DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and NLGN2

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	738	Identity:	166/738 - (22%)
Similarity:	262/738 - (35%)	Gaps:	212/738 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LPTLGSIQGKILETAW-----TKRE--------VLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVM 89
            |.:||..:..::.||:     .:||        |:||:.|.||.||.|..||:.|.....|..|.
Human    33 LGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVR 97

  Fly    90 DATAEKIGCPS------------VVSMDSLRRLDDVL--DVEDCLTMTITTPNVTSRL------- 133
            :||.....||.            |...|:|......:  ..||||.:.:..|.....|
Human    98 NATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEA 162

  Fly   134 ---------------PVLVYIHGEYLYEGSNSEAPPDYLLE-KDVVLVTPQYRLGPFGFLSTKTD 182
                           ||::::||....||:.:......|.. .:|::.|..||||..|||||...
Human   163 TLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQ 227

  Fly   183 EIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHS 247
            ...||.|.||...||:::...|.:|||||.|:|:.|...||:..:||.||. ...|||.:.|..|
Human   228 AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSH-HSEGLFQKAIAQS 291

  Fly   248 GSAIMPIFLEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHT 312
            |:||....:...|.|:.:.:|.|..|......:...||....:.||:...::.|
Human   292 GTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPA----------- 345

  Fly   313 GGIQFTIG-GP---SGVLPKHPYDLMLETNF-SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDE 372
               ::.|. ||   ..|:|..|..||.:..| :|..:.|..:..|.:.:.:..:::........:
Human   346 ---RYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFD 407

  Fly   373 YNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTF--DTLIPRLIDVAGTLNHK--LP 433
            :...|::|::.....|.|.......|:..|:.:|   :||..  .||:....|      |:  .|
Human   408 FTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADR---DNGEMRRKTLLALFTD------HQWVAP 463

  Fly   434 VLLALNMNNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTR 498
            .:....::..:.....|...:.:.....|.:..|.....:.|:..||.:.. |..|||     ..
Human   464 AVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVG-ATDLFP-----CN 522

  Fly   499 LSRPDQSMAHRMVELWTNFVISGNP-----------------------------------LG--- 525
            .|:.|..::..::..||||..:|:|                                   :|
Human   523 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKP 587

  Fly   526 -------SARVGYW---------------------PPMTTLYGP--------------------- 541
                   :.:|.:|                     ||..|.:.|
Human   588 RVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPE 652

  Fly   542 ---------YMRIDDTMTIGGNYFTEFSATLSDEEQGHSLI-------REVYYLRSRSRKRALNK 590
                     |.|....   ..:|.||.|.|::   .|.||:       ..:||.|.
Human   653 PEPEPGPRAYDRFPGD---SRDYSTELSVTVA---VGASLLFLNILAFAALYYKRD--------- 702

  Fly   591 RRKQLAKSNARRLQNPKLGGRKS 613
            ||::|   ..|||..|  ||..|
Human   703 RRQEL---RCRRLSPP--GGSGS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	146/674 (22%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	135/589 (23%)
		Aes	<170..>268	CDD:223730	34/97 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668		6/44 (14%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740