Protein Alignment CG9289 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_609245.1
• Gene: CG9289 / 34195
• FlyBaseID: FBgn0032058
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 686
• Identity: 189/686 - (27%)
• Similarity: 284/686 - (41%)
• Gaps: 160/686 - (23%)

  Fly    10 LLAIVLLAVFVAQGLAEKNANRQKQQKPRPGNQNFGIQKNKRPKPQKVQKQKPNKQQGQNGQE-- 72
            |||:.|:      |||.............||....|:                    |..|:|
  Rat     3 LLALCLV------GLAGAQRGGGGPGGGAPGGPGLGL--------------------GSLGEERF 41

  Fly    73 PKVFTTTVPDLGRLRG--RTLTTDWTGQKIMQFLDIPYGK----AERFRPAEPAPSWKGV----- 126
            |.|.|.    .||:||  |.|..:..| .::|||.:||..    |.||:|.|...||.||
  Rat    42 PVVNTA----YGRVRGVRRELNNEILG-PVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATT 101

  Fly   127 LPAHRP---HAGCPSIQDLIVFA-KLEEDGFDV----EDCLRLSV-------------------- 163
            ||...|   |...|:|...:.|. .||.....|    ||||.|::
  Rat   102 LPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNP 166

  Fly   164 -NTKAMEGKSLPVMVYIHGDFFYDG------DSVEAAPGYLLEHDVVLVSVRYRLGPFGFLSTLT 221
             :|...:....|||:::||..:.:|      .||.||.|     :|::.::.||||..|||||..
  Rat   167 PDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-----NVIVATLNYRLGVLGFLSTGD 226

  Fly   222 DEMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLSPAVPAGLFHRVIYQ 286
            ....||..:.|.|.||:|:.::||.|||||:|:|:||...||:.||:|.||.. ..|||.:.|.|
  Rat   227 QAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHH-SEGLFQKAIAQ 290

  Fly   287 SGTALSPAFITDAPLGATKAIGRIAGCKQSTKVDQLNKCLNRLNATMLLAAFSVHGENQPSLSGG 351
            ||||:|...:...||..|:.:....||.:....:.: :||.|.::..|     |..:.||:....
  Rat   291 SGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAV-ECLRRKSSREL-----VDQDVQPARYHI 349

  Fly   352 AYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYPTMGGSVKHGGTFMLRD-------IFADIFNET 409
            |:|.   |:.|  .::|:.|..|:...:|..|..:.|..:..|...:.|       :.|..|:.|
  Rat   350 AFGP---VVDG--DVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFT 409

  Fly   410 ILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQ-NDVKNGTFKRLTPGLIDLCSTISLK 473
            :       ..::|.:.....|.|......:|    ::|. .|..||..:|.|  |:.|.:.....
  Rat   410 V-------SNFVDNLYGYPEGKDVLRETIKF----MYTDWADRDNGEMRRKT--LLALFTDHQWV 461

  Fly   474 NPVLLVLQANAKKLPNSTYLYSFDY----EG--EQNRYATGEDEANFVPFDMGVSL---TDDNLY 529
            .|.:...:.:| ...:..|.|:|.:    ||  |....|.|::    :|:..||.:   ||
  Rat   462 APAVATAKLHA-DYQSPVYFYTFYHHCQAEGRPEWADAAHGDE----LPYVFGVPMVGATD---- 517

  Fly   530 LFPWPRFLALN-SNRDLKVARRMVALWTSFATTGVPQAPGLP----------------AWPAMND 577
            |||      .| |..|:.::..::..||:||.||.|..| :|                .|...|.
  Rat   518 LFP------CNFSKNDVMLSAVVMTYWTNFAKTGDPNQP-VPQDTKFIHTKPNRFEEVVWSKFNS 575

  Fly   578 ETGPYMKIDRTVSFGDNY-LDEYRIAVEEAKHGYNL 612
            :...|:.|.......||| .::....:|...|.:||
  Rat   576 KEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNL 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9289	NP_609245.1	COesterase	71..598	CDD:395084	173/609 (28%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	172/609 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836