Protein Alignment CG9287 and TG

DIOPT Version :10

• Sequence 1: NP_609244.1
• Gene: CG9287 / 34194
• FlyBaseID: FBgn0032057
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_003226.4
• Gene: TG / 7038
• HGNCID: 11764
• Length: 2768
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 153/593 - (25%)
• Similarity: 236/593 - (39%)
• Gaps: 160/593 - (26%)

  Fly    41 LGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGC------- 98
            ||..|...:.|:|  ::|.||:.|.||.||....||:||.|:. |....||:..:..|
Human  2210 LGRSQAIQVGTSW--KQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQPGTRT 2271

  Fly    99 ---PSVVSMDSLRRLDDVLDVEDCLTMTITTP-NVTSRLPVLVYIHGEYLYEGSNSEAPP----D 155
               |.|              .||||.:.:..| ||.....|||:.|.  ..:...||..|    .
Human  2272 STSPGV--------------SEDCLYLNVFIPQNVAPNASVLVFFHN--TMDREESEGWPAIDGS 2320

  Fly   156 YLLE-KDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQ 219
            :|.. .::::||..||:|.|||||:.:.|:.||.|.||...||.:|:..|:.|||||.||::|..
Human  2321 FLAAVGNLIVVTASYRVGVFGFLSSGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAAD 2385

  Fly   220 VGGAAIA--HLLTLSPVVQRGLFHQVIYHSGSAIMP--IFLEEDPRKHAQEIAKKADCKMVTVRD 280
            .|||.:|  |||| :......||.:.:...|||:.|  :...|..::.|..:||:..|.|.:.::
Human  2386 RGGADVASIHLLT-ARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQE 2449

  Fly   281 LNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNFSYPAMG 345
            :.:||.:..|..|..|                   |..:...||  |.|.:..:::.:|    :.
Human  2450 VVSCLRQKPANVLNDA-------------------QTKLLAVSG--PFHYWGPVIDGHF----LR 2489

  Fly   346 GCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFV----------- 399
            ..|..|..|.|...||. ..|...||  ...|....|.:......:|...|:|.
Human  2490 EPPARALKRSLWVEVDL-LIGSSQDD--GLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGED 2551

  Fly   400 ------------------THDF--FNRNLMENGTFD-TLIPRLIDVAGTLNHKLPVLLALNMNNK 443
                              |.|:  |:|.| ||.|.| .:|..:||:|...             .|
Human  2552 SDARVEAAATWYYSLEHSTDDYASFSRAL-ENATRDYFIICPIIDMASAW-------------AK 2602

  Fly   444 HNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSRPDQSMAH 508
            ....|.|:|   :|.|...:..::...::|  |..|:..         ||.:..:.|..::|::.
Human  2603 RARGNVFMY---HAPENYGHGSLELLADVQ--FALGLPF---------YPAYEGQFSLEEKSLSL 2653

  Fly   509 RMVELWTNFVISGNPLGSARVGY--------------WPPMTTLYGPYMRIDDTMTIGGNYFTEF 559
            ::::.:::|:.||||      .|              ||            |.....||..:.||
Human  2654 KIMQYFSHFIRSGNP------NYPYEFSRKVPTFATPWP------------DFVPRAGGENYKEF 2700

  Fly   560 SATLSDEE 567
            |..|.:.:
Human  2701 SELLPNRQ 2708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	33..558	CDD:395084	149/582 (26%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:459665
		Thyroglobulin_1	662..724	CDD:459665
		TY	730..>776	CDD:469630
		TY	<892..922	CDD:469630
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:429604
		Type II. /evidence=ECO:0000269|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710	2188..2768		153/593 (26%)
		COesterase	2197..2718	CDD:395084	153/593 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2727..2768