DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	159/574 - (27%)
Similarity:	251/574 - (43%)	Gaps:	101/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQLLWWQIVSL--LLVLQSVVESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQFVD 63
            :|:.|.:::.:  .||...|.:.|:      ....|::.....|.::|...:|.:.|.....|..
  Fly     3 VQVGWPKLIKMGAQLVGHKVQQYRL------STGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEG 61

  Fly    64 VRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSMDSLRRLDDVLDVEDCLTMTITTPN 128
            :.||:||.|..||:||:|.|||:.|::.|..:     ...|.....|..|...||||.:.:....
  Fly    62 IPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNR-----SKPMQRNMLLGIVEGSEDCLHLNVYVKA 121

  Fly   129 VTSR--LPVLVYIHGEYLYEGSNSE--APPDYLLEKDVVLVTPQYRLGPFGFLSTKTD--EIPGN 187
            :.|.  |||:|:|:|....:|..|.  ..|||.::|.||.|...|||...||||.|..  ::|||
  Fly   122 LKSEKPLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGN 186

  Fly   188 AGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIM 252
            ||..|..:||:::...|.:|.|||:.:|:.|:..|:|..|:: ::....|||||:.|..||.|:.
  Fly   187 AGLKDQVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVM-MTTEQTRGLFHKAIMQSGCALS 250

  Fly   253 PIFLEEDPRKH-----AQEIAKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHT 312
            .  ..|.|..:     ||.:..|.|.|...|         |:.|..:.|....|:::..:.:...
  Fly   251 E--WVESPDNNWAFRLAQNLGYKGDEKDADV---------LSFLSKVCARQIAAIDQDVINLDEV 304

  Fly   313 GGIQFTIGGP--------SGVLPKHPYDLMLET--NFSYPAMGGCPKNAGSRVLNEIVDNDFEG- 366
            ........||        ..|:||...||:.|.  |.....:||               |.|||
  Fly   305 RSFLLFAFGPVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGG---------------NSFEGL 354

  Fly   367 -------KIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTFDTLIPRLIDV 424
                   |.|....|.:|.:...:|:|...:...||...:...:||..:.|:       ..:.:.
  Fly   355 FSYQLVRKDPWALKNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQES-------MEMFEA 412

  Fly   425 AGTLNHKL------PVLLALNMNNKHNPDNTFLYSFDY-AGEFNRYKEMDEETNLQSPFKAGVSL 482
            ....:|:.      ..:||........|  |:||.||: :..||:::.:.....::     ||:.
  Fly   413 LNIFSHRQIWHDTHRFILARQSYAPKTP--TYLYRFDFDSPHFNQFRRLVCGDRIR-----GVAH 470

  Fly   483 TDEALYLFPYPEHVTRLSRPDQSMAH----RMVELWTNFVISGNP----LGSAR 528
            .||..||| |....::|.:  .||.:    |||.:||:|..||||    ||||:
  Fly   471 ADELSYLF-YNIIASKLDK--SSMEYKTIERMVGMWTSFASSGNPNCPELGSAK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	153/542 (28%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	153/539 (28%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	39/103 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467458
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900