DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and LManIV

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	998	Identity:	693/998 - (69%)
Similarity:	823/998 - (82%)	Gaps:	30/998 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LAILLALFASYIVQSEAVC-YESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAG 70
            |:|||.|||.   |||||| ||||||||:||:|||||||||:|:||||||||.|||.|:.|.|||
  Fly    10 LSILLVLFAK---QSEAVCGYESCPETKANMVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAG 71

  Fly    71 VQYIFDTVVAELSKDSRRRFIQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEA 135
            ||||.|:||::|.:|.:||||||||.||||||..|||:.||:|..||||||.|||||||||||||
  Fly    72 VQYILDSVVSQLLQDPKRRFIQVETAFFAKWWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEA 136

  Fly   136 AVNYQSVIDQFAVGLKFLNDNFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDK 200
            .||||.|||||.|||||||:.||.|||||||||||.||||||||::||.|.:|||||:|||.|||
  Fly   137 NVNYQGVIDQFTVGLKFLNETFGSCGRPRVGWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDK 201

  Fly   201 NKRVDNLGLEMVWDASETLEEMDFFTGMLYNHYSAPPGFCFDSLCQDDPIIDGKSYDNNVKSRVD 265
            :.|:::|.:||:|||||::..:..|:|||||.||..||||||.||.|.|||||.|.:||||.|||
  Fly   202 DTRMNDLTMEMIWDASESMSGVSLFSGMLYNFYSDTPGFCFDILCTDQPIIDGDSEENNVKQRVD 266

  Fly   266 DFLNYASNLAGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYSTAGCY 330
            ||::||.|::..|.:||||||||.|||||:|.:|||||||||||:||||||||||||||||..||
  Fly   267 DFISYAKNVSEVYITNHIMVPMGGDFQYEDAKVNYKNMDKLIKYINERQASGSKYNIFYSTPSCY 331

  Fly   331 LNSLHKSLQSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSVLADLSGE 395
            |||||:||:|:|||||||.|::||..||||||||||||||||||||||:|||||||||||:|:.|
  Fly   332 LNSLHQSLESWPNKTQDFFPYAHEKNSFWTGFFTSRPTQKRFERDGNHMLQVAKQLSVLANLTSE 396

  Fly   396 EQHKDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILGGANTARDALRVLTNQPNGEFQ 460
            |...|||||||:|.||||||||||||||.||:||||::|:||:|.:|.||||||:|||.|.|||:
  Fly   397 EHKIDLDYLRQVMGVMQHHDAITGTEKQAVSDDYDRMMYEAIVGASNNARDALRLLTNMPYGEFE 461

  Fly   461 SCLKLNISECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELVPVPWE 525
            |||:||||||||||:.||:.:|||||||||:||||||:||||::||||||||..|.||:|||||:
  Fly   462 SCLRLNISECAFTKDGADNVLVTLYNPLAHSSTQYVRIPVKEENYQVTDEKGRTVPSEVVPVPWQ 526

  Fly   526 VLSLEFRNNDTQHELVFKASVNKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKK 590
            ||:||:|:|||||||||||:|||:::|.|||::.:     .|...:.:.:|..|.|
  Fly   527 VLALEYRSNDTQHELVFKATVNKVSSYSIKKVESS-----EVKHSSIKKINPREDN--------- 577

  Fly   591 VHSLKTDLETLDDQETIVQNSLIKLVIDNNTGRLKTVEMNGVSEDIDQTFGMYKTARSCHYIFRQ 655
                        :.||:|:||::|||:||:|||||:||||||||.|.|.||:||:..||.|.|||
  Fly   578 ------------NSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIVQNFGVYKSHTSCAYTFRQ 630

  Fly   656 DADLELVEDAFDFTVYDGESVKEVHQHVNEWISQVIRIYEGVNRVEFEWLVGPVPIDDELGKEIV 720
            |.|:||.|:.|:||||:|..|||||||||:||||||||||||:|||.||:|||:||||:||.|.|
  Fly   631 DGDIELFENDFEFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRVELEWMVGPIPIDDKLGSEFV 695

  Fly   721 TIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQDSSKRMVLL 785
            |.|||.|||.|||||||||||:|:|.|||||||..|||.||||||:||||||:||||.:||:|||
  Fly   696 TNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGNFYPVTSRIALQDDTKRLVLL 760

  Fly   786 NDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGKGLIARGKLFLYLNAIEDGATASE 850
            |||||||||||||.|||::||||:|.||.|..||:||.|:||||||||||:|.|::..||.|.:|
  Fly   761 NDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLIARGKLYLILDSATDGDTVTE 825

  Fly   851 RVAEKEIHLPFWKFFSKSNNIQSDVTKTLSDFNDLPQSVHLLTLEPYSKDEILLRLENFLDQTEG 915
            |..|||:.|||||||||:..::...:|:|.|||||||||||||||.:|:.|||:|.|:|||::||
  Fly   826 RKTEKELFLPFWKFFSKTGGVEITPSKSLPDFNDLPQSVHLLTLEFFSEQEILIRFEHFLDKSEG 890

  Fly   916 NVVSFSIRQIFDDLGGLEIRETTLDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKT 980
            .|:||:||.|||.||||.|||||||||:|||||||.|||...||...|..||.|:.||||.|.|:
  Fly   891 RVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGTKPSSVEYSTAQHKPLEAVKS 955

  Fly   981 QDASEFSVTLKPMQIRTFIIKKE 1003
            .:||.|:|||.||||||||||.|
  Fly   956 DEASLFAVTLYPMQIRTFIIKTE 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	195/273 (71%)
		Alpha-mann_mid	358..433	CDD:286360	63/74 (85%)
		Glyco_hydro_38C	603..998	CDD:285047	274/394 (70%)
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	195/272 (72%)
		Alpha-mann_mid	359..434	CDD:214875	63/74 (85%)
		Glyco_hydro_38C	483..973	CDD:285047	336/515 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450115
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	13	12.760