Protein Alignment CG9289 and NLGN1

DIOPT Version :10

• Sequence 1: NP_609245.1
• Gene: CG9289 / 34195
• FlyBaseID: FBgn0032058
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 169/646 - (26%)
• Similarity: 263/646 - (40%)
• Gaps: 161/646 - (24%)

  Fly    72 EPKVFTTTVPDLGRLRG--RTLTTDWTGQKIMQFLDIPYGK----AERFRPAEPAPSWKGVLPAH 130
            :|.|.|    :.|::||  :.|..:..| .::|||.:||..    ..||:|.||...|..:..|.
Human    52 DPLVAT----NFGKIRGIKKELNNEILG-PVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNAT 111

  Fly   131 RPHAGCPSIQDLIVFAKLEE--------DGFDV---------EDCLRLSVNTKAMEGK------- 171
            :....||   ..|:..:|.|        :..||         ||||.|::.....:|.
Human   112 QFAPVCP---QNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTD 173

  Fly   172 ------------------SLPVMVYIHGDFF-------YDGDSVEAAPGYLLEHDVVLVSVRYRL 211
                              ..||||||||..:       ||| ||.|:.|     :|::::|.|||
Human   174 DLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDG-SVLASYG-----NVIVITVNYRL 232

  Fly   212 GPFGFLSTLTDEMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLS---- 272
            |..|||||......||..:.|:|.||:|..::|..|||||.|:|:||...|.:.||:||||
Human   233 GVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSE 297

  Fly   273 ----PAVPAGLFHRVIYQSGTALSPAFITDAPLGATKAIGRIAGCKQSTKVDQLNKCLNRLNATM 333
                .....|||.|.|.|||||||...::..|....:.:....||..|..| :|.:||.:.....
Human   298 GNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTV-ELVECLQKKPYKE 361

  Fly   334 LLAAFSVHGENQPSLSGGAYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYPTMGGSVKHGGTFML 398
            |     |..:.||:....|:|.   ||.|  .::|:.|..|:...:|..|..|.| |..|
Human   362 L-----VDQDIQPARYHIAFGP---VIDG--DVIPDDPQILMEQGEFLNYDIMLG-VNQG----- 410

  Fly   399 RDIFADIFNETILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQN--------DVKNGT 455
                             .|.::::.|::..:|.  |.|..:|:... |..|        ||...|
Human   411 -----------------EGLKFVENIVDSDDGI--SASDFDFAVSN-FVDNLYGYPEGKDVLRET 455

  Fly   456 FKRLTPGLIDLCSTISLKNPVLLVLQANAKKLP------------NSTYLYSFDYEGEQNRYATG 508
            .|.:.....|..:..:.:..:|.:...:....|            :.||.|:|.:..:.::....
Human   456 IKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAW 520

  Fly   509 EDEA--NFVPFDMGVSLTDDNLYLFPWPRFLALNSNRDLKVARRMVALWTSFATTGVPQAPGLP- 570
            .|.|  :.||:.:|:.:      :.|...|....|..|:.::..::..||:||.||.|..| :|
Human   521 ADAAHGDEVPYVLGIPM------IGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQ 578

  Fly   571 ---------------AWPAMNDETGPYMKIDRTVSFGDNY-LDEYRIAVEEAKHGYNLVND 615
                           ||...:.:...|:.|.......::| .::..:.:|...|.:|| ||
Human   579 DTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNL-ND 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9289	NP_609245.1	COesterase	71..598	CDD:395084	163/627 (26%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	163/631 (26%)