DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and ces2b

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	576	Identity:	169/576 - (29%)
Similarity:	245/576 - (42%)	Gaps:	103/576 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMD 90
            |...|.|:..|....|||::|..:........:..:..:.:|:.|.|..|...|:|.:.|:.|.|
Zfish   546 RILSERKEGPVVNTKLGSLRGSYMMAKGKDSVISSYFAIPFAKSPVGPLRLTPPQPADAWQGVRD 610

  Fly    91 ATAEKIGC--PSVVSMDSLRRL---DDVLDV-EDCLTMTITTPNV---TSRLPVLVYIHGEYLYE 146
            ||.:...|  |..|.:|.|..:   .:..:| ||||.:.|.||:.   ..:|||:|:|||..|..
Zfish   611 ATKQPPMCLQPKEVMVDLLATMPLKTEFPEVSEDCLYLNIYTPSKPGDNKKLPVMVWIHGGGLAF 675

  Fly   147 GS----NSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYF 207
            ||    ::.|...|   :|:|:|..|||||..||.||..:..|||.|.||...|||:|:..|..|
Zfish   676 GSASIFDAHALAAY---QDIVVVMVQYRLGLLGFFSTGDEHAPGNYGLLDQVAALQWVQENIHSF 737

  Fly   208 GGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKAD 272
            ||||..|||.|:..|...|.||.||| :...|||:.|..||:|.|...:..||...|:.:...:.
Zfish   738 GGDPGSVTVFGESAGGVSASLLVLSP-LSANLFHRAIAESGTAAMNAIMSPDPLSTARSLGNVSG 801

  Fly   273 CKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLET 337
            |.:.:.:.:..|:|::|..::|....|..|    |..|.|...||        |||...:|:...
Zfish   802 CDISSTKKIVDCVMQMTEEDILKIAREQVL----LRFGVTVDGQF--------LPKSVDELLQSQ 854

  Fly   338 NFS-YPAMGGCPKNAGSRVLNE-IVDNDFEGKIPDDE----YNTYNY-------IDHVIRQTVG- 388
            .|| .|.|.|...:.|...|.| |....:...:..|:    ..||||       .:.|:::.:|
Zfish   855 EFSKVPLMTGVTDDDGGFTLPEFIAPPGWRDGMTKDQIMPFLPTYNYDLQDPGLAEIVLKEYLGA 919

  Fly   389 -TDKTMLLTSF--VTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLPVLLALNMNNKHNPDN-- 448
             |||..:...|  :..|||                         ..||   |..:.|.|....
Zfish   920 TTDKIKIRDGFREIVGDFF-------------------------FNLP---ARKLANYHRDTGAP 956

  Fly   449 TFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPY---PEHVT---RLSRPDQSMA 507
            .::|.|.:.....:.|.         |...|....||.|::|.|   ..|:.   .||:.:|.:.
Zfish   957 VYMYEFQHPAYIFQNKR---------PSFVGCDHGDELLFVFGYCFGNGHIKVEGELSKEEQELC 1012

  Fly   508 HRMVELWTNFVISGNPLGSARVGYWPPMTTLYG---PYMRI----DDTMTIGGNYF 556
            ...:..|.||..:|||.|...| .||.    ||   .|:.|    ..:....||:|
Zfish  1013 KTTMAYWGNFARTGNPNGPGLV-EWPK----YGAEAEYLGIGLEQKSSKNFKGNHF 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	167/571 (29%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613
		COesterase	553..1065	CDD:306613	166/569 (29%)
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920