Protein Alignment CG9287 and BCHE

DIOPT Version :10

• Sequence 1: NP_609244.1
• Gene: CG9287 / 34194
• FlyBaseID: FBgn0032057
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 147/623 - (23%)
• Similarity: 223/623 - (35%)
• Gaps: 169/623 - (27%)

  Fly     1 MQLLWWQIVSLLLVLQSVVESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVR 65
            ::.|:|.::..:|:          |:.:.|  |.|:.....|.::|..|..  ....|..|:.:.
Human    10 IRFLFWFLLLCMLI----------GKSHTE--DDIIIATKNGKVRGMNLTV--FGGTVTAFLGIP 60

  Fly    66 YAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGC--------PSVVSMDSLRRLDDVLDVEDCLTM 122
            ||:||.|..|||.|:.:..|.|:.:||.....|        |.....:......|:  .||||.:
Human    61 YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDL--SEDCLYL 123

  Fly   123 TITTP-----NVTSRLPVLVYIHGEYLYEGSNSEAPPD--YLLEKD-VVLVTPQYRLGPFGFLST 179
            .:..|     |.|    ||::|:|.....|::|....|  :|...: |::|:..||:|..|||:.
Human   124 NVWIPAPKPKNAT----VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLAL 184

  Fly   180 K-TDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQV 243
            . ..|.|||.|..|..||||:|:..|..|||:|..||:.|:..|||...|..||| ....||.:.
Human   185 PGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSP-GSHSLFTRA 248

  Fly   244 IYHSGS-----AIMPIFLEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALELL--TAFMEHA 301
            |..|||     |:..::   :.|.....:||...|......::..||......|:|  .||:.
Human   249 ILQSGSFNAPWAVTSLY---EARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVV-- 308

  Fly   302 LEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNFSYPAMGGCPKNAGSRVLNEIVDNDFEG 366
                                        ||...|..||                 ...||.||..
Human   309 ----------------------------PYGTPLSVNF-----------------GPTVDGDFLT 328

  Fly   367 KIPDDEYNTYNYIDHVIRQTVGTDKTMLL-----------------------TSFVTHDFFNRNL 408
            .:||           ::.:.....||.:|                       .|.:|...|...|
Human   329 DMPD-----------ILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGL 382

  Fly   409 -------MENGTFDTLI---------------PRLIDVAGTLNHKLPVLLALNMNNKHNP--DNT 449
                   .|.|....|.               ..|.||.|..|...|   ||....|.:.  :|.
Human   383 KIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICP---ALEFTKKFSEWGNNA 444

  Fly   450 FLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYP-EHVTRLSRPDQSMAHRMVEL 513
            |.|.|::           ..:.|..|...||....|..::|..| |.....::.::.::..:|:.
Human   445 FFYYFEH-----------RSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKR 498

  Fly   514 WTNFVISGNPLGSARVG-YWPPMTTLYGPYMRIDDTMT 550
            |.||...|||..:.... .||...:....|:.::...|
Human   499 WANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTEST 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	33..558	CDD:395084	142/591 (24%)
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	142/591 (24%)
		AChE_tetra	565..599	CDD:430146