DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PrBP and Pde6d

DIOPT Version :9

Sequence 1:	NP_609246.1	Gene:	PrBP / 34196	FlyBaseID:	FBgn0032059	Length:	151	Species:	Drosophila melanogaster
Sequence 2:	NP_032827.1	Gene:	Pde6d / 18582	MGIID:	1270843	Length:	150	Species:	Mus musculus

Alignment Length:	151	Identity:	94/151 - (62%)
Similarity:	119/151 - (78%)	Gaps:	1/151 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSDDQSAGDRIQKGFQINYMILRDADSGKIIWQENKDFSAPDQEHEARVPVKILDMRAVSREIN 65
            |.:.|:.|.| |.:||::|:|.||||::|||:||..:|.|.|..|||||||.|||..:|||||:|
Mouse     1 MSAKDERARD-ILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELN 64

  Fly    66 FSTIESMENFRLDQKVLFKGRIMEEWFFEMGFVGANTTNTWQSTIEAAPESQMMPAKVLNGNVTI 130
            ||:.|.||.|||:|||.|||:.:||||||.|||..|:||||||.||||||||||||.||.|||.|
Mouse    65 FSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVII 129

  Fly   131 QTSFYDNETLITKSVVRLYYI 151
            :|.|:|::.|::.|.|||:|:
Mouse   130 ETKFFDDDLLVSTSKVRLFYV 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PrBP	NP_609246.1	GMP_PDE_delta	11..150	CDD:398820	89/138 (64%)
Pde6d	NP_032827.1	GMP_PDE_delta	10..149	CDD:398820	90/139 (65%)
Pde6d	NP_032827.1	Required for association with membranes. /evidence=ECO:0000250	144..150		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846938
Domainoid	1	1.000	191	1.000	Domainoid score	I3241
eggNOG	1	0.900	-	-		E1_KOG4038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1954
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3820
Isobase	1	0.950	-	0.845196	Normalized mean entropy	S242
OMA	1	1.010	-	-		QHG57142
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007479
OrthoInspector	1	1.000	-	-		oto94737
orthoMCL	1	0.900	-	-		OOG6_105846
Panther	1	1.100	-	-	LDO	PTHR12976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2716
SonicParanoid	1	1.000	-	-		X5607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740