DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9287 and Nlgn2

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	738	Identity:	167/738 - (22%)
Similarity:	266/738 - (36%)	Gaps:	211/738 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LPTLGSIQGKILETAW-----TKRE--------VLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVM 89
            |.:||..:..::.||:     .:||        |:||:.|.||.||.|..||:.|.....|..|.
Mouse    33 LGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVR 97

  Fly    90 DATAEKIGCPS------------VVSMDSLRRLDDVL--DVEDCLTMTITTPNV----------- 129
            :||.....||.            |...|:|......:  ..||||.:.:..|..
Mouse    98 NATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEA 162

  Fly   130 -----------TSRLPVLVYIHGEYLYEGSNSEAPPDYLLE-KDVVLVTPQYRLGPFGFLSTKTD 182
                       :.:.||::::||....||:.:......|.. .:|::||..||||..|||||...
Mouse   163 TLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGDQ 227

  Fly   183 EIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHS 247
            ...||.|.||...||:::...|.:|||||.|:|:.|...||:..:||.||. ...|||.:.|..|
Mouse   228 AAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSH-HSEGLFQKAIAQS 291

  Fly   248 GSAIMPIFLEEDPRKHAQEIAKKADCKMVTVRDLNTCLMELTALELLTAFMEHALEKSDLGIGHT 312
            |:||....:...|.|:.:.:|.|..|......:...||...::.||:...::.|
Mouse   292 GTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAVECLRRKSSRELVDQDVQPA----------- 345

  Fly   313 GGIQFTIG-GP---SGVLPKHPYDLMLETNF-SYPAMGGCPKNAGSRVLNEIVDNDFEGKIPDDE 372
               ::.|. ||   ..|:|..|..||.:..| :|..:.|..:..|.:.:.:..:::........:
Mouse   346 ---RYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFD 407

  Fly   373 YNTYNYIDHVIRQTVGTDKTMLLTSFVTHDFFNRNLMENGTF--DTLIPRLIDVAGTLNHK--LP 433
            :...|::|::.....|.|.......|:..|:.:|   :||..  .||:....|      |:  .|
Mouse   408 FTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADR---DNGEMRRKTLLALFTD------HQWVAP 463

  Fly   434 VLLALNMNNKHNPDNTFLYSFDYAGEFNRYKEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTR 498
            .:....::..:.....|...:.:.....|.:..|.....:.|:..||.:.. |..|||     ..
Mouse   464 AVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVG-ATDLFP-----CN 522

  Fly   499 LSRPDQSMAHRMVELWTNFVISGNP-----------------------------------LG--- 525
            .|:.|..::..::..||||..:|:|                                   :|
Mouse   523 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKP 587

  Fly   526 -------SARVGYW---------------------PPMTTLYGPYMRIDDTMTIG---------- 552
                   :.:|.:|                     ||..|.:.|  |.....|.|
Mouse   588 RVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPP--RTPGPGTSGTRRPPPPATL 650

  Fly   553 --------------------GNYFTEFSATLSDEEQGHSLI-------REVYYLRSRSRKRALNK 590
                                .:|.||.|.|::   .|.||:       ..:||.|.
Mouse   651 PPESDIDLGPRAYDRFPGDSRDYSTELSVTVA---VGASLLFLNILAFAALYYKRD--------- 703

  Fly   591 RRKQLAKSNARRLQNPKLGGRKS 613
            ||::|   ..|||..|  ||..|
Mouse   704 RRQEL---RCRRLSPP--GGSGS 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	147/674 (22%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	135/588 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661		7/39 (18%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735		7/13 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740