DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and Tg

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_006520808.2	Gene:	Tg / 21819	MGIID:	98733	Length:	2767	Species:	Mus musculus

Alignment Length:	616	Identity:	155/616 - (25%)
Similarity:	242/616 - (39%)	Gaps:	174/616 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QYDEEKDTIVELPTLGSIQG--KILE--TAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWED 87
            |.|......|.:.:.|.:||  ::::  |||  ::|.:|:.|.||.||...:||:||..:. |..
Mouse  2191 QSDVTSTPSVRIDSFGQLQGGSQVIKVGTAW--KQVYRFLGVPYAAPPLADNRFRAPEVLN-WTG 2252

  Fly    88 VMDATAEKIGC-------PSVVSMDSLRRLDDVLDVEDCLTMTITTP-NVTSRLPVLVYIHGEYL 144
            ..|||..:..|       |:...::           ||||.:.:..| |:.|...|||:.|....
Mouse  2253 SWDATKPRASCWQPGTRTPTPPQIN-----------EDCLYLNVFVPENLVSNASVLVFFHNTME 2306

  Fly   145 YEGSNSEAPPDYLLEKDV---VLVTPQYRLGPFGFLSTKTDEIPGNAGFLDIFLALQFVKHFIKY 206
            .|||..:...|..:...|   ::||..||||.|||||:.:||:.||.|.||...||.:|:..|..
Mouse  2307 MEGSGGQLTIDGSILAAVGNFIVVTANYRLGVFGFLSSGSDEVAGNWGLLDQVAALTWVQSHIGA 2371

  Fly   207 FGGDPSRVTVAGQVGGAAIA--HLLTLSPVVQRGLFHQVIYHSGSAIMP--IFLEEDPRKHAQEI 267
            |||||.|||:|....||.:|  |||...| .:..||.:.:...|||:.|  |...|..::.|..:
Mouse  2372 FGGDPQRVTLAADRSGADVASIHLLISRP-TRLQLFRKALLMGGSALSPAAIISPERAQQQAAAL 2435

  Fly   268 AKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHTGG------------------ 314
            ||:..|...:::::.:||.:..| .:|.......|..|  |..|..|
Mouse  2436 AKEVGCPTSSIQEVVSCLRQKPA-NILNDAQTKLLAVS--GPFHYWGPVVDGQYLRELPSRRLKR 2497

  Fly   315 -----IQFTIGG--PSGVLPKHPYDLMLE-----TNFS---YPA----MGGCPKNAGSRVLNEIV 360
                 :...|||  ..|::.:.......|     ||..   |.|    :||  :::.:|:|...|
Mouse  2498 PLPVKVDLLIGGSQDDGLINRAKAVKQFEESQGRTNSKTAFYQALQNSLGG--EDSDARILAAAV 2560

  Fly   361 DNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFVTHDF--FNRNLMENGTFDTLIPRLID 423
                          .|..::|                 .|.|:  |:|.| ||.|.|..|
Mouse  2561 --------------WYYSLEH-----------------STDDYASFSRAL-ENATRDYFI----- 2588

  Fly   424 VAGTLNHKLPVLLALNMNNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALY 488
                   ..|::...::..:....|.|:|...                 :|.....:.|..:..|
Mouse  2589 -------ICPMVNMASLWARRTRGNVFMYHVP-----------------ESYGHGSLELLADVQY 2629

  Fly   489 LFP---YPEHVTRLSRPDQSMAHRMVELWTNFVISGNPLGSARVGY--------------WPPMT 536
            .|.   |..:..:.|..:||::.::::.::||:.||||      .|              ||
Mouse  2630 AFGLPFYSAYQGQFSTEEQSLSLKVMQYFSNFIRSGNP------NYPHEFSRKAAEFATPWP--- 2685

  Fly   537 TLYGPYMRIDDTMTIGGNYFTEFSATLSDEE 567
                     |.....||..:.|.||.|.:.:
Mouse  2686 ---------DFIPGAGGESYKELSAQLPNRQ 2707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	149/601 (25%)
Tg	XP_006520808.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	301..359	CDD:238114
		TY	<612..658	CDD:238114
		TY	661..726	CDD:238114
		TY	730..>776	CDD:381826
		TY	<893..922	CDD:381826
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Ephrin_rec_like	1464..1509	CDD:311571
		TY	1519..1566	CDD:214561
		COesterase	2198..2717	CDD:365897	153/609 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832910
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7868
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.880