DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManIII and Man2a1

DIOPT Version :9

Sequence 1:	NP_001285762.1	Gene:	LManIII / 34203	FlyBaseID:	FBgn0032066	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_032575.2	Gene:	Man2a1 / 17158	MGIID:	104669	Length:	1150	Species:	Mus musculus

Alignment Length:	1102	Identity:	273/1102 - (24%)
Similarity:	454/1102 - (41%)	Gaps:	236/1102 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRF 90
            ||: .|.....:.:.:|||||:|.|||||.:.|:...        .||||:.:|.:|.:||.|:|
Mouse   155 YEA-DEWDHEPLQVFVVPHSHNDPGWLKTFNDYFRDK--------TQYIFNNMVLKLKEDSSRKF 210

  Fly    91 IQVETGFFAKWWEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLND 155
            :..|..:.||||:.....||:.||:|:..|:||...|.|.|.|||..:|.::|||...|.::|..
Mouse   211 MWSEISYLAKWWDIIDIPKKEAVKSLLQNGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLEK 275

  Fly   156 NFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVW------- 213
            |.||  :||.||.||.||||...|.:..:..|......|:....|.....:..||..|
Mouse   276 NLGV--KPRSGWAIDPFGHSPTMAYLLKRAGFSHMLIQRVHYAIKKHFSLHKTLEFFWRQNWDLG 338

  Fly   214 DASETLEEMDFFTGMLYNHYSAP-PGFCFDSLCQ-DDPIIDGKSY------------DNNVKSRV 264
            .|::.|..|..|......|...| |..|    || |...:.|..|            ..||:||.
Mouse   339 SATDILCHMMPFYSYDIPHTCGPDPKIC----CQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRA 399

  Fly   265 DDFLNYASNLAGYYRSNHIMVPMGDDF---QYENAYMNYKNMDKLIKYVNERQASGSKYNIFYST 326
            ...|:.....:..:|:..::.|:||||   :|....:..:|.::|..|:|.:  ...|..|.:.|
Mouse   400 QMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQCRNYEQLFSYMNSQ--PHLKVKIQFGT 462

  Fly   327 AGCYLNSLHKSLQS--------FPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVA 383
            ...|.::|.|::.:        ||..:.||..::.....:|:|:|||||..||.:|.....::.|
Mouse   463 LSDYFDALEKAVAAEKKSSQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRIRAA 527

  Fly   384 KQLSVLADLSGEEQHKDLDYL-----------RQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAI 437
            :.|..|| |...:::|...:|           |:.:.:.|||||||||.|..|..||...|:.::
Mouse   528 EILYQLA-LKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSL 591

  Fly   438 LGGANTARDALRVLTNQPNGEFQS-----CLKLNISECAFTKENADDFM---------------V 482
            ........|:..:|..:....:||     .|:::      ||:::.|.:               :
Mouse   592 NSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMD------TKQSSQDSLPQKIIIQLSAQEPRYL 650

  Fly   483 TLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVASELVPVPWEVLSLEFRN-NDTQHELVFKASV 546
            .:|||........|.:.|...:.:|..:.|..|..::..| |.    :.|. :...:|:.|.|.:
Mouse   651 VVYNPFEQERHSVVSIRVNSATVKVLSDSGKPVEVQVSAV-WN----DMRTISQAAYEVSFLAHI 710

  Fly   547 NKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKKVHSLKTDLETLD----DQETI 607
            ..:..                                  |.||.:.|..:.....|    :.:.:
Mouse   711 PPLGL----------------------------------KVFKILESQSSSSHLADYVLYNNDGL 741

  Fly   608 VQNSL--IKLVIDNNTGRLKTVE---------MNGVSE-----------DIDQTFGMYKTA---- 646
            .:|.:  :|.::|  .|...|:|         .:|:.|           ::...|..|.|.
Mouse   742 AENGIFHVKNMVD--AGDAITIENPFLAIWFDRSGLMEKVRRKEDSRQHELKVQFLWYGTTNKRD 804

  Fly   647 RSCHYIFRQDADLE---LVEDAFDFTVYDGESVKEVHQHVNEWISQVIRIY--EGVNRVEFEWLV 706
            :|..|:|..|...:   .:...| ..|..|....:|...: |.::..:|:|  :|:.....| :.
Mouse   805 KSGAYLFLPDGQGQPYVSLRPPF-VRVTRGRIYSDVTCFL-EHVTHKVRLYNIQGIEGQSME-VS 866

  Fly   707 GPVPIDDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTS 771
            ..|.|.:...:|||....|.|::...:|||.||.::..|.         .:|:.|:..|.||:.:
Mouse   867 NIVNIRNVHNREIVMRISSKINNQNRYYTDLNGYQIQPRR---------TMSKLPLQANVYPMCT 922

  Fly   772 RMALQDSSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGKGLIARGKLF 836
            ...:||:..|:.||:.:|.|.:|:..|::|:.:.||.:..|..|..:.:::.:....|.   ::.
Mouse   923 MAYIQDAEHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLF---RIL 984

  Fly   837 LYLNAIEDGATASERVAEKEIHLPFWKFFSK---------------SNNIQSDVTKTLSDF---- 882
            |      :..:|.....||:..:.:....|.               |..:.|...:.||:|
Mouse   985 L------EKRSAVNMEEEKKSPVSYPSLLSHMTSSFLNHPFLPMVLSGQLPSPAFELLSEFPLLQ 1043

  Fly   883 NDLPQSVHLLTL--------EPYSKDEILLRLENFLDQTEGNVVSFSIRQIFDDLGGLEIRETTL 939
            :.||..:||:.|        :.|| ||..|.|..     :|....||.|       |:.:..:|.
Mouse  1044 SSLPCDIHLVNLRTIQSKMGKGYS-DEAALILHR-----KGFDCQFSSR-------GIGLPCSTT 1095

  Fly   940 DGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQIRTFIIK 1001
            .|.     |..||..:..:..| .||...:.:|.|..|   |:.||  |:|.||:|.||.|:
Mouse  1096 QGK-----MSVLKLFNKFAVES-LVPSSLSLMHSPPDA---QNMSE--VSLSPMEISTFRIR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_001285762.1	GH38N_AMII_LAM_like	37..311	CDD:212121	95/297 (32%)
		Alpha-mann_mid	358..433	CDD:286360	31/85 (36%)
		Glyco_hydro_38C	603..998	CDD:285047	102/452 (23%)
Man2a1	NP_032575.2	PLN02701	127..1148	CDD:178304	273/1102 (25%)
		GH38N_Man2A1	164..507	CDD:212131	108/358 (30%)
		Alpha-mann_mid	502..587	CDD:214875	31/85 (36%)
		Glyco_hydro_38C	757..1143	CDD:285047	98/430 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810