Protein Alignment LManIII and Man2b2

DIOPT Version :10

• Sequence 1: NP_609250.2
• Gene: LManIII / 34203
• FlyBaseID: FBgn0032066
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_032576.2
• Gene: Man2b2 / 17160
• MGIID: 1195262
• Length: 1018
• Species: Mus musculus
• Alignment Length: 1121
• Identity: 289/1121 - (25%)
• Similarity: 457/1121 - (40%)
• Gaps: 288/1121 - (25%)

  Fly    37 INIHLVPHSHDDLGWLKTVDQ---YYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRFIQVETGFF 98
            |...:|||||.|:||:.||.:   .|..|           ::.||||||.:..:||||.||..||
Mouse    27 IRAFVVPHSHMDVGWVFTVQESMRAYAAN-----------VYTTVVAELVRGGQRRFIAVEQEFF 80

  Fly    99 AKWWED-QSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLNDNFGVCGR 162
            ..||:. .||.:|:.|:.|::||||||..|...|:|||..:....|.|...|..||.:.||:  |
Mouse    81 RLWWDGVASEQQKQQVRQLLHEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--R 143

  Fly   163 PRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVWDASETLE-EMDFFT 226
            |:..|.:|.||.|....::||...|:....:|:|.:.|:...:...|:.||..|.:|. :.:.||
Mouse   144 PQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQMLQFVWHGSPSLSGQQEIFT 208

  Fly   227 GMLYNHYS--AP--------PGFCFDSLCQ-DDPIIDGKSYDN-------------------NVK 261
            .:: :|||  .|        .||.::.:.. .:|..|| .|.|                   |||
Mouse   209 HVM-DHYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDG-VYPNMSEPVTGANIHLYAEALVANVK 271

  Fly   262 SRVDDFLNYASNLAGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYST 326
            .|           |.::|:.|::.|.|.|.|:.||.:.:.|||.|:.|:|:|.|... .::.|:|
Mouse   272 QR-----------AAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLDYINQRTAQFG-ISVQYAT 324

  Fly   327 AGCYLNSLHKSLQSFPNKT------QDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQ 385
            ...|..:||.:     |.|      |||||:|.|....||||:|||.|.|...|..:.:|...:.
Mouse   325 LNDYFQALHAT-----NMTWGIRDHQDFLPYSSEPLQAWTGFYTSRSTLKGLARQASALLYAGES 384

  Fly   386 L---SVLADLSGEEQH----KDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILG---- 439
            :   .:..|.||....    :.|..||..::.:||||||||||..:|.|.|...|...:||
Mouse   385 MFTRYMWPDPSGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYTEHLRMGMLGVRKL 449

  Fly   440 ------------GANTARDAL-----RVLT--NQPNGEFQSCLKLNISECAFTKENADDFMVTLY 485
                        |....:|.:     .||:  .:|.|                      :..::|
Mouse   450 MVSIALGGPPGSGTGAPKDIMGPQVTPVLSVDTRPVG----------------------YSASVY 492

  Fly   486 NPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELV-----PVPWEVL------SLEFRNNDTQHE 539
            ||||...|..:.:.|...:..||||.|..|::::.     |..:::|      .|.:|:....|.
Mouse   493 NPLAWKITTIITLTVAFPNVSVTDELGHPVSTQIQNSTKDPSAYDLLILTTIPGLNYRHYQVMHA 557

  Fly   540 LVFKASVNKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKKVHSLKTDLETLDDQ 604
            ...:|...::    :.....|.:..:.:..|..|     |....||
Mouse   558 RGDQAGTREL----VAPRANTLKFSLKLRNQPSQ-----EGKRLVP------------------- 594

  Fly   605 ETIVQNSLIKLVIDNNTGRL---------KTVEMNGVSEDIDQTFGMYKTARSCHYIFRQDADLE 660
               |.|....|:.|.:|..|         :||.|.....:....:.:.:...|.:|:|..:...|
Mouse   595 ---VMNDCYILLFDQDTNMLHSIQDRQSNRTVRMTQEFLEYQANWDVKQGPISDNYLFAPNNTAE 656

  Fly   661 LVEDAFDFTVYDGESVKEVHQHVNEWISQVIRIYE-----------G---VNRVEFEWLVGPVPI 711
            ...:|....:..|..|.::.|:...:|:....||.           |   ..|:|.::.|||:
Mouse   657 PSWEAVGMEMVAGTLVTDIRQYFYRYITDQEYIYSIHTRLAHPSLAGELLCQRIEQQYRVGPL-- 719

  Fly   712 DDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQ 776
              :|.:|.:....|.::|..|.|:|:||.:|.||....       ....|:..||||:.....::
Mouse   720 --DLNREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKA-------FKSNPIPRNYYPMVQSAFIE 775

  Fly   777 DSSKRMVLLNDRSQGGASLEDGRLEMMLHRR--HIFADGSGAAEAINEQQFGKGLIARGKLFLYL 839
            |...|:|||.:|..|.:|..:|::|:|||||  :..|........:|:..     |....|:|.|
Mouse   776 DDKSRLVLLAERPHGVSSQGNGQVEVMLHRRLWNNLAWDLKYNLTLNDTS-----IVHPVLWLML 835

  Fly   840 N--------------AIEDG-ATASERVAEKE--IHLPF--WKFFSKSNNIQSDVTKTLSDFNDL 885
            .              |::.| ....:.:|::|  :|.|.  |           .||        |
Mouse   836 GPKSTMTALHPRSGVALQHGPVVLLKELADEETPVHGPHNPW-----------PVT--------L 881

  Fly   886 PQSVHLLTLE----PYSK---------------------DEILLRLENFLDQTEGNVVS----FS 921
            |.::||..|.    .||:                     ..:||||.:..:..|..|:|    ..
Mouse   882 PPNLHLQILSVPGWTYSRSHAQHLRNLQRGHPEKPQANLQRVLLRLRHLYEAGEDPVLSRPATVD 946

  Fly   922 IRQIFDDLGG-LEIRETTLDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASE 985
            ::.:...||. :.:.|.:|.|..   |::.|:..|..:...| :..:.||..:|....
Mouse   947 LKVVLRGLGSVVAVEERSLTGTW---DVQMLQRWHWSTKTDH-LKGHPTSPPRPPGGS------- 1000

  Fly   986 FSVTLKPMQIRTFIIK 1001
             .:|:.|.:||||.||
Mouse  1001 -IITVYPKEIRTFFIK 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_609250.2	PLN02701	20..820	CDD:178304	241/889 (27%)
		GH38N_AMII_LAM_like	37..311	CDD:212121	101/308 (33%)
Man2b2	NP_032576.2	PLN02701	27..807	CDD:178304	239/875 (27%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	116/356 (33%)