DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and Tg

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	150/605 - (24%)
Similarity:	235/605 - (38%)	Gaps:	170/605 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VELPTLGSIQG--KILE--TAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKI 96
            |.:.:.|.:||  ::::  |||  ::|.||:.|.||.||...:||:||..:. |....|||..:.
  Rat  2202 VHIDSFGQLQGGSQVVKVGTAW--KQVYQFLGVPYAAPPLAENRFQAPEVLN-WTGSWDATKLRS 2263

  Fly    97 GC---------PSVVSMDSLRRLDDVLDVEDCLTMTITTP-NVTSRLPVLVYIHGEYLYEGSNSE 151
            .|         |..:|             ||||.:.:..| |:.|...|||:.|.....|||..:
  Rat  2264 SCWQPGTRTPTPPQIS-------------EDCLYLNVFVPENLVSNASVLVFFHNTVEMEGSGGQ 2315

  Fly   152 APPD---YLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSR 213
            ...|   .....::::||..||||.|||||:.:||:.||.|.||...||.:|:..|..|||||.|
  Rat  2316 LNIDGSILAAVGNLIVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQTHIGAFGGDPQR 2380

  Fly   214 VTVAGQVGGAAIA--HLLTLSPVVQRGLFHQVIYHSGSAIMP--IFLEEDPRKHAQEIAKKADCK 274
            ||:|...|||.:|  |||...| .:..||.:.:...|||:.|  |...:..::.|..:||:..|.
  Rat  2381 VTLAADRGGADVASIHLLITRP-TRLQLFRKALLMGGSALSPAAIISPDRAQQQAAALAKEVGCP 2444

  Fly   275 MVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNF 339
            ..:|:::.:|..:..|         :.|.::...:       ..:.||                |
  Rat  2445 NSSVQEVVSCFRQKPA---------NILNEAQTKL-------LAVSGP----------------F 2477

  Fly   340 SY--PAMGG-----CPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYID----------------H 381
            .|  |.:.|     .|.....|.|...||....|...|...|....:.                .
  Rat  2478 HYWGPVVDGQYLRELPSRRLKRPLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQ 2542

  Fly   382 VIRQTVG---TDKTMLLTSF-------VTHDF--FNRNLMENGTFDTLIPRLIDVAGTLNHKLPV 434
            .::.::|   :|..:|..:.       .|.|:  |:|.| ||.|.|..|            ..|:
  Rat  2543 ALQNSLGGEDSDARILAAAIWYYSLEHSTDDYASFSRAL-ENATRDYFI------------ICPI 2594

  Fly   435 LLALNMNNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFP---YPEHV 496
            :...::..:....|.|:|...                 :|.....:.|..:..|.|.   |..:.
  Rat  2595 VNMASLWARRTRGNVFMYHVP-----------------ESYGHGSLELLADVQYAFGLPFYSAYQ 2642

  Fly   497 TRLSRPDQSMAHRMVELWTNFVISGNPLGSARVGY--------------WPPMTTLYGPYMRIDD 547
            ...|..:||::.::::.::||:.||||      .|              ||            |.
  Rat  2643 GYFSMEEQSLSLKVMQYFSNFIRSGNP------NYPHEFSQKAAEFATPWP------------DF 2689

  Fly   548 TMTIGGNYFTEFSATLSDEE 567
            ....||..:.|.||.|.:.:
  Rat  2690 VPGAGGESYKELSAQLPNRQ 2709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	146/594 (25%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		150/605 (25%)
		COesterase	2198..2719	CDD:278561	150/605 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930