DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IDH3B and Idh3a

DIOPT Version :9

Sequence 1:	NP_001317692.1	Gene:	IDH3B / 3420	HGNCID:	5385	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_001259705.1	Gene:	Idh3a / 32940	FlyBaseID:	FBgn0027291	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	150/353 - (42%)
Similarity:	230/353 - (65%)	Gaps:	13/353 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    31 AAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEE 95
            |..|||||.:     .|:..||::||||:|||:..||:::|.||.||:|::...::.|:....:.
  Fly    35 ATPAASRSYS-----SGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRGPDGKF 94

Human    96 KLEQ-VLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLD 159
            .:.| .:.|:..||:.:.|.:.||:. ||. .|.::.||::.:|:|||...:||.||.|.::::|
  Fly    95 GIPQAAIDSVNTNKIGLKGPLMTPVG-KGH-RSLNLALRKEFNLYANVRPCRSLEGYKTLYDDVD 157

Human   160 LVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKL 224
            :|.|||.||||||.:|||...||::.:|::|...|:|:|::||.||....|.|||.|||||||::
  Fly   158 VVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQYAKNNNRKKVTVVHKANIMRM 222

Human   225 GDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
            .|||||:|..::|:.:|:|:||...:|..|:.:||||.::||||||||||:|:.::.||||||.|
  Fly   223 SDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLG 287

Human   290 VVPGESYSAEYAVFET--GARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKV 352
            :.|..:.....|:||:  |.....|   |:::|||||:||||..||||:.|..::..|..|..:.
  Fly   288 LTPSGNMGLNGALFESVHGTAPDIA---GKDLANPTALLLSAVMMLRHMELNTYADKIERAAFET 349

Human   353 IKVGKVRTRDMGGYSTTTDFIKSVIGHL 380
            ||.||..|.|:||.:..::|...:...|
  Fly   350 IKEGKYLTGDLGGRAKCSEFTNEICAKL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IDH3B	NP_001317692.1	None
Idh3a	NP_001259705.1	Iso_dh	46..377	CDD:294303	143/335 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53770
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830