Protein Alignment LManIII and man2b2

DIOPT Version :10

• Sequence 1: NP_609250.2
• Gene: LManIII / 34203
• FlyBaseID: FBgn0032066
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_001106515.1
• Gene: man2b2 / 100127706
• XenbaseID: XB-GENE-1006292
• Length: 990
• Species: Xenopus tropicalis
• Alignment Length: 1107
• Identity: 285/1107 - (25%)
• Similarity: 468/1107 - (42%)
• Gaps: 233/1107 - (21%)

  Fly     7 LAILLALFASYIVQSEAVCYESCPETKSNMINIHLVPHSHDDLGWLKTVDQYYYGNKHNIQHAGV 71
            :.:||.|.:::    ..||..|     :..|...::||||.|:||:.||.:        ..||..
 Frog     1 MIVLLVLLSAW----GCVCTHS-----AQPIQAFVIPHSHMDVGWVYTVQE--------SMHAYA 48

  Fly    72 QYIFDTVVAELSKDSRRRFIQVETGFFAKWWE-DQSETKKKLVKTLVNEGRLEFTGGAWSMNDEA 135
            ..::.|||.||.:..|||||.||..||..||: .....:|:.|..|:.||||||..|...|:|||
 Frog    49 ANVYTTVVEELMRGDRRRFIVVEQEFFRLWWKLFAGNVEKQQVHQLMREGRLEFVIGGQVMHDEA 113

  Fly   136 AVNYQSVIDQFAVGLKFLNDNFGVCGRPRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDK 200
            .......|.|...|..|:.:.|||  |||..|.:|.||.|....::||...|:|...:|:|.:.|
 Frog   114 LTTIDDQILQLTEGHGFIYETFGV--RPRFSWHVDPFGASAASPTLFAMAGFNGHLISRIDYDTK 176

  Fly   201 NKRVDNLGLEMVWDASETL-EEMDFFTGML---------YNHYSAPPGFCFDSLCQ-DDPIIDGK 254
            ....:...|:.:|.||.:| ::.:.||.::         |..:|...||.::.:.. .||..||.
 Frog   177 ADMQNGKELQFIWRASPSLSDKQEIFTHVMDQYSYCTPSYIPFSDRSGFYWNGIAVFPDPPKDGM 241

  Fly   255 SYDNNVKSRVDDFLNYASNL-------AGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNE 312
            ..:.::....|....||..:       |.::||:.::.|.|.|.|:.||.:.:.|||.|:.|:|:
 Frog   242 YPNMSLPVTADTIHPYAETMVKNIKERAAWFRSSDVLWPWGCDKQFFNASVQFNNMDLLLDYINK 306

  Fly   313 RQASGSKYNIFYSTAGCYLNSLH-KSLQSFPNKTQDFLPHSHEAKSFWTGFFTSRPTQKRFERDG 376
            ....|  ..:.|||.|.|..:|: ::|......:|||||:|.::...||||:|||...|...|..
 Frog   307 HTEFG--VTVQYSTLGDYFKNLYNRNLTWGLRGSQDFLPYSSDSSQAWTGFYTSRNVLKGVARRA 369

  Fly   377 NHILQVAKQLSVLADLSGEEQH---------------KDLDYLRQIMAVMQHHDAITGTEKQEVS 426
            :.:|..|:        |...||               :.|..||..::.:||||.|||||..:|.
 Frog   370 SSLLYAAE--------SAFAQHLLKHPTGSVEKVWAMEQLRSLRWAVSEVQHHDGITGTESPKVR 426

  Fly   427 NDYDRLLYDAILGGANTARDALRVLTNQPNGEFQSCLKLNISECAFTKENADDFMVTLYNPLAHT 491
            :.|   :.:.:.|.|...:....::.:..:.:..||....|:             :|:|||||..
 Frog   427 DMY---IANLLQGAAGVRKLMAAIVMDLYSSQANSCGNGYIN-------------ITVYNPLAWD 475

  Fly   492 STQYVRVPVKEDSYQVTDEKGGLVASELVPVPWEVLSLEFRNNDTQHELVFKASVNKIATYFIK- 555
            .|.:|.||:......|.|:.|       .|||.::.:....:|.....::..........|.||
 Frog   476 VTTFVLVPMNNSVSGVYDKFG-------QPVPAQIQNATEPSNAFDLHILVTLKGLSYGRYSIKL 533

  Fly   556 -KIDKTTEVDITVNTQTEQSVNEEESNVKVPKRFK-KVHSLKTDLETLDDQETIVQNSLIKLVID 618
             ..|...:..:|         ..:.:.|:.|||.| |..:|.|.          :.|....:|||
 Frog   534 GSCDAANDRLVT---------GRKITFVRQPKRNKAKRQNLVTP----------IMNDCYTVVID 579

  Fly   619 NNTGRLKTV---EMNGVSEDIDQTFGMY-------KTARSCHYIFRQDADLELVEDAFDFTVYDG 673
            .||..|.::   |.|...: :.|.|..|       |...|.:|:|...........|....:..|
 Frog   580 QNTNLLHSITARESNQTVQ-VTQEFLEYHSNGDISKGPISDNYLFTSTGPAISAYKAVGLEIIAG 643

  Fly   674 ESVKEVHQHVNEWI----------SQVIRIYEGVNR------VEFEWLVGPVPIDDELGKEIVTI 722
            :.|.|:.|:....|          |::..:.||.::      :|..:.|||:    :|.:|.:..
 Frog   644 KLVTEIRQYFYSNITAQTYLYAVYSRIYNVPEGYDKSLVCHHIEQSYRVGPM----DLNRESIIR 704

  Fly   723 FKSGISSGGVFYTDSNGREMMRREKDKREDFSPDLSEQPVSGNYYPVTSRMALQDSSKRMVLLND 787
            ..:.:.:..:.|||:||.:|.||:       ..:.....|:.||||:.....::|:|.|:|.|::
 Frog   705 TSTDLRTDRLIYTDNNGYQMQRRQ-------FKNYDTNTVARNYYPMVRTAYIEDNSTRLVFLSE 762

  Fly   788 RSQGGASLEDGRLEMMLHRR---HIFAD---------------------GSGAAEAINEQQFGKG 828
            |:.|.:|.::|.:|:|||||   ::..|                     ||.|......|:.|..
 Frog   763 RAHGVSSQDNGEVEIMLHRRLWNNLEWDLNYNLTLNDTSVVRPTIWLMLGSRALAGALYQRLGMA 827

  Fly   829 LIARGKLFLYLNAIEDGATASERVAEK----------EIHL-----PFWKFFSKSNNIQSD---- 874
            |..|..:...|:      |..|:.:.|          .|||     |.|.:.|:.:....|
 Frog   828 LEHRPLVIYSLH------TGQEKRSYKTTDLPITLPDNIHLQILSIPGWFYSSRHHEHMQDIHTG 886

  Fly   875 -VTKTLSDFNDLPQSVHLLTLEPYSKDEILLRLENFLDQTEGNV----VSFSIRQIFDDLGGLE- 933
             :...::||:                 .:||||::..:..|..|    |:.:::.:...||.:.
 Frog   887 NIRDNVADFH-----------------RVLLRLQHLYETNEDPVLSKPVTINLQSLLKGLGTVSL 934

  Fly   934 IRETTLDGNLPLSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQIRTF 998
            :.|.:|.|...:..:||.|:..:..|...              .:.|...|:|::||.|.:|||.
 Frog   935 VEERSLTGTWDIHTLKRWKWKANIKGTDQ--------------REHTLGTSDFTITLSPKEIRTL 985

  Fly   999 II 1000
            .:
 Frog   986 FV 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManIII	NP_609250.2	PLN02701	20..820	CDD:178304	240/887 (27%)
		GH38N_AMII_LAM_like	37..311	CDD:212121	96/292 (33%)
man2b2	NP_001106515.1	PLN02701	19..783	CDD:178304	232/837 (28%)
		GH38N_AMII_Epman_like	22..346	CDD:212122	110/335 (33%)