Protein Alignment CG9289 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_609245.1
• Gene: CG9289 / 34195
• FlyBaseID: FBgn0032058
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 685
• Identity: 190/685 - (27%)
• Similarity: 285/685 - (41%)
• Gaps: 158/685 - (23%)

  Fly    10 LLAIVLLAVFVAQGLAEKNANRQKQQKPRPGNQNFGIQKNKRPKPQKVQKQKPNKQQGQNGQE-- 72
            |||:.|:      |||.............||....|:                    |..|:|
Mouse     3 LLALCLV------GLAGAQRGGGGPGGGAPGGPGLGL--------------------GSLGEERF 41

  Fly    73 PKVFTTTVPDLGRLRG--RTLTTDWTGQKIMQFLDIPYGK----AERFRPAEPAPSWKGV----- 126
            |.|.|.    .||:||  |.|..:..| .::|||.:||..    |.||:|.|...||.||
Mouse    42 PVVNTA----YGRVRGVRRELNNEILG-PVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATT 101

  Fly   127 LPAHRP---HAGCPSIQDLIVFA-KLEEDGFDV----EDCLRLSV-------------------- 163
            ||...|   |...|:|...:.|. .||.....|    ||||.|::
Mouse   102 LPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNP 166

  Fly   164 -NTKAMEGKSLPVMVYIHGDFFYDG------DSVEAAPGYLLEHDVVLVSVRYRLGPFGFLSTLT 221
             :|...:....|||:::||..:.:|      .||.||.|     :|::|::.||||..|||||..
Mouse   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-----NVIVVTLNYRLGVLGFLSTGD 226

  Fly   222 DEMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLSPAVPAGLFHRVIYQ 286
            ....||..:.|.|.||:|:.::||.|||||:|:|:||...||:.||:|.||.. ..|||.:.|.|
Mouse   227 QAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHH-SEGLFQKAIAQ 290

  Fly   287 SGTALSPAFITDAPLGATKAIGRIAGCKQSTKVDQLNKCLNRLNATMLLAAFSVHGENQPSLSGG 351
            ||||:|...:...||..|:.:....||.:....:.: :||.|.::..|     |..:.||:....
Mouse   291 SGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAV-ECLRRKSSREL-----VDQDVQPARYHI 349

  Fly   352 AYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYPTMGGSVKHGGTFMLRD-------IFADIFNET 409
            |:|.   |:.|  .::|:.|..|:...:|..|..:.|..:..|...:.|       :.|..|:.|
Mouse   350 AFGP---VVDG--DVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFT 409

  Fly   410 ILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQ-NDVKNGTFKRLTPGLIDLCSTISLK 473
            :       ..::|.:.....|.|......:|    ::|. .|..||..:|.|  |:.|.:.....
Mouse   410 V-------SNFVDNLYGYPEGKDVLRETIKF----MYTDWADRDNGEMRRKT--LLALFTDHQWV 461

  Fly   474 NPVLLVLQANAKKLPNSTYLYSFDY----EG--EQNRYATGEDEANFVPFDMGVSL---TDDNLY 529
            .|.:...:.:| ...:..|.|:|.:    ||  |....|.|::    :|:..||.:   ||
Mouse   462 APAVATAKLHA-DYQSPVYFYTFYHHCQAEGRPEWADAAHGDE----LPYVFGVPMVGATD---- 517

  Fly   530 LFPWPRFLALNSNRDLKVARRMVALWTSFATTGVPQAPGLP----------------AWPAMNDE 578
            |||. .|    |..|:.::..::..||:||.||.|..| :|                .|...|.:
Mouse   518 LFPC-NF----SKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQDTKFIHTKPNRFEEVVWSKFNSK 576

  Fly   579 TGPYMKIDRTVSFGDNY-LDEYRIAVEEAKHGYNL 612
            ...|:.|.......||| .::....:|...|.:||
Mouse   577 EKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNL 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9289	NP_609245.1	COesterase	71..598	CDD:395084	174/608 (29%)
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	173/608 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836