DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and Ces2h

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	162/603 - (26%)
Similarity:	255/603 - (42%)	Gaps:	105/603 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLVLQSVVESRVRGRQYDEEKDTIVELPT--LGSIQGKILETAWTKREVLQFVDVRYAEPPTGL 73
            |||:||      |:|      :|::..:.|  .|.|.|.::........|..|:.:.:|:||.|.
  Rat    17 LLLLLQ------VQG------QDSLSPIRTTHTGQILGSLIHMKGLDVGVHSFLGIPFAKPPIGP 69

  Fly    74 HRFKAPRPIEPWEDVMDATAEKIGC---PSVVSMDSLRRLDDVLDV----EDCLTMTITTPNVT- 130
            .||..|...|||..|.|.|:....|   .:.::|.:.:.|...|.:    ||||.:.|.|||..
  Rat    70 LRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYTPNHAH 134

  Fly   131 --SRLPVLVYIHG-------EYLYEGSNSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPG 186
              |.|||:|:|||       ..||:||...|      .::||:||.|||||..||.||......|
  Rat   135 EGSNLPVMVWIHGGALVIGMASLYDGSMLAA------MENVVVVTIQYRLGVLGFFSTGDQHARG 193

  Fly   187 NAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAI 251
            |.|:||...||.:|:..|.:|||:|.|||:.|:..|........:|| :.|||||..|..||.|:
  Rat   194 NWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSP-MSRGLFHGAIMESGVAL 257

  Fly   252 MPIFLEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQ 316
            |...:........:.:|..:.|:.|..:.|..||...:..|::      ::.|:         .:
  Rat   258 MSSLISVSSDVVYRTVANLSGCEQVDSKALVNCLRGKSEEEIM------SINKA---------FR 307

  Fly   317 FTIGGPSGV-LPKHPYDLMLETNF-SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYI 379
            ...|...|: ||:||.:|:...:| ..|::.|             |:||..|.|......|.:..
  Rat   308 IISGIVDGIFLPRHPKELLASADFHPIPSIIG-------------VNNDEYGWIIPSSMTTTDSK 359

  Fly   380 DHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDV-----AGTLNHKLPVLLALN 439
            ..:.||.|.......:...:....|:..|:|....|:..|:.:.|     .......:|.|...:
  Rat   360 KKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEYMGDSEDPQFLQVQFKEMMEDFTFVIPALQVAH 424

  Fly   440 MNNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFP--YPEHVTRLSRP 502
            ....:.|  .:.|.|.:...|  :|:       ..|........||.|::|.  :......|:..
  Rat   425 FQRSNAP--VYFYEFQHRPSF--FKD-------SKPPHVKADHGDEILFIFRSFWGGTQVDLTEE 478

  Fly   503 DQSMAHRMVELWTNFVISGNPLGSARVGYWPPMTTLYG---PYMRIDDTMTIGG-------NYFT 557
            ::.::.||::.|.||...||| .|..:.|||    ::.   .|:::|....:|.       .::|
  Rat   479 EELLSRRMMKYWANFARQGNP-NSEGLPYWP----VFDHDEQYLQLDTQPAVGRALKAKRLQFWT 538

  Fly   558 ----EFSATLSDEEQGHS 571
                |....|.|.|..|:
  Rat   539 KTLPEKIRELKDTEDRHT 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	150/568 (26%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	148/557 (27%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	47/108 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336459
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740