DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and Man2a1

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_037111.2	Gene:	Man2a1 / 25478	RGDID:	3038	Length:	1148	Species:	Rattus norvegicus

Alignment Length:	1098	Identity:	270/1098 - (24%)
Similarity:	455/1098 - (41%)	Gaps:	228/1098 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRF 90
            ||: .|.....:.:.:|||||:|.|||||.:.|:...        .||||:.:|.:|.:||.|:|
  Rat   155 YEA-DEWDREPLQVFVVPHSHNDPGWLKTFNDYFRDK--------TQYIFNNMVLKLKEDSSRKF 210

  Fly    91 IQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLND 155
            |..|..:.||||:.....||:.||:|:..|:||...|.|.|.|||..:|.::|||...|.::|..
  Rat   211 IWSEISYLAKWWDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEK 275

  Fly   156 NFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMV----WDAS 216
            |.||  :||.||.||.||||.....:..:..|......|:..:.|........||..    ||..
  Rat   276 NLGV--KPRSGWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLG 338

  Fly   217 ETLE----EMDFFTGMLYN--HYSAP-PGFCFDSLCQ-DDPIIDGKSY------------DNNVK 261
            .|.:    .|.|::   |:  |...| |..|    || |...:.|..|            ..||:
  Rat   339 STTDILCHMMPFYS---YDIPHTCGPDPKIC----CQFDFKRLPGGRYGCPWGVPPEAISPGNVQ 396

  Fly   262 SRVDDFLNYASNLAGYYRSNHIMVPMGDDF---QYENAYMNYKNMDKLIKYVNERQASGSKYNIF 323
            ||....|:.....:..:|:..::.|:||||   :|....:.|:|.::|..|:|.:  ...|..|.
  Rat   397 SRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQ--PHLKVKIQ 459

  Fly   324 YSTAGCYLNSLHKSLQS--------FPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHIL 380
            :.|...|.::|.||:.:        ||..:.||..::.....:|:|:|||||..||.:|.....|
  Rat   460 FGTLSDYFDALEKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRL 524

  Fly   381 QVAKQLSVLADLSGEEQHKDLDYL-----------RQIMAVMQHHDAITGTEKQEVSNDYDRLLY 434
            :.|:.|..|| |...:::|...:|           |:.:.:.|||||||||.|..|..||...|:
  Rat   525 RTAEILYHLA-LKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLF 588

  Fly   435 DAILGGANTARDALRVLTNQPNGEFQS-----CLKLNISECAFTKENADDFM------------- 481
            .::........|:..:|..:....:||     .|:::      ||:::.|.:
  Rat   589 QSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMD------TKQSSQDSLPKKNIIQLSAQEP 647

  Fly   482 --VTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELVPVPWEVLSLEFRNNDTQHELVF-- 542
              :.:|||........|.|.|...:.:|..:.|..|..::..| |:.:.   ..:...:|:.|
  Rat   648 RYLVVYNPFEQERHSVVSVRVNSATVKVLSDLGKAVEVQVSAV-WKDMR---TTSQAAYEVAFLA 708

  Fly   543 ---------------KASVNKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKKVH 592
                           ::|.:.:|.||:...|                 .:.||.:...|..
  Rat   709 HLPPLGLKVYKILESQSSSSHLADYFLYNND-----------------GQAESGIFHMKNM---- 752

  Fly   593 SLKTDLETLDDQETI-VQNSLIKLVIDNNTGRLKTV--EMNGVSEDIDQTFGMYKTA----RSCH 650
                    :|..:.| ::||.:.|..| .:|.::.|  :.:...:::...|..|.|.    :|..
  Rat   753 --------VDSGDAITIENSFLTLGFD-RSGLMEKVRRKEDNKQQELKVQFLWYGTTNKRDKSGA 808

  Fly   651 YIFRQDADLE-LVEDAFDFT-VYDGESVKEVHQHVNEWISQVIRIY--EGVNRVEFEWLVGPVPI 711
            |:|..|...: .|.....|. |..|....:|...: |.::..:|:|  :|:.....| :...|.|
  Rat   809 YLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFL-EHVTHKVRLYHIQGIEGQSME-VSNIVDI 871

  Fly   712 DDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQ 776
            .....:|||....|.|::...:|||.||.::..|.         .:::.|:..|.||:::...:|
  Rat   872 RSVHNREIVMRISSKINNQNRYYTDLNGYQIQPRR---------TMAKLPLQANVYPMSTMAYIQ 927

  Fly   777 DSSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGKGLIARGKLFLYLNA 841
            |::.|:.||:.:|.|.:|:..|::|:.:.||.:..|..|..:.:::.:.      ...||..|..
  Rat   928 DAAHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKI------TANLFRILLE 986

  Fly   842 IEDGATASE-------------RVAEKEIHLPFWKFFSKSNNIQSDVTKTLSDF----NDLPQSV 889
            ..:|....|             .:....::.||.... .|..:.|...:.||:|    :.||..:
  Rat   987 KRNGMNMEEDKKSPVSYPSLLSHMTSAFLNHPFLPMV-LSGQLPSPAIELLSEFRLLQSSLPCDI 1050

  Fly   890 HLLTL--------EPYSKDEILLRLENFLDQTEGNVVSFSIRQIFD---DLGGLEIRETTLDGNL 943
            ||:.|        :.|| ||..|.|.               |::||   ....:.:..:|..|.:
  Rat  1051 HLVNLRTIQSKVGKGYS-DEAALILH---------------RKVFDCQLSSRAMGLPCSTTQGKM 1099

  Fly   944 PLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQIRTFIIK 1001
            .:..:      .:.......:|...:.:|.|..|..|.:     |:|.||:|.|..|:
  Rat  1100 SIPKL------FNNFAVESFIPSSLSLMHSPPDAQNTSE-----VSLSPMEISTSRIR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	97/300 (32%)
		Alpha-mann_mid	358..433	CDD:286360	32/85 (38%)
		Glyco_hydro_38C	603..998	CDD:285047	93/433 (21%)
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	270/1098 (25%)
		GH38N_Man2A1	164..507	CDD:212131	111/361 (31%)
		Alpha-mann_mid	502..587	CDD:214875	32/85 (38%)
		Glyco_hydro_38C	733..1142	CDD:285047	100/483 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1148		11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810