DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and Ces3a

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_941074.1	Gene:	Ces3a / 382053	MGIID:	102773	Length:	571	Species:	Mus musculus

Alignment Length:	563	Identity:	164/563 - (29%)
Similarity:	259/563 - (46%)	Gaps:	86/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WQIVSLLLVLQSVVESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPP 70
            |....||:...:|:..:|.    ..|.||     .||.::|:.:....|.|.|..|:.:.:|:.|
Mouse    17 WMACLLLIFPTTVIGPKVT----QPEVDT-----PLGRVRGRQVGVKDTDRMVNVFLGIPFAQAP 72

  Fly    71 TGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSMDSLRR--LDDVLDV----EDCLTMTITTP-N 128
            .|..||.||.|.:|||.|.||:.....|...|...|..|  |::.:.:    |||||:.|.:| .
Mouse    73 LGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTE 137

  Fly   129 VTS--RLPVLVYIHGEYLYEGSNSEAPPDYLLE-KDVVLVTPQYRLGPFGFLSTKTDEIPGNAGF 190
            :|:  :.||:|:|||..|..||::......|.. .|||:||.|||||.||||||....:|||.||
Mouse   138 ITAGDKRPVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGF 202

  Fly   191 LDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIF 255
            ||:..||::|:..|..|||||:.||:.|...|..|...|.||| :..||||:.|..||..|..|.
Mouse   203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSP-MSAGLFHRAISQSGVVISKIL 266

  Fly   256 LEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIG 320
            .:.:....||..|....|...:..:|..||::....:|:|        |.::.|.:|....|
Mouse   267 EDLNAWSEAQNFANSVACGSASPAELVQCLLQKEGKDLIT--------KKNVNISYTVNDSF--- 320

  Fly   321 GPSGVLPKHPYDLMLETNF-SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYIDHVIR 384
                 .|:.|..|:....| :.|.:.|            :.:::| |.:....:|..:.::|:.:
Mouse   321 -----FPQRPQKLLANKQFPTVPYLLG------------VTNHEF-GWLLLKFWNILDKMEHLSQ 367

  Fly   385 QTVGTDKTMLLTSF---------VTHDFFNRNLMENGTFDTLIPR--LIDVAGTLNHKLPVLLAL 438
            :.:..:...||...         |..::     ::||: |....|  |.::.|.:...:|.|:.
Mouse   368 EDLLENSRPLLAHMQLPPEIMPTVIDEY-----LDNGS-DESATRYALQELLGDITLVIPTLIF- 425

  Fly   439 NMNNKHNPD---NTFLYSFDYA-GEFNRYK----EMDEETNLQSPFKAGVSLTDEALYLFPYPEH 495
               :|:..|   ..|||.|.:. ..|.::|    :.|..:.....| .|..||||: .|..:||
Mouse   426 ---SKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKADHSSENAFVF-GGPFLTDES-SLLAFPE- 484

  Fly   496 VTRLSRPDQSMAHRMVELWTNFVISGNPLGSARVGYWPPMTTL 538
               .:..::.::..|:..|:.|..:|||.|.. :..||.:..|
Mouse   485 ---ATEEEKQLSLTMMAQWSQFARTGNPNGKG-LPPWPQLNQL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	159/538 (30%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	159/540 (29%)
		Aes	75..>245	CDD:223730	73/169 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740