DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9287 and cest-3

DIOPT Version :9

Sequence 1:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_510042.2	Gene:	cest-3 / 181385	WormBaseID:	WBGene00008451	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	129/576 - (22%)
Similarity:	214/576 - (37%)	Gaps:	146/576 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TLGSIQGKILETAWTKREVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSM 104
            |.|.::||.:..     :...|.:|.:|:||.|..||..|....||:::.:||...   ||..|.
Worm    27 TYGKLEGKTVNV-----DQHMFKNVPFAKPPLGKLRFSLPEWTNPWKNIRNATEYS---PSCFSN 83

  Fly   105 DSLRRLDDVLDV-EDCLTMTITTPNV---TSRLPVLVYIHGEYLYEGSNSEAPPDYLLEK----D 161
            .|:|...:...: ||||.:.:.|...   :.....:||.||..:...|..:....::||:    :
Worm    84 SSMRTDSNFFPMSEDCLYLNVFTNEYCLKSKNCSTVVYYHGGGINMDSAVQFNDTFILERYVKEN 148

  Fly   162 VVLVTPQYRLGPFGFLSTKTDE-IPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAI 225
            ||.:.|.||||.||.|...::. :|.|....|..|||:|:...|..|||....:.:.|...||.|
Worm   149 VVFIIPAYRLGIFGLLYFGSNNLVPQNLAIHDCELALRFIHQEISNFGGHKDDINLMGHSAGAHI 213

  Fly   226 AHLLTLSPVV--QRGLFHQVIYHSGSAIMPIFLEEDPR---KHAQEIAKKADC--KMVTVRD--L 281
            :.:...|..:  ...|.:::|     .:.|:...:.|.   |:..:.|::..|  :.||.||  :
Worm   214 SLIFGFSRHIDPDHKLINRII-----VLSPVPSYDMPELLIKNCYDFAERVGCYKRNVTARDTEI 273

  Fly   282 NTCLMELTALELLTA-----------------------------FMEHALEKSDLGIGHT-GGIQ 316
            ..||.:..|..|::.                             |.|:|: |.|:.||:| ..::
Worm   274 VKCLRKKDARGLMSMQRLMENDRLYFWNFLAGEPFMYRDESIADFKEYAV-KRDMLIGNTVDEVK 337

  Fly   317 F--------TIGGPSGVLPKHPYDLMLETNF--------------------SYPAMGGCPKNAGS 353
            :        .|.| |.:..::||::..:.||                    |.........|||.
Worm   338 WKRLKKENPAIAG-SFMDWENPYEVAHKFNFYHDSAPVNSTYESFTQGIFVSTATYAEAQANAGG 401

  Fly   354 RVLNEIVDNDFEGKIPDDEYNTYNYIDHVIRQTVGTDKTMLLTSFV-THDFFNRNLMENGT---- 413
            .|.....:......:.|.:|            .|||.:....||.: ..|.|...::.|.|
Worm   402 TVYLFQSNQQPSSHVSDMQY------------FVGTHREDYHTSDMDIMDTFYSKMIVNFTKFGS 454

  Fly   414 ----FDTLIPRLIDVAGTLNHKLPVLLALNMNNK-----------HNPDNTFLYSFDYAGEFNRY 463
                ::.|:|      ..:|:     .||.:|.:           |..|..|.        |...
Worm   455 PSPVWEPLVP------SRMNY-----YALEVNTEKGIWPRMEEDFHESDVNFW--------FINM 500

  Fly   464 KEMDEETNLQSPFKAGVSLTDEALYLFPYPEHVTRLSRPDQSMAHRMVELWTNFVI 519
            ...|.|...|.....|.|||...:    :|..|...::.::|.:..:...|..|.|
Worm   501 TAFDREVTRQKKTSNGTSLTWSPM----HPGPVILPTKTNESSSFDISSQWWFFAI 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	129/576 (22%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	114/506 (23%)
cest-3	NP_510042.2	Aes	<118..>254	CDD:223730	38/140 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740