Protein Alignment LManIII and Man2b1

DIOPT Version :10

• Sequence 1: NP_609250.2
• Gene: LManIII / 34203
• FlyBaseID: FBgn0032066
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_001411770.1
• Gene: Man2b1 / 17159
• MGIID: 107286
• Length: 1024
• Species: Mus musculus
• Alignment Length: 1036
• Identity: 408/1036 - (39%)
• Similarity: 585/1036 - (56%)
• Gaps: 126/1036 - (12%)

  Fly    21 SEAVCYESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNK-----------HNIQHAGVQYI 74
            :.|..|::||.||..|:|:||:||:|||:||||||||||||..           .::|||.||||
Mouse    47 ARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGMDLDFLNFMPTVLSDVQHASVQYI 111

  Fly    75 FDTVVAELSKDSRRRFIQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNY 139
            .|:||:.|.:...||||.||..||::||:.|:...:..|:.||.:|||||..|.|.||||||.:|
Mouse   112 LDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHY 176

  Fly   140 QSVIDQFAVGLKFLNDNFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRV 204
            .:::||..:||:||.|.||..|.|||.|.||.|||||||||:||||.|||.|..|:|..||..|.
Mouse   177 GAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRK 241

  Fly   205 DNLGLEMVWDASETLE--EMDFFTGMLYNHYSAPPGFCFDSLCQDDPIIDG-KSYDNNVKSRVDD 266
            ..|.:|.:|.||::||  ..|.|||:|.|:|:.|...|:|.||.|.|::|. :|.:.|.|:.|:.
Mouse   242 KKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNY 306

  Fly   267 FLNYASNLAGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYSTAGCYL 331
            ||..||:..|:||:||.::.||.||.||||.|.:|||||||:.||.:|.:||..::.|||..|||
Mouse   307 FLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYL 371

  Fly   332 NSLHKSLQSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSVLADLSGEE 396
            ..|:|:..::..|..||.|::.....||||:|:|||..||:||...:.|||..||..|.   |.|
Mouse   372 WELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALV---GPE 433

  Fly   397 QH------KDLDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILGGANT-ARDALRVLTNQ 454
            .:      .|...|::.|||:|||||::||.:|.|.|||.|.| .|..|.... ..:||..|::.
Mouse   434 ANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQL-AAGWGPCEVLVSNALARLSHY 497

  Fly   455 PNGEFQSCLKLNISECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASEL 519
            .. .|..|.:||||.|. ..:.::.|.|||||||.....|.||:||.|.::.|.|.....::|.:
Mouse   498 KQ-NFSFCRELNISICP-VSQTSERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNV 560

  Fly   520 VPVPWEVLSLEFRNNDTQHELVFKASVNKI--ATYFIKKIDKTTEVDITVNTQTEQSVNEEESN- 581
            |.||      .:.:...|.||:|.|||..:  :||.:.|:               ..:|.:..|
Mouse   561 VMVP------SYYSETYQWELLFPASVPALGFSTYSVAKM---------------SDLNHQAHNL 604

  Fly   582 VKVPKRFKKVHSLKTDLETLDDQETIVQNSLIKLVIDNNTG---RLKTVEMNGVSEDIDQTFGMY 643
            :..|::.|..|.|            :::|..::...|:.||   :::.:|.| :|..:.|.|..|
Mouse   605 LSRPRKHKSHHVL------------VIENKYMRATFDSGTGLLMKIENLEQN-LSLPVSQGFFWY 656

  Fly   644 KTA--------RSCHYIFRQD----------ADLELVEDAFDFTVYDGESVKEVHQHVNEWISQV 690
            ..:        .|..||||.:          |.:.||:.|.         |:||||:.:.|.|||
Mouse   657 NASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTAL---------VQEVHQNFSAWCSQV 712

  Fly   691 IRIYEGVNRVEFEWLVGPVPIDDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSP 755
            ||:|:|...:|.||.|||:|:.|:.|||:::.|.:.:.:.|.|:|||||||:::|..|.|..::.
Mouse   713 IRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTL 777

  Fly   756 DLSEQPVSGNYYPVTSRMALQDSSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAI 820
            :.:| ||:||||||.:|:.:.|...::.:|.||||||:||:||.||:|:|||.:..|..|.:|.:
Mouse   778 NQTE-PVAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPL 841

  Fly   821 NEQQFGKGLIARGKLFLYLNAIEDGATASERVAEKEIHLP-FWKFFSKSNNIQSDVT-KTLSDFN 883
            .|...|..:  ||:..:.|:::.|.|.....:||:|:..| .......|:...|..| ||  .|:
Mouse   842 LETDTGDKV--RGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKT--QFS 902

  Fly   884 ----DLPQSVHLLTLEPYSKDEILLRLENFL------DQTEGNVVSFSIRQIFDDLGGLEIRETT 938
                :||..||||||..:....:|||||:..      |:...:.|:.:::.:|.......::|||
Mouse   903 GLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETT 967

  Fly   939 LDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQIRTFI 999
            |..|.|||...|||: ...:||        ||..:|...|.|      |||||||:||||:
Mouse   968 LAANQPLSRASRLKW-MTNTGP--------TSYPEPSKLDPT------SVTLKPMEIRTFL 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_609250.2	PLN02701	20..820	CDD:178304	346/843 (41%)
		GH38N_AMII_LAM_like	37..311	CDD:212121	148/287 (52%)
Man2b1	NP_001411770.1	None