DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and Man2b2

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001128443.2	Gene:	Man2b2 / 360955	RGDID:	1308840	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	1110	Identity:	279/1110 - (25%)
Similarity:	444/1110 - (40%)	Gaps:	282/1110 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 INIHLVPHSHDDLGWLKTVDQ---YYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRFIQVETGFF 98
            |...:|||||.|:||:.||.:   .|..|           ::.|||.||.:..:||||.||..||
  Rat    27 IRAFVVPHSHMDVGWVYTVQESMRAYAAN-----------VYTTVVEELVRGRQRRFIAVEQEFF 80

  Fly    99 AKWWED-QSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLNDNFGVCGR 162
            ..||:. .||.:|:.|:.|::||||||..|...|:|||..:....|.|...|..||.:.||:  |
  Rat    81 RLWWDGVASEQQKQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--R 143

  Fly   163 PRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVWDASETLEE------ 221
            |:..|.:|.||.|....::||...|:....:|:|.:.|:...:..||:.||..|.:|.|
  Rat   144 PQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVWHGSPSLSEQQEIYT 208

  Fly   222 --MDFFTGMLYNH--YSAPPGFCFDSLCQ-DDPIIDGKSYDNNVKSRVDDFLNYASNL------- 274
              ||.::....:|  :|...||.::.:.. .:|..||...:.:....||:...||..|
  Rat   209 HVMDLYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTVDNIHLYAEALVANVKQR 273

  Fly   275 AGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYSTAGCYLNSLHKSLQ 339
            |.::|:.|::.|.|.|.|:.||.:.:.|||.|::|:|.|.|... .::.|:|...|..:||..
  Rat   274 AAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNRSAQFG-ISVQYATLNDYFQALHDF-- 335

  Fly   340 SFPNKT------QDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSV-------LAD 391
               |.|      .||||:|.|.:..||||||||.|.|...|..:.:|...:.:..       ...
  Rat   336 ---NVTWDIRDHHDFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGESMFTRYMWPHPRGT 397

  Fly   392 LSGEEQHKDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILGGANTARDALRVLTNQPN 456
            |......:.|..||..::.:||||||||||..:|.|.|   :....:|.....:....:..::|.
  Rat   398 LDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMY---MEHLSMGMRGVHKLMASIALDRPP 459

  Fly   457 GEFQSCLKLNISECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELV- 520
            |             :.|......:..::|||||...|..:.:.|...|..||||.|..|::::.
  Rat   460 G-------------SGTDTRPVGYSASVYNPLAWKITTIITLTVAFPSVSVTDELGRPVSAQIQN 511

  Fly   521 ----PVPWEVL------SLEFRNNDTQHELVFKASVNKIAT------YFIKKIDKTTEVDITVNT 569
                |..:::|      .|.:|:...:.....:|...::.|      .|.:|:          ..
  Rat   512 STKDPSAYDLLILTTIPGLSYRHYKVRRTRGDQAGTRELVTPRANTLKFSRKL----------RN 566

  Fly   570 QTEQSVNEEESNVKVPKRFKKVHSLKTDLETLDDQETIVQNSLIKLVIDNNTGRLKTVE--MNGV 632
            ||.|     |..:.||                      |.|....|:.|.:|..|.:::  .:..
  Rat   567 QTSQ-----EGKLLVP----------------------VMNDCYTLLFDQDTNMLHSIQDRQSNR 604

  Fly   633 SEDIDQTFGMYKT-------ARSCHYIFRQDADLELVEDAFDFTVYDGESVKEVHQHVNEWISQV 690
            :..:.|.|..|:.       ..|.:|:|..:...|...:|....:..|....:|.|:....|:..
  Rat   605 TVHMTQEFLEYRANGDVKQGPISDNYLFASNDTAEPSWEAVGMEMVVGTLATDVRQYFYRNITDQ 669

  Fly   691 IRIYE-------------G---VNRVEFEWLVGPVPIDDELGKEIVTIFKSGISSGGVFYTDSNG 739
            ..||.             |   ..|:|.::.|||:    :|.:|.:....|.::|..|.|:|:||
  Rat   670 GYIYSIHTRLAHVHPSLAGELLCRRIEQQYQVGPL----DLNREAILRTSSDLNSQQVLYSDNNG 730

  Fly   740 REMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQDSSKRMVLLNDRSQGGASLEDGRLEMML 804
            .:|.||....       ....|:..||||:.....::|...|:|||.:|..|.:|.|:|::|:||
  Rat   731 YQMQRRPYKA-------FKSNPIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQVEVML 788

  Fly   805 HRRHIFADGSGAAEAINEQQFGKGLIARGKLFLYLNAIED---GATASERVAEKEIHLPFWKFFS 866
            |||                             |:.|.:.|   ..|.::   ...:|...|....
  Rat   789 HRR-----------------------------LWNNLVWDLNYNLTLND---TSVVHPVLWLLLG 821

  Fly   867 KSNNI-----QSDVT---------KTLSDFND-------------LPQSVHLLTLE----PYSKD 900
            ..:..     :|.|.         |.|:|..:             ||.|:||..|.    .||::
  Rat   822 PKSTTTALRPRSGVALQHRPVVLLKELTDEEETAIHRPHHPWPVTLPPSLHLQVLSLPGWQYSRN 886

  Fly   901 ---------------------EILLRLENFLDQTEGNVVS----FSIRQIFDDLGG-LEIRETTL 939
                                 .:||||.:..:..|..|:|    ..::.....||. :.:.|.:|
  Rat   887 HAQHLKNLQRGHPEKPQVNLQRVLLRLHHLYEAGEDPVLSRPATVDLKIALRGLGSVVAVEERSL 951

  Fly   940 DGNLPLSDMKR---------LKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQI 995
            .|...:..::|         ||.|                   |.:..::...|  .:|:.|.:|
  Rat   952 TGTWDVQTLQRWHWRTKIGQLKGH-------------------PTSPPRSPGGS--IITVYPKEI 995

  Fly   996 RTFII 1000
            |||.|
  Rat   996 RTFFI 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	99/295 (34%)
		Alpha-mann_mid	358..433	CDD:286360	29/81 (36%)
		Glyco_hydro_38C	603..998	CDD:285047	100/488 (20%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	235/876 (27%)
Man2b2	NP_001128443.2	GH38N_AMII_Epman_like	27..352	CDD:212122	113/343 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020