DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	582	Identity:	147/582 - (25%)
Similarity:	238/582 - (40%)	Gaps:	129/582 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLVLQSVVES----------RVRGRQYDEEKDTIVELPT--LGSIQGKILETAWTKREVLQFVD 63
            |.|||::..::          ::||.:        |.||:  ||.:.              |::.
Mouse    26 LSLVLRASTQAPAPTVNTHFGKLRGAR--------VPLPSEILGPVD--------------QYLG 68

  Fly    64 VRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSMDSLRRLDDV---------LDV--- 116
            |.||.||.|..||..|.|...|..:.:||.....||..:.    ..:.:|         ||:
Mouse    69 VPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIH----TAVPEVMLPVWFTANLDIVAT 129

  Fly   117 ------EDCLTMTITTPNV-------------------------TSRLPVLVYIHGEYLYEGSNS 150
                  ||||.:.:..|..                         :...||:|||||....||:.:
Mouse   130 YIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGN 194

  Fly   151 EAPPDYLLE-KDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPSRV 214
            ......|.. .:|:::|..||:|..|||||......||.|.||...||::|...|.:|||||.|:
Mouse   195 MIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRI 259

  Fly   215 TVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVTVR 279
            ||.|...||:...|||||. ...|||.:.|..||||:....:...|.|:...:|.|..|.::...
Mouse   260 TVFGSGIGASCVSLLTLSH-HSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTV 323

  Fly   280 DLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIG-GP---SGVLPKHPYDLMLETNF- 339
            |:..||.:.:|.||:...::.|              ::.:. ||   ..|:|..|..||.:..|
Mouse   324 DMVDCLRQKSAKELVEQDIQPA--------------RYHVAFGPVIDGDVIPDDPEILMEQGEFL 374

  Fly   340 SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFF 404
            :|..|.|..:..|.:.:..:||.:......|.:|:..|::|::.....|.|.......|:..|:.
Mouse   375 NYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWA 439

  Fly   405 NRNLMENGTFDTLIPRLIDVAGTLNHKL--PVLLALNMNNKHNPDNTFLYSFDYAGEFNRYKEMD 467
            :|:..|... .||:....|      |:.  |.::..:::.::. ..|:.|:|.:..:
Mouse   440 DRDNPETRR-KTLVALFTD------HQWVEPSVVTADLHARYG-SPTYFYAFYHHCQ-------- 488

  Fly   468 EETNLQSPFKAGVSLTDEALYLFPYPE------HVTRLSRPDQSMAHRMVELWTNFVISGNP 523
               :|..|..:..:..||..|:|..|.      .....|:.|..::..::..||||..:|:|
Mouse   489 ---SLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	141/552 (26%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	143/569 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832444
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740