Protein Alignment CG9287 and CES3

DIOPT Version :9

• Sequence 1: NP_609244.1
• Gene: CG9287 / 34194
• FlyBaseID: FBgn0032057
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 170/589 - (28%)
• Similarity: 261/589 - (44%)
• Gaps: 91/589 - (15%)

  Fly    31 EKDTIVELPTLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDA-TAE 94
            |.||     |||.::|:.:....|.|.|..|:.:.:|:||.|..||.||.|.:|||.|.|| ||.
Human    35 EVDT-----TLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAP 94

  Fly    95 KIGCPSVVSMDSLRRL----DDVLDV-EDCLTMTITTP---NVTSRLPVLVYIHGEYL------- 144
            .:....|.||:|.|.:    ..:..| ||||.:.:.:|   ...|..||:|::||..|
Human    95 PMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATS 159

  Fly   145 YEGSNSEAPPDYLLEKDVVLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKYFGG 209
            |:||...|      ..|||:||.|||||..||.||..:..|||.||||:..||::|:..|..|||
Human   160 YDGSALAA------YGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGG 218

  Fly   210 DPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHSGSAIMPIFLEEDPRKHAQEIAKKADCK 274
            |.:.|||.|...|.:|...|.||||. .||||:.|..||....|..::..|...||:||....|.
Human   219 DLNCVTVFGGSAGGSIISGLVLSPVA-AGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACS 282

  Fly   275 MVTVRDLNTCLMELTALEL-LTAFMEHALEKSDLGIGHTGGIQFTIGGPSGVLPKHPYDLMLETN 338
            ..:..::..||.:....|| |:..:::.:            ...|:.|.  |.||.|.:|:.|..
Human   283 SSSPAEMVQCLQQKEGEELVLSKKLKNTI------------YPLTVDGT--VFPKSPKELLKEKP 333

  Fly   339 F-SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSF---- 398
            | |.|.:.|            :.:::|...||.. :...:.::.:.|:.:....|.:|||.
Human   334 FHSVPFLMG------------VNNHEFSWLIPRG-WGLLDTMEQMSREDMLAISTPVLTSLDVPP 385

  Fly   399 -VTHDFFNRNLMENGTFDTLIPRLIDVAGTLNHKLP-VLLALNMNNKHNPDNTFLYSFDY-AGEF 460
             :.....:..|..|...........:..|.:...:| |..:..:.:..:|  .|.|.|.: ...|
Human   386 EMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSP--VFFYEFQHRPSSF 448

  Fly   461 NRYKE--MDEETNLQSPFK-AGVSLTDEALYLFPYPEHVTRLSRPDQSMAHRMVELWTNFVISGN 522
            .:.|.  :..:...:..|. .|..|.||:..| .:||    .:..::.::..|:..||:|..:|:
Human   449 AKIKPAWVKADHGAEGAFVFGGPFLMDESSRL-AFPE----ATEEEKQLSLTMMAQWTHFARTGD 508

  Fly   523 PLGSARVGYWPPMTTLYGPYMRIDDTMTIGGNYFTE-----FSATL-SDEEQGHSLIREVYYLRS 581
            | .|..:..||..... ..|:.| :.:...|..|.|     :|.|| |..:|.|.        :.
Human   509 P-NSKALPPWPQFNQA-EQYLEI-NPVPRAGQKFREAWMQFWSETLPSKIQQWHQ--------KQ 562

  Fly   582 RSRK 585
            ::||
Human   563 KNRK 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	161/554 (29%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	162/560 (29%)
		Aes	<129..>247	CDD:223730	52/124 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740