DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and Cel

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	155/573 - (27%)
Similarity:	223/573 - (38%)	Gaps:	132/573 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LGSI--QGKILETAWTKREVL--QFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSV 101
            ||::  :|..:|....|..:|  ..||:....|.......:.|:....|:..:.||..|..|
  Rat    23 LGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKRC--- 84

  Fly   102 VSMDSLRRLDDVLDVEDCLTMTITTP----NVTSRLPVLVYIHG---------------EYLYEG 147
              :.:....||....||||.:.|..|    .|:..|||:|:|:|               .|||:|
  Rat    85 --LQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDG 147

  Fly   148 SNSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGGDPS 212
            .      :.....:|::||..||:||.|||||....:|||.|..|..:|:.:||..|..|||||.
  Rat   148 E------EIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPD 206

  Fly   213 RVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCKMVT 277
            .:|:.|:..|||...|.|||| ..:||..:.|..||.|:.|..::|:|...|:.||||..|....
  Rat   207 NITIFGESAGAASVSLQTLSP-YNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTED 270

  Fly   278 VRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETNFSYP 342
            ...:..|| ::|....||......|:..:..|.|                             |.
  Rat   271 TAKMAGCL-KITDPRALTLAYRLPLKSQEYPIVH-----------------------------YL 305

  Fly   343 AMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTY------------NYIDHVIRQTVGTDKTMLL 395
            |.  .|          :||.||   ||||..|.|            |.:|..:..||........
  Rat   306 AF--IP----------VVDGDF---IPDDPINLYDNAADIDYLAGINDMDGHLFATVDVPAIDKA 355

  Fly   396 TSFVTHDFFNR----NLMENG------TFDTLIPRLIDVAGTLNHK-------------LPVLLA 437
            ...||.:.|.|    :.:..|      |||.............|.|             :|..:|
  Rat   356 KQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMA 420

  Fly   438 LNMNNKH-NPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLS- 500
            |..:..| ....|:.|.|.:......|           |...|....|:..|:|..| ..|.|.
  Rat   421 LAQHRAHAKSAKTYSYLFSHPSRMPIY-----------PKWMGADHADDLQYVFGKP-FATPLGY 473

  Fly   501 -RPDQSMAHRMVELWTNFVISGNP-LGSARV-GYWPPMTTLYGPYMRIDDTMT 550
             ..|::::..|:..||||..||:| :|::.| .:|.|.||..|.|:.|:..:|
  Rat   474 RAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYTTENGNYLDINKKIT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	155/573 (27%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	153/570 (27%)
		Aes	<118..>247	CDD:223730	52/135 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740