Protein Alignment LManIII and Man2a2

DIOPT Version :10

• Sequence 1: NP_609250.2
• Gene: LManIII / 34203
• FlyBaseID: FBgn0032066
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_766491.2
• Gene: Man2a2 / 140481
• MGIID: 2150656
• Length: 1152
• Species: Mus musculus
• Alignment Length: 1115
• Identity: 282/1115 - (25%)
• Similarity: 451/1115 - (40%)
• Gaps: 280/1115 - (25%)

  Fly    37 INIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRFIQVETGFFAKW 101
            :.:.:|||||:|.||:||.|:||...        .|:|.:::|::|.:|.||||:..|..|||||
Mouse   166 LQVFVVPHSHNDPGWIKTFDKYYTEQ--------TQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   102 WEDQSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLNDNFGVCGRPRVG 166
            |::.|..|:..|:.||..|:||...|.|.|.|||..:|.:::||...|.::|..|.|  ..||.|
Mouse   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   167 WQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVW------DASETLEEMDFF 225
            |.:|.||||.....:..:.........|:....|........||.:|      |:|     .|.|
Mouse   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQMWDSDSS-----TDIF 345

  Fly   226 TGML-YNHYSAP------PGFCFDSLCQDD-------------PIIDGKSYDNNVKSRVDDFLNY 270
            ..|: :..|..|      |..|    ||.|             .:......:.||..|....|:.
Mouse   346 CHMMPFYSYDVPHTCGPDPKIC----CQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQ 406

  Fly   271 ASNLAGYYRSNHIMVPMGDDFQYEN------AYMNYKNMDKLIKYVNER-----QASGSKYNIFY 324
            ....:..:|||.::||:||||:|:.      .:.||:   :|..::|.:     ||.       :
Mouse   407 YRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQ---RLFDFLNSKPEFHVQAQ-------F 461

  Fly   325 STAGCYLNSLHKSL--------QSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQ 381
            .|...|.::|:|..        ..||..:.||..::.....:|||::||||..|..:|.....|:
Mouse   462 GTLSEYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLR 526

  Fly   382 VAKQLSVLA-------DLSGEEQHKDLDYL---RQIMAVMQHHDAITGTEKQEVSNDYD-RLL-- 433
            .|:.|..||       .|:|:....|...|   |:.:.:.|||||||||.|:.|..||. |||
Mouse   527 GAEILYSLALAHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRS 591

  Fly   434 ------------YDAILGGANTARDALRVLTNQPNGEFQSCLKLNISECAFTKE-----NADDFM 481
                        :..:||...|       .:..|...|.......:|..|..:.     ::....
Mouse   592 LVSLKQVIINAAHYLVLGDQET-------YSFDPGTPFLQMDDSRVSHDALPERTVIRLDSSPRF 649

  Fly   482 VTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLV----------ASELVPVPWEVLSLEFR---- 532
            |.::|||.......|.:.|.....:|..|:|..:          |:::||..::| |:..|
Mouse   650 VVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDMVPDVYQV-SVPVRLPGL 713

  Fly   533 -------NNDTQHELVFKASVNKIATYFIKKIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFKK 590
                   ..|.......::||.   .|.       ..|.::|:.|:...|...:|..
Mouse   714 GLGVLQLQPDLDGPYTLQSSVR---VYL-------NGVKLSVSRQSAFPVRVVDSGA-------- 760

  Fly   591 VHSLKTDLETLDDQETIVQNSLIKLVIDNNTGRLKTVEMNGVSEDIDQ----TFGMYKTA----R 647
                         .:..:.|..:::.....||.||::..  |.|:.:|    .|.:|.|.    :
Mouse   761 -------------SDFAISNRYMQVWFSGLTGLLKSIRR--VDEEQEQQMELEFLVYGTRTSKDK 810

  Fly   648 SCHYIFRQDAD-----------LELVEDAF--DFTVYDGESVKEVHQHVNEWISQVIRIYE--GV 697
            |..|:|..|::           |.:.|..|  :..||        ::|.:    ||||:|.  ||
Mouse   811 SGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVY--------YEHFH----QVIRLYNLPGV 863

  Fly   698 NRVEFEWLVGPVPIDDELGKEIVTIFKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPV 762
            ..:..: :...|.|.|.:.||:.....:.|.|.|.|:||.||.::..|:.         |.:.|:
Mouse   864 EGLSLD-MSFQVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQY---------LKKLPL 918

  Fly   763 SGNYYPVTSRMALQDSSKRMVLLNDRSQGGASLEDGRLEMMLHRRHIFADGSGAAEAINEQQFGK 827
            ..|:||:.....:|||.:|:.|...::.|.:||.:|:||::|.||.:..|..|..:.:.:   .|
Mouse   919 QANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKD---NK 980

  Fly   828 GLIARGKLFLYLNAIEDGATASERVAEKE----------------------IHLPFWKFFSKSNN 870
            ....|.:|.|     |...|.|..|.:::                      :.||..|
Mouse   981 ITCNRFRLLL-----ERRTTMSPEVHQEQERSTSYPSLLSHLTSMYLSTPPLVLPVAK------- 1033

  Fly   871 IQSDVTKTLSDF----NDLPQSVHLLTLEPYSKDEILLRLENFLDQTEGNVVSFSIRQIFDDLGG 931
             :...:..|..|    :.||...|||.|.       :|..|:.|..|:..::..  |:.||  .|
Mouse  1034 -RQGTSPALRSFHPLASPLPCDFHLLNLR-------MLPAEDTLPATDSALILH--RKGFD--CG 1086

  Fly   932 LEIRE-----TTLDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLK 991
            ||.:.     ||..|.|.|..:    ||  |...:...|...|.|: |||:    .::...::|:
Mouse  1087 LEAKNLGFNCTTSQGKLALGSL----FH--GLDVTFLQPTSLTLLY-PLAS----PSNSTDISLE 1140

  Fly   992 PMQIRTFIIK 1001
            ||:|.||.::
Mouse  1141 PMEISTFRLR 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_609250.2	PLN02701	20..820	CDD:178304	233/901 (26%)
		GH38N_AMII_LAM_like	37..311	CDD:212121	93/305 (30%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	282/1115 (25%)