Protein Alignment CG9287 and AADACL2

DIOPT Version :10

• Sequence 1: NP_609244.1
• Gene: CG9287 / 34194
• FlyBaseID: FBgn0032057
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_997248.2
• Gene: AADACL2 / 344752
• HGNCID: 24427
• Length: 401
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 87/414 - (21%)
• Similarity: 150/414 - (36%)
• Gaps: 131/414 - (31%)

  Fly    76 FKAPRP---IEPWEDV-MDATAEKIGCP-SVVSMDSLR------------RLDDVLDVED-CLTM 122
            |..|.|   .|.|:.: :||.|:.  |. :.:..:::|            |||....:.| .:|:
Human    19 FYTPMPDNIEESWKIMALDAIAKT--CTFTAMCFENMRIMRYEEFISMIFRLDYTQPLSDEYITV 81

  Fly   123 TITT----------PNVTS--RLPVLVYIHGEYLYEGSNSEAPPDYLLE-----KDVVLVTPQYR 170
            |.||          |...|  |...::|.||.....||:.:...|:|..     .|.|:|...||
Human    82 TDTTFVDIPVRLYLPKRKSETRRRAVIYFHGGGFCFGSSKQRAFDFLNRWTANTLDAVVVGVDYR 146

  Fly   171 LGPFGFLSTKTDEIPGNAGFLDIFLALQF--VKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSP 233
            |.|       ....|  |.|.|...|::|  ::..:..:|.||:|:.:||...|..:|..:|...
Human   147 LAP-------QHHFP--AQFEDGLAAVKFFLLEKILTKYGVDPTRICIAGDSSGGNLATAVTQQV 202

  Fly   234 VVQRGLFH----QVIYHSGSAIMPIFL-EEDPRKHAQEIAKKADCKMVTV-------------RD 280
            .....:.|    ||:.:.|..|...:| .....:|...:.:....|:|::             |:
Human   203 QNDAEIKHKIKMQVLLYPGLQITDSYLPSHRENEHGIVLTRDVAIKLVSLYFTKDEALPWAMRRN 267

  Fly   281 LNTCLMELTALELLTAFMEHAL---EKSDLGIGHT----GGIQFTIGG--PSGVLP--------- 327
            .:   |.|.:..|. .|:..::   ||......:|    ||:.:::.|  .|..||
Human   268 QH---MPLESRHLF-KFVNWSILLPEKYRKDYVYTEPILGGLSYSLPGLTDSRALPLLANDSQLQ 328

  Fly   328 ----------KHPYDLMLETNFSYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYIDHV 382
                      :|  ||:.:....|...   .:|.|.:|::|.:::...|.:
Human   329 NLPLTYILTCQH--DLLRDDGLMYVTR---LRNVGVQVVHEHIEDGIHGAL-------------- 374

  Fly   383 IRQTVGTDKTMLLTSFVTHDFFNR 406
                          ||:|..|:.|
Human   375 --------------SFMTSPFYLR 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	33..558	CDD:395084	87/414 (21%)
AADACL2	NP_997248.2	Abhydrolase_3	107..372	CDD:400284	60/282 (21%)
		Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3	111..113		1/1 (100%)