DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and LManV

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001285763.1	Gene:	LManV / 34205	FlyBaseID:	FBgn0032068	Length:	982	Species:	Drosophila melanogaster

Alignment Length:	1006	Identity:	681/1006 - (67%)
Similarity:	820/1006 - (81%)	Gaps:	30/1006 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKNLAILL--ALFASYIVQSEAVC-YESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHN 65
            :|.|.|:|  |..|.....::||| ||||.||||||||||||||||||:||||||||||||:::|
  Fly     1 MKFLGIVLCVAFLALQAKSAQAVCGYESCHETKSNMINIHLVPHSHDDVGWLKTVDQYYYGHRNN 65

  Fly    66 IQHAGVQYIFDTVVAELSKDSRRRFIQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWS 130
            |||||||||.|||::||.|:..||||||||.||:|||.:||||.:.:||.|||||||:|..||||
  Fly    66 IQHAGVQYIIDTVISELIKNPDRRFIQVETSFFSKWWNEQSETMRAVVKMLVNEGRLQFINGAWS 130

  Fly   131 MNDEAAVNYQSVIDQFAVGLKFLNDNFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARM 195
            ||||||||||||||||.||||||:|.||||||||||||||.|||||||||::|||.|||:||:||
  Fly   131 MNDEAAVNYQSVIDQFTVGLKFLDDTFGVCGRPRVGWQIDPFGHSREQASIYAQMGFDGEFFSRM 195

  Fly   196 DQNDKNKRVDNLGLEMVWDASETLEEMDFFTGMLYNHYSAPPGFCFDSLCQDDPIIDGKSYDNNV 260
            |.|||.:|:::|.|||:|||||:|.::..|||:||..|...||||||..|.||||||..||||||
  Fly   196 DHNDKGRRMNDLALEMIWDASESLSQVKLFTGLLYTFYWDTPGFCFDVHCSDDPIIDSDSYDNNV 260

  Fly   261 KSRVDDFLNYASNLAGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYS 325
            |||||||:.||:.:|..:|:||||:|||.|||||:|.:||||||||||||||||:|||||||.||
  Fly   261 KSRVDDFIAYAAQVAEKFRTNHIMIPMGGDFQYEDAEVNYKNMDKLIKYVNERQSSGSKYNIIYS 325

  Fly   326 TAGCYLNSLHKSLQSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSVLA 390
            |..|||||:|||:||:||||.||.|:..:..|||||::||||||||||||||||||||||||..|
  Fly   326 TPTCYLNSVHKSVQSYPNKTLDFFPYGSDTNSFWTGYYTSRPTQKRFERDGNHILQVAKQLSAFA 390

  Fly   391 DLSGEEQHKDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILGGANTARDALRVLTNQP 455
            :||..:|.:||:|||:||.||||||||||||||.||:||||:|||||:||..||.||||.|||.|
  Fly   391 ELSSTQQKEDLEYLREIMGVMQHHDAITGTEKQHVSDDYDRILYDAIVGGVKTAGDALRKLTNLP 455

  Fly   456 NGEFQSCLKLNISECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELV 520
            ||||:|||:||||||||||:.||:.:|||||.||||:.||||||||.::||||||||.:||||:|
  Fly   456 NGEFESCLQLNISECAFTKDGADNVVVTLYNALAHTTKQYVRVPVKNENYQVTDEKGRVVASEIV 520

  Fly   521 PVPWEVLSLEFRNNDTQHELVFKASVNKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESN-VKV 584
            |||.|||:||||::||||||||||||:|||.|:|||:|                 ::|.|| |:|
  Fly   521 PVPAEVLALEFRDSDTQHELVFKASVDKIANYYIKKVD-----------------SKESSNGVRV 568

  Fly   585 PKRFKKVHSLKTDLETLDDQETIVQNSLIKLVIDNNTGRLKTVEMNGVSEDIDQTFGMYKTARSC 649
                  :...|.:.||.||:|||||.||||||:||.||.||.||||||||:|:|::|:|:|..|.
  Fly   569 ------ISQPKANAETYDDEETIVQTSLIKLVLDNKTGLLKRVEMNGVSENIEQSYGLYRTYDSG 627

  Fly   650 HYIFRQ--DADLELVEDAFDFTVYDGESVKEVHQHVNEWISQVIRIYEGVNRVEFEWLVGPVPID 712
            .|:|||  ..|..:.||..:||||||..||||||..:|:|||||||.|....|||||||||:|::
  Fly   628 AYVFRQYNQGDFVIQEDGVEFTVYDGALVKEVHQRFSEYISQVIRISEDKPYVEFEWLVGPIPVE 692

  Fly   713 DELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQD 777
            :|.|.|:||||.|.|:|.|||||||||||::||||||||||:|:|:.||.||||||:|||:||||
  Fly   693 EEFGTEVVTIFSSEIASNGVFYTDSNGRELIRREKDKREDFTPELAVQPTSGNYYPITSRIALQD 757

  Fly   778 SSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGKGLIARGKLFLYLNAI 842
            |:||:.:||||:|||.|::||::|:|||||.:..||.|..||:||:::|:.||||||:||.|||
  Fly   758 SNKRLAILNDRAQGGTSMKDGQIELMLHRRLVRDDGYGVGEALNEEKYGQPLIARGKVFLILNA- 821

  Fly   843 EDGATASERVAEKEIHLPFWKFFSKSNNIQSDVTKTLSDFNDLPQSVHLLTLEPYSKDEILLRLE 907
            .|.:|::||.||||.|||.||||||:....:...|::..|:|.|:|||||||||::.||||||:|
  Fly   822 ADESTSAEREAEKEFHLPLWKFFSKNTGSTTAAAKSVPSFDDFPKSVHLLTLEPFNDDEILLRVE 886

  Fly   908 NFLDQTEGNVVSFSIRQIFDDLGGLEIRETTLDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLH 972
            ||.|..||.||||:||.|||.|.|:|||||||||||||||||:.|||.:|||...|.|||:||.|
  Fly   887 NFKDHIEGKVVSFNIRPIFDYLNGVEIRETTLDGNLPLSDMKQFKFHAEGSGIRGSEPEYYTSSH 951

  Fly   973 KPLAADKTQDASEFSVTLKPMQIRTFIIKKE 1003
            |||:|::||||:||:|||.||||||||||.|
  Fly   952 KPLSANQTQDAAEFAVTLYPMQIRTFIIKHE 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	202/273 (74%)
		Alpha-mann_mid	358..433	CDD:286360	59/74 (80%)
		Glyco_hydro_38C	603..998	CDD:285047	257/396 (65%)
LManV	NP_001285763.1	GH38N_AMII_LAM_like	37..311	CDD:212121	202/273 (74%)
		Alpha-mann_mid	358..433	CDD:286360	59/74 (80%)
		Glyco_hydro_38C	481..977	CDD:285047	326/519 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450119
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	13	12.760