DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	778	Identity:	182/778 - (23%)
Similarity:	278/778 - (35%)	Gaps:	243/778 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SRVRGRQYDEEKDTIVE-LPTLGSIQGKILETAW-------------------------TKREVL 59
            ||:||..:...  |:|. |.||......:|..||                         ...|:|
Zfish     2 SRLRGTPWIPL--TMVHPLATLRLFTWIVLAAAWLAITWAQQHPIVTTNYGKLRGLKTPLPNEIL 64

  Fly    60 ----QFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSMDSLRRLDDVLDV---- 116
                |::.:.||.||||..||:.|.|...|..:.:||.....||..:....|  |:|:|.|
Zfish    65 GPVEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFLEDRFL--LNDMLPVWFTA 127

  Fly   117 -------------EDCLTMTITTP------------------------NVTSRLPVLVYIHGEYL 144
                         ||||.:.|..|                        :.....||:|||||...
Zfish   128 NLDTVVTYVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSY 192

  Fly   145 YEGSNSEAPPDYLLE-KDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFG 208
            .||:.:......|.. .:|::||..||||..|||||......||.|.||...||:::|..|:.|.
Zfish   193 MEGTGNMIDGSILASYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFK 257

  Fly   209 GDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADC 273
            |||.|||:.|...||:...|||||. ....||.:.|..||:|:....:...|.|:.:.:|:|..|
Zfish   258 GDPKRVTIFGSGAGASCVSLLTLSH-YSEDLFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVGC 321

  Fly   274 KMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETN 338
            .|:...||..||......||:..::..|  |..:..|.      .|.|  .|:|..|..||.:..
Zfish   322 NMLDSIDLVECLQNKNYKELIEQYITQA--KYHIAFGP------VIDG--DVIPDDPQILMEQGE 376

  Fly   339 F-SYPAMGGCPKNAGSRVLNEIVD-------NDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLL 395
            | :|..|.|..:..|.:.::.|||       |||:..:.|       ::||:.....|.|.....
Zfish   377 FLNYDIMLGVNQGEGFKFVDGIVDSEDGVSANDFDFAVSD-------FVDHLYGYPEGKDTLRET 434

  Fly   396 TSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHK--LPVLLALNMNNKHNPDNTFLYSFDYAG 458
            ..|:..|:.::...|... .||:....|      |:  .|.:...:::.::. ..|:.|:|
Zfish   435 IKFMYTDWADKENPETRR-KTLVALFTD------HQWVAPAVATADLHAQYG-SPTYFYAF---- 487

  Fly   459 EFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPE------HVTRLSRPDQSMAHRMVELWTNF 517
                |.....|   ..|..:..:..||..|:|..|.      .....|:.|..::..::..||||
Zfish   488 ----YHHCQSE---MKPSWSDSAHGDEVPYVFGIPMLGPTDLFNCNFSKNDVMLSAVVMTYWTNF 545

  Fly   518 VISGNP-----------------------------------LG----------SARVGYW----- 532
            ..:|:|                                   :|          :.:|.:|
Zfish   546 AKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVP 610

  Fly   533 ------------------PPMTTLYGPYMR--------------------------------IDD 547
                              ||..|...||.:                                .||
Zfish   611 HLHNINELFQYVSTTTKIPPQDTTPFPYTKRLGKTWPSTTRHPGVPPANTKQTTDQRKGNDLSDD 675

  Fly   548 TMTI---GGNYFTEFSATLSDEEQGHSLI-------REVYYLRSRSRKRALNKRRKQLAKSNA 600
            :..:   ..:|.||.|.|::   .|.||:       ..:||.:.: |:...|:|.....:::|
Zfish   676 SAVVIETKRDYSTELSVTIA---VGASLLFLNILAFAALYYKKDK-RRHESNRRGPSPQRNSA 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	165/717 (23%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	148/600 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740