DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IDH3B and CG32026

DIOPT Version :9

Sequence 1:	NP_001317692.1	Gene:	IDH3B / 3420	HGNCID:	5385	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_729420.1	Gene:	CG32026 / 317829	FlyBaseID:	FBgn0052026	Length:	719	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	137/366 - (37%)
Similarity:	219/366 - (59%)	Gaps:	19/366 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    25 GLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQ 89
            |......|...|...:.:.||     :|::||||:|||:..||.::.:||..|:.|:...::.|.
  Fly   364 GQGQKGGAGGKSGKASGEPRV-----ITLMPGDGIGPEISMAVIKILEAAKTPLIFEPVDVTPVL 423

Human    90 NMASEEKL-EQVLSSMKENKVAIIGKIHTPMEYKGE-LASYDMRLRRKLDLFANVVHVKSLPGYM 152
            |......: |||:.||...||.:.|.:.||:   |. ..|.::.||:..:|:||:...:||||..
  Fly   424 NSQGMTSVPEQVIESMNRTKVGLKGPLMTPV---GTGFRSLNLTLRQLFNLYANIRPCRSLPGVE 485

Human   153 TRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVH 217
            |.:.::|:|.|||.||||||.:||....||::.:|::||..|.|:|::.|.||....|.|||||.
  Fly   486 TVYGDVDIVTIRENTEGEYSGIEHTLVNGVVQSIKLITRNASLRVAEYTFQYALAMKRKKVTAVA 550

Human   218 KANIMKLGDGLFLQCCEEVAELYPK------IKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNI 276
            ::.:|::.|||||:|..|:|..|..      ||:|...:...|:.:||:|.::|:||:|||||:|
  Fly   551 ESQVMRMSDGLFLRCVREMAAKYKSKMDQAGIKYEESTMTTVCLNIVQDPKRYDMLVLPNLYGDI 615

Human   277 IDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEY 340
            |.:..|||:||.|:.|..:.....|:||  :.|..|..: |:::|||||:|||:..||.::.|..
  Fly   616 ISDTCAGLIGGLGLTPSGNVGTNGAIFE--SVHGTAPDIAGKDLANPTALLLSSVMMLHYIGLHE 678

Human   341 HSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 381
            |:..|..||.|.|:...:||.|:||.:..:::..::|.:|:
  Fly   679 HADKIEKAVLKTIRDDNIRTMDLGGKAKCSEYTDALIKNLK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IDH3B	NP_001317692.1	None
CG32026	NP_729420.1	FGF-BP1	<281..361	CDD:284004
CG32026	NP_729420.1	Iso_dh	382..718	CDD:294303	133/345 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0473
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325037at33208
OrthoFinder	1	1.000	-	-		FOG0000244
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820