :|.:.     .
  Fly   803 ELGQPVVLVTKGKLESSVSVGLPSV--VHQTIMRGGAPEIR-----NLVD----IGSLD-----N 851

  Fly   717 KEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQDSSKR 781
            .|||...::.|.||.:||||.||.:.::|.:         |.:.|:..||||:.|.|.::|::.|
  Fly   852 TEIVMRLETHIDSGDIFYTDLNGLQFIKRRR---------LDKLPLQANYYPIPSGMFIEDANTR 907

  Fly   782 MVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGKGLI-ARGKLFLYLNAIEDG 845
            :.||..:..||:||..|.||:|..|| :.:|        :|:..|:|:: .:..|.:|...:|
  Fly   908 LTLLTGQPLGGSSLASGELEIMQDRR-LASD--------DERGLGQGVLDNKPVLHIYRLVLE-- 961

  Fly   846 ATASERVAEKEIH 858
             ..:..|...|:|
  Fly   962 -KVNNCVRPSELH 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	82/300 (27%)
		Alpha-mann_mid	358..433	CDD:286360	30/78 (38%)
		Glyco_hydro_38C	603..998	CDD:285047	73/281 (26%)
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	94/359 (26%)
		Alpha-mann_mid	478..554	CDD:214875	30/78 (38%)
		Glyco_hydro_38C	744..1103	CDD:285047	70/267 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450138
Domainoid	1	1.000	50	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I462
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.790