DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and LManII

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster

Alignment Length:	1079	Identity:	484/1079 - (44%)
Similarity:	657/1079 - (60%)	Gaps:	143/1079 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRF 90
            |:||..||.||:|:|||.|:|||:||||||||||||::..||.||||||.|:||..|.:|..:||
  Fly    36 YQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRF 100

  Fly    91 IQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLND 155
            |.||:.||.|||::|....::.||.||.:|||||.||||||||||..:||||||||:.||:.|||
  Fly   101 IYVESAFFFKWWKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLND 165

  Fly   156 NFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVWDASETL- 219
            .||.|||||||||||.||||||.|||||||.|||.||.|:|..||::|:.....||:|..|..|
  Fly   166 TFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLG 230

  Fly   220 EEMDFFTGMLYNHYSAPPGFCFDSLCQDDPIIDGK-SYDNNVKSRVDDFLNYASNLAGYYRSNHI 283
            ||.|.|:|.|||:|.||.|||||.||.|.|||||| |.|||||.|:|.||::|...:.|||:|:|
  Fly   231 EEADLFSGALYNNYQAPDGFCFDILCNDAPIIDGKHSPDNNVKERIDTFLDFAKTQSQYYRTNNI 295

  Fly   284 MVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYSTAGCYLNSLHKSLQSFPNKTQDF 348
            :|.||.||.|:.|.:.|||:||||:|.|||||:||..|:.|||..|||.|||.:..::|.|:.||
  Fly   296 IVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLHDAGITWPTKSDDF 360

  Fly   349 LPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSVLADLSGEEQHKDLDYLRQIMAVMQH 413
            .|::.:..::|||:||||||.|||||||||.|||.||||.||....||....|.::|:.:.:|||
  Fly   361 FPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAPKKPEEFDPHLTFMRETLGIMQH 425

  Fly   414 HDAITGTEKQEVSNDYDRLLYDAILGGANTARDALRVLTNQPNG-----------EFQSCLKLNI 467
            |||||||||::|:.||.:.:..|......|.|:||..||.|...           ||::|..|||
  Fly   426 HDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNI 490

  Fly   468 SECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELVPVPWEVLSLEFR 532
            :.|..::.| |.|.:|||||||||..:|||:||...:|::.|.||..:.|:.||:|..::.::.|
  Fly   491 TSCPVSEAN-DRFALTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHR 554

  Fly   533 NNDTQHELVFKASVNKIA----TYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKKVHS 593
            |:..::|:||.|: |..|    ||:::|:|.|..     ||:::          .:|||...|
  Fly   555 NSTAKYEIVFLAT-NIPALGYRTYYVEKLDSTEG-----NTRSK----------ALPKRTSSV-- 601

  Fly   594 LKTDLETLDDQETIVQNSLIKLVIDNNTGRLKTVEMNGVSEDIDQTFGMYKTA----------RS 648
                        |::.||.|:|..|.| |.|..|..:|::..:.|.|..|:.|          .|
  Fly   602 ------------TVIGNSHIQLGFDTN-GFLSEVTADGLTRLVSQEFLFYEGAVGNNAEFLNRSS 653

  Fly   649 CHYIFRQDAD-LELVEDAFDFTVYDGESVKEVHQHVNEWISQVIRIYEGVNRVEFEWLVGPVPID 712
            ..||||.:.: :....|..:..||.|:.|.||||..|:|||||:|:|...:..||||||||:|||
  Fly   654 GAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVGPIPID 718

  Fly   713 DELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQD 777
            |.:|||::|.|.|.|:|.|:|.||||||||::|:.:.|:.:|..::| .|:|||||:|:::.::|
  Fly   719 DGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINE-AVAGNYYPITTKIDVED 782

  Fly   778 SSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGKGLIARGKLFLYLNAI 842
            .:.||.:|.||:|||:||:||.||:|:|||.:..|..|..||:||.::|.|||||||..|:....
  Fly   783 DTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGKS 847

  Fly   843 EDGATAS----ERVAEKEIHLPFWKFFSKSNNIQSDVTKTLSDFND--------LPQSVHLLTLE 895
            .|....|    ||:.:.|..||.|||||...:..:|..:|.  |.:        ||:.|||||||
  Fly   848 TDREGVSLKGIERLTQLEKLLPTWKFFSNMEDYSADEWQTA--FTNIFSGISLVLPKPVHLLTLE 910

  Fly   896 PYSKDEILLRLENFLDQTE----GNVVSFSIRQIFD--DLGGLEIRETTLDGNLPLSDMKRLKFH 954
            |:.::::|:|.|:.::..|    ...|.|:::.:..  |:.|  |||||||||..|.:.:||:|.
  Fly   911 PWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEG--IRETTLDGNAWLDESRRLQFA 973

  Fly   955 HDG-----------SGPSHSVPEYFTSLHKPLAADKTQDAS------------------------ 984
            .|.           |.|:.||  :..|..||:...|..|.:
  Fly   974 PDPEEAAFNTYATFSQPAESV--HLLSAEKPMLGVKYADEALPAGQLGAESNRIRRETETRQEKK 1036

  Fly   985 -----------------------EFSVTLKPMQIRTFII 1000
                                   |:.:.|.||:|||||:
  Fly  1037 DEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTFIV 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	173/275 (63%)
		Alpha-mann_mid	358..433	CDD:286360	46/74 (62%)
		Glyco_hydro_38C	603..998	CDD:285047	174/481 (36%)
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	173/275 (63%)
		Alpha-mann_mid	370..445	CDD:214875	46/74 (62%)
		Glyco_hydro_38C	502..957	CDD:285047	190/490 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450125
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	12	11.750