DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and ces3

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001038401.1	Gene:	ces3 / 560651	ZFINID:	ZDB-GENE-030131-9563	Length:	549	Species:	Danio rerio

Alignment Length:	593	Identity:	171/593 - (28%)
Similarity:	253/593 - (42%)	Gaps:	142/593 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAE 94
            |:...:|.|.. ||::|:.::...:...|.|::.:.:|:||.|.||..||:|::.||.:.:||..
Zfish    23 EDSGPVVVLKH-GSVRGQYVKAKGSPAVVEQYLGIPFAQPPVGPHRLAAPQPVQGWEGIRNATEY 86

  Fly    95 KIGC---PSVV---SMDSLRRLDDVLDVEDCLTMTITTPNVTS---RLPVLVYIHGEYL------ 144
            ...|   |::|   :......|......||||.:.:.||:..|   :.||:|:|||..|
Zfish    87 SSMCLQDPNIVPKYAKSMTLELPPTGVSEDCLYLNVYTPSQRSESDKFPVMVWIHGGALVIGGAC 151

  Fly   145 -YEGSNSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFG 208
             |:|:     |....|| ||:|..|||||..|:|||......||.||||...|||:|:..|:.||
Zfish   152 MYDGT-----PLAAYEK-VVVVVIQYRLGILGYLSTGDQHAQGNWGFLDQIAALQWVQQNIEAFG 210

  Fly   209 GDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADC 273
            |||..||:||:..|...|.||||||:. :|||.:.|:.||.|.:..:..:||..:|:.||...:|
Zfish   211 GDPQSVTIAGESAGGISASLLTLSPMT-KGLFQRAIFQSGVATVKGYSFKDPLTYAKVIANITEC 274

  Fly   274 KMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVL-----PKHPYDL 333
            ...:...|..|:.|:|..:::.|    |.:|..|. |.|...:|....|..:|     ||.|. |
Zfish   275 DFSSSEVLVKCIREMTEEQIIKA----AQKKYRLP-GATVDGEFIKAQPEEILKSKDFPKIPI-L 333

  Fly   334 MLETNFSYP------------AMGGCPK----------NAGSRVLNEIVDNDF--EGKIPDDEYN 374
            :..||..:.            |.|...|          |||:...|.|:.:::  ..|.|::
Zfish   334 VGTTNHEFGWTLSHAILPKDWAKGMDAKSAKQTLDFFYNAGASEANGIIADEYFKNAKTPEE--- 395

  Fly   375 TYNYIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHK---LPVLL 436
                    ||                 |.|...|   |....:||. |.||.  .|:   .||.:
Zfish   396 --------IR-----------------DAFTELL---GDIIMVIPS-IKVAS--YHRDAGAPVYM 429

  Fly   437 ALNMNNKHNPD--NTFLYSF---DYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHV 496
               ...:|.|.  |.|..||   |:..|..              |..|....|..:       .|
Zfish   430 ---YEFQHGPSIANKFRPSFVKADHGDEIG--------------FMFGACFWDGQV-------KV 470

  Fly   497 T-RLSRPDQSMAHRMVELWTNFVISGNPLGSARVGYWPPMTTLY---GPYMRIDDTMTIGGN--- 554
            | .|:..:..:...:::.|.|||.:|:| ..|.|. ||    :|   ..|:.:....|.|..
Zfish   471 TGTLTEEENQLCRTVMKYWANFVRTGSP-NPAPVP-WP----VYDQSNKYLNLGLQQTEGQGLKK 529

  Fly   555 ----YFTE 558
                :|||
Zfish   530 DKLLFFTE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	168/590 (28%)
ces3	NP_001038401.1	COesterase	24..535	CDD:278561	167/588 (28%)
ces3	NP_001038401.1	Aes	<122..>235	CDD:223730	53/118 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840